Published in Biomolecules on November 20, 2015
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Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target. EBioMedicine (2017) 0.75
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Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer. Clin Cancer Res (2005) 1.99
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A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration. EMBO J (2000) 1.79
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The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L. Biochem J (1987) 1.44
Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis. Oncogene (2002) 1.42
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ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy. Clin Cancer Res (2008) 1.33
Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. Cancer Res (2009) 1.32
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Cadherin switching in ovarian cancer progression. Int J Cancer (2003) 1.25
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Catalytically inactive human cathepsin D triggers fibroblast invasive growth. J Cell Biol (2005) 1.22
A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis. Mol Genet Metab (2006) 1.20
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A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells. Oncogene (2001) 1.19
Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity. Oncogene (2006) 1.13
Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L. J Biol Chem (2005) 1.12
Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis. Cancer Res (2008) 1.11
Cathepsin D is a potential serum marker for poor prognosis in glioma patients. Cancer Res (2005) 1.10
The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. Int J Oncol (2008) 1.10
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Advanced cytoreduction as surgical standard of care and hyperthermic intraperitoneal chemotherapy as promising treatment in epithelial ovarian cancer. Eur J Surg Oncol (2010) 1.07
Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1. Carcinogenesis (2011) 1.06
Procathepsin L degrades extracellular matrix proteins in the presence of glycosaminoglycans in vitro. Biochem Biophys Res Commun (1995) 1.05
Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy. Int J Exp Pathol (2004) 1.04
Surface activation of pro-cathepsin L. Biochem Biophys Res Commun (1992) 1.04
Cathepsin D in breast cancer: a tissue marker associated with metastasis. Eur J Cancer (1992) 1.04
Mechanism for selective secretion of a lysosomal protease by transformed mouse fibroblasts. J Biol Chem (1989) 1.03
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Molecular cloning and sequencing of cDNA for rat cathepsin L. FEBS Lett (1987) 0.98
Effect of human procathepsin D on proliferation of human cell lines. Cancer Lett (1994) 0.97
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer. Am J Pathol (2003) 0.97
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Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10). Acta Neuropathol (2008) 0.96
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Procathepsin-L, a proteinase that cleaves human C3 (the third component of complement), confers high tumorigenic and metastatic properties to human melanoma cells. Cancer Res (1998) 0.94
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Mitogenic function of human procathepsin D: the role of the propeptide. Biochem J (1994) 0.94
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Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation. Biochem J (2004) 0.93
Cathepsin L increases invasion and migration of B16 melanoma. Cancer Cell Int (2007) 0.93
Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells. Mol Carcinog (1992) 0.91
Modulation of the transport of a lysosomal enzyme by PDGF. J Cell Biol (1990) 0.91
Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis. J Exp Clin Cancer Res (2011) 0.91
Human breast milk contains procathepsin D--detection by specific antibodies. Biochem Mol Biol Int (1993) 0.91
Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density. Gynecol Oncol (2004) 0.91
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells. J Biol Chem (2000) 0.90
Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal. Oncogene (1994) 0.90
Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D. Cell Death Differ (2003) 0.90
Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects. Neuroscience (2010) 0.89
Regulation of tumor cell invasion by extracellular matrix. Histol Histopathol (1999) 0.89
Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor. J Biol Chem (1990) 0.87
Increased cathepsin L levels in serum in some patients with ovarian cancer: comparison with CA125 and CA72-4. Gynecol Oncol (1995) 0.87
Effect of procathepsin D and its activation peptide on prostate cancer cells. Cancer Lett (1998) 0.87
Molecular forms of beta-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes. Biochem J (1983) 0.87
Role of procathepsin D activation peptide in prostate cancer growth. Prostate (2000) 0.86