Influence of Serotonin Transporter Gene Polymorphisms and Adverse Life Events on Depressive Symptoms in the Elderly: A Population-Based Study.

PubWeight™: 1.38‹?› | Rank: Top 10%

🔗 View Article (PMC 4658113)

Published in PLoS One on November 23, 2015

Authors

Annalisa Davin1, Maria Cristina Monti2, Letizia Polito1, Roberta Vaccaro1,3, Simona Abbondanza1, Marco Gnesi2, Simona Villani2, Antonio Guaita1

Author Affiliations

1: "Golgi Cenci" Foundation, Abbiategrasso, Italy.
2: Section of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
3: "C. Golgi" Geriatric Institute, Abbiategrasso, Italy.

Associated clinical trials:

A Longitudinal Multidimensional Population Study on Brain Aging (InveCeAb) | NCT01345110

Articles cited by this

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA (2009) 12.35

Allelic variation of human serotonin transporter gene expression. J Neurochem (1996) 7.08

A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34

Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27

Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry (2010) 6.15

The effects of stressful life events on depression. Annu Rev Psychol (1997) 5.98

A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry (2005) 4.33

Short versions of the geriatric depression scale: a study of their validity for the diagnosis of a major depressive episode according to ICD-10 and DSM-IV. Int J Geriatr Psychiatry (1999) 3.82

Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry (2006) 3.73

Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry (2004) 3.54

Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry (2006) 3.44

Stressful life events, genetic liability, and onset of an episode of major depression in women. Am J Psychiatry (1995) 3.22

Depression in older adults. Annu Rev Clin Psychol (2009) 3.07

Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand (2006) 2.99

A systematic review of prevalence studies of depression in Parkinson's disease. Mov Disord (2008) 2.81

Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry (2005) 2.35

Age- and gender-specific prevalence of depression in latest-life--systematic review and meta-analysis. J Affect Disord (2010) 2.20

Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol Psychiatry (2007) 2.11

Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Mol Psychiatry (2005) 2.06

Depression and frailty in later life: a synthetic review. Int J Geriatr Psychiatry (2011) 1.98

Cost of depression in Europe. J Ment Health Policy Econ (2006) 1.96

Origins of depression in later life. Psychol Med (2005) 1.84

Validation of a measure of physical illness burden at autopsy: the Cumulative Illness Rating Scale. J Am Geriatr Soc (1993) 1.83

Accuracy of the 15-item geriatric depression scale (GDS-15) in a community sample of the oldest old. Int J Geriatr Psychiatry (2003) 1.74

Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress Anxiety (2005) 1.64

The criterion validity of the Geriatric Depression Scale: a systematic review. Acta Psychiatr Scand (2006) 1.61

Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet (2004) 1.57

Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension. J Child Psychol Psychiatry (2013) 1.53

Social influences on health: is serotonin a critical mediator? Psychosom Med (2010) 1.33

Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain, and behavior. Cogn Affect Behav Neurosci (2006) 1.21

Age differences and similarities in the correlates of depressive symptoms. Psychol Aging (2002) 1.21

Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet (1998) 1.20

The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review. Drug Alcohol Depend (2010) 1.19

Combined effect of vision and hearing impairment on depression in older adults: evidence from the English Longitudinal Study of Ageing. J Affect Disord (2007) 1.16

Incidence and recurrence of late-life depression. Arch Gen Psychiatry (2008) 1.16

Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Mol Psychiatry (2005) 1.15

Age differences in stress, coping, and appraisal: findings from the Normative Aging Study. J Gerontol B Psychol Sci Soc Sci (1996) 1.14

The current state of play on the molecular genetics of depression. Psychol Med (2012) 1.03

Vascular disease and future risk of depressive symptomatology in older adults: findings from the Health, Aging, and Body Composition study. Biol Psychiatry (2008) 1.01

5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population. Neurobiol Aging (2008) 1.00

Depression in Alzheimer's disease: phenomenology, clinical correlates and treatment. Int Rev Psychiatry (2008) 0.95

Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet (1998) 0.94

Social relations and depression in late life-a systematic review. Int J Geriatr Psychiatry (2013) 0.93

Age and sex differences in prevalence and clinical correlates of depression: first results from the Irish Longitudinal Study on Ageing. Int J Geriatr Psychiatry (2013) 0.93

Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. Eur J Hum Genet (2004) 0.93

From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment. Can J Psychiatry (2014) 0.93

Marital status and risk for late life depression: a meta-analysis of the published literature. J Int Med Res (2011) 0.92

Stressful life events interacting with cognitive/personality styles to predict late-onset major depression. Am J Geriatr Psychiatry (2002) 0.91

Coping and depression in old age: a literature review. Dement Geriatr Cogn Disord (2013) 0.90

Adverse life events in elderly patients with major depression or dysthymic disorder and in healthy-control subjects. Am J Geriatr Psychiatry (2002) 0.88

Brief interventions to prevent depression in older subjects: a systematic review of feasibility and effectiveness. Am J Geriatr Psychiatry (2008) 0.88

Mental health and physical health of family caregivers for persons with dementia: a comparison of African American and white caregivers. Aging Ment Health (2007) 0.86

The effect of gender, age, and symptom severity in late-life depression on the risk of all-cause mortality: the Bambuí Cohort Study of Aging. Depress Anxiety (2013) 0.85

Brain aging and dementia during the transition from late adulthood to old age: design and methodology of the "Invece.Ab" population-based study. BMC Geriatr (2013) 0.83

Direct costs associated with depressive symptoms in late life: a 4.5-year prospective study. Int Psychogeriatr (2012) 0.82

Pharmacogenetics of antidepressant drugs: current clinical practice and future directions. Pharmacogenomics (2012) 0.81

Depression in subjects with and without dementia: a comparison using GMS-AGECAT. Int J Geriatr Psychiatry (2002) 0.80

Modulation of amygdala response and connectivity in depression by serotonin transporter polymorphism and diagnosis. J Affect Disord (2013) 0.80

Effects of depression on the subsequent year's healthcare expenditures among older adults: two-year panel study. Psychiatr Q (2015) 0.80

The association between depression and emotional and social loneliness in older persons and the influence of social support, cognitive functioning and personality: A cross-sectional study. J Affect Disord (2015) 0.80

Neural signatures of the interaction between the 5-HTTLPR genotype and stressful life events in healthy women. Psychiatry Res (2014) 0.78

Sibling death and death fear in relation to depressive symptomatology in older adults. J Gerontol B Psychol Sci Soc Sci (2009) 0.77

Serotonin transporter polymorphism modifies the association between depressive symptoms and sleep onset latency complaint in elderly people: results from the 'InveCe.Ab' study. J Sleep Res (2014) 0.77

Anxious, irritable and hostile depression re-appraised. J Affect Disord (2015) 0.77

The heterogeneous course of depressive symptoms for the dementia caregiver. Int J Aging Hum Dev (2014) 0.76