Published in Cell on June 30, 1989
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell (1999) 9.05
Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Mol Biol Cell (1996) 4.58
Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae. J Cell Biol (1991) 4.54
Membrane protein sorting in the yeast secretory pathway: evidence that the vacuole may be the default compartment. J Cell Biol (1992) 4.20
Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast. J Cell Biol (1990) 4.19
Cell wall and secreted proteins of Candida albicans: identification, function, and expression. Microbiol Mol Biol Rev (1998) 4.14
Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum. Mol Biol Cell (1992) 3.81
Stress-induced transcriptional activation. Microbiol Rev (1995) 3.78
Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Biol (2000) 3.73
Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67
Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol (1999) 3.57
A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein. J Cell Biol (1989) 3.56
Heat shock proteins: molecular chaperones of protein biogenesis. Microbiol Rev (1993) 3.51
TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J (1998) 3.49
The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution. Mol Biol Cell (1992) 3.35
The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol Cell Biol (1993) 3.25
Characterization of the Saccharomyces Golgi complex through the cell cycle by immunoelectron microscopy. Mol Biol Cell (1992) 3.25
Brome mosaic virus helicase- and polymerase-like proteins colocalize on the endoplasmic reticulum at sites of viral RNA synthesis. J Virol (1996) 3.17
BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. J Cell Biol (1990) 3.04
Parallel secretory pathways to the cell surface in yeast. J Cell Biol (1995) 2.92
Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol Biol Cell (1997) 2.91
Protein secretion in Bacillus species. Microbiol Rev (1993) 2.74
The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. EMBO J (1995) 2.73
Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J (1996) 2.72
The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. J Cell Biol (2000) 2.71
A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome. J Cell Biol (1993) 2.65
Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein. J Cell Biol (1991) 2.63
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J Cell Biol (1993) 2.61
Golgi structure correlates with transitional endoplasmic reticulum organization in Pichia pastoris and Saccharomyces cerevisiae. J Cell Biol (1999) 2.60
The Sec13p complex and reconstitution of vesicle budding from the ER with purified cytosolic proteins. EMBO J (1993) 2.56
ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus. EMBO J (1990) 2.53
Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation. Mol Cell Biol (1992) 2.51
The tobacco luminal binding protein is encoded by a multigene family. Plant Cell (1991) 2.47
The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm. Mol Biol Cell (1995) 2.46
Characterization of an immunoglobulin binding protein homolog in the maize floury-2 endosperm mutant. Plant Cell (1991) 2.43
Pheromone-regulated genes required for yeast mating differentiation. J Cell Biol (1998) 2.40
Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery. Mol Cell Biol (1990) 2.36
A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast. Mol Biol Cell (1992) 2.33
Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center. J Cell Biol (1996) 2.32
Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p. J Cell Biol (1995) 2.30
The Golgi-localization of yeast Emp47p depends on its di-lysine motif but is not affected by the ret1-1 mutation in alpha-COP. J Cell Biol (1995) 2.26
Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae. EMBO J (1993) 2.26
MID1, a novel Saccharomyces cerevisiae gene encoding a plasma membrane protein, is required for Ca2+ influx and mating. Mol Cell Biol (1994) 2.25
Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein. EMBO J (1998) 2.23
Continued functioning of the secretory pathway is essential for ribosome synthesis. Mol Cell Biol (1994) 2.20
Separate domains of KAR1 mediate distinct functions in mitosis and nuclear fusion. J Cell Biol (1992) 2.19
Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.14
All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1997) 2.14
Brome mosaic virus polymerase-like protein 2a is directed to the endoplasmic reticulum by helicase-like viral protein 1a. J Virol (2000) 2.13
BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum. Proc Natl Acad Sci U S A (1995) 2.09
Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 2.08
Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast. EMBO J (1998) 2.06
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs. Nucleic Acids Res (1997) 2.05
Characteristics of endoplasmic reticulum-derived transport vesicles. J Cell Biol (1994) 2.05
Sec12p-dependent membrane binding of the small GTP-binding protein Sar1p promotes formation of transport vesicles from the ER. J Cell Biol (1991) 2.04
Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70. J Cell Biol (1993) 2.02
Evidence for a novel route of wheat storage proteins to vacuoles. J Cell Biol (1992) 2.01
The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth. Mol Cell Biol (1990) 1.96
Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p. J Cell Biol (1995) 1.95
Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum. Mol Biol Cell (1993) 1.94
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae. EMBO J (1996) 1.93
Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae. J Cell Biol (2003) 1.92
SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. J Cell Biol (1993) 1.91
Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I. Mol Cell Biol (1991) 1.89
Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations. Mol Biol Cell (1996) 1.88
A novel SNARE complex implicated in vesicle fusion with the endoplasmic reticulum. EMBO J (1997) 1.88
kem mutations affect nuclear fusion in Saccharomyces cerevisiae. Genetics (1990) 1.87
BiP/Kar2p serves as a molecular chaperone during carboxypeptidase Y folding in yeast. J Cell Biol (1995) 1.87
Brome mosaic virus RNA replication proteins 1a and 2a colocalize and 1a independently localizes on the yeast endoplasmic reticulum. J Virol (1999) 1.85
Pex19p, a farnesylated protein essential for peroxisome biogenesis. Mol Cell Biol (1998) 1.85
Overexpression of BiP in tobacco alleviates endoplasmic reticulum stress. Plant Cell (1999) 1.84
Self-regulation of 70-kilodalton heat shock proteins in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.82
Nuclear congression and membrane fusion: two distinct events in the yeast karyogamy pathway. J Cell Biol (1994) 1.81
Stress response of yeast. Biochem J (1993) 1.79
The lumenal domain of Sec63p stimulates the ATPase activity of BiP and mediates BiP recruitment to the translocon in Saccharomyces cerevisiae. J Cell Biol (1997) 1.76
Dolichol phosphate mannose synthase is required in vivo for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and N glycosylation of protein in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.74
Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately. J Cell Biol (1990) 1.74
Vma21p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex. Mol Biol Cell (1994) 1.73
Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Mol Biol Cell (2005) 1.72
A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors. EMBO J (1996) 1.70
The Saccharomyces cerevisiae SEC20 gene encodes a membrane glycoprotein which is sorted by the HDEL retrieval system. EMBO J (1992) 1.69
A homolog of voltage-gated Ca(2+) channels stimulated by depletion of secretory Ca(2+) in yeast. Mol Cell Biol (2000) 1.69
Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum. Mol Biol Cell (1993) 1.69
A human virus protein, poliovirus protein 2BC, induces membrane proliferation and blocks the exocytic pathway in the yeast Saccharomyces cerevisiae. EMBO J (1995) 1.69
Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter. EMBO J (2001) 1.68
Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product. J Cell Biol (1998) 1.64
A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s. J Cell Biol (1995) 1.63
Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae. J Cell Biol (1992) 1.60
Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces relocalization of binding protein (BiP) within the ER to form the BiP bodies. Mol Biol Cell (1994) 1.59
In vivo examination of membrane protein localization and degradation with green fluorescent protein. Proc Natl Acad Sci U S A (1996) 1.59
Yeast proteins associated with microtubules in vitro and in vivo. Mol Biol Cell (1992) 1.59
Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway. EMBO J (1993) 1.59
Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins. Mol Biol Cell (2003) 1.59
Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae. Genetics (1993) 1.57
The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase. Mol Cell Biol (1992) 1.56
LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum. EMBO J (2000) 1.55
Enhanced accumulation of BiP in transgenic plants confers tolerance to water stress. Plant Physiol (2001) 1.55
Deletion of yeast p24 genes activates the unfolded protein response. Mol Biol Cell (2001) 1.55
Identification of sequences in Brome mosaic virus replicase protein 1a that mediate association with endoplasmic reticulum membranes. J Virol (2001) 1.55
Heat shock and the sorting of luminal ER proteins. EMBO J (1989) 1.54
Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast. J Cell Biol (1990) 4.19
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases. Proc Natl Acad Sci U S A (1988) 4.04
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells. Trends Microbiol (2000) 3.93
Sec61p and BiP directly facilitate polypeptide translocation into the ER. Cell (1992) 3.66
Evidence for pore-forming ability by Legionella pneumophila. Mol Microbiol (1998) 2.74
Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway. Infect Immun (1998) 2.15
Pregnancy and childbirth outcomes among adolescent mothers: a World Health Organization multicountry study. BJOG (2014) 1.93
Obstetric transition: the pathway towards ending preventable maternal deaths. BJOG (2014) 1.43
Molecular, morphological, and cytological analysis of diverse Brachypodium distachyon inbred lines. Genome (2009) 1.28
Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER. Mol Biol Cell (1998) 1.25
Advanced maternal age and pregnancy outcomes: a multicountry assessment. BJOG (2014) 1.08
The risks of unilateral nephrectomy: status of kidney donors 10 to 20 years postoperatively. Mayo Clin Proc (1985) 1.03
Development of criteria for identifying neonatal near-miss cases: analysis of two WHO multicountry cross-sectional studies. BJOG (2014) 0.93
Indirect causes of severe adverse maternal outcomes: a secondary analysis of the WHO Multicountry Survey on Maternal and Newborn Health. BJOG (2014) 0.91
Education and severe maternal outcomes in developing countries: a multicountry cross-sectional survey. BJOG (2014) 0.87
Continuous ambulatory peritoneal dialysis. Three years' experience at the Mayo Clinic. Mayo Clin Proc (1983) 0.84
Cystic fibrosis carrier screening practices in an ethnically diverse region: experience of the Genetic Network of the Empire State, Puerto Rico, and the U.S. Virgin Islands. Genet Test (1999) 0.76
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