Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 26621850)

Published in Oncotarget on January 19, 2016

Authors

Huanrong Hu1,2, Zhen Dong2, Peng Tan2, Yanli Zhang1, Lichao Liu1, Liqun Yang2, Yaling Liu1, Hongjuan Cui2

Author Affiliations

1: Department of Dermatology, The Third Hospital of Hebei Medical University, Shijiazhuang, 050000, P.R. China.
2: State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400715, P.R. China.

Articles cited by this

Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med (2010) 67.34

Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med (2011) 45.46

Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol (2009) 23.08

Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin (2014) 11.09

p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer (2009) 9.21

Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol (2001) 6.43

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J (1999) 5.44

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell (2011) 2.68

Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease. Oncotarget (2015) 2.28

Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett (2002) 2.21

Tigecycline: a critical analysis. Clin Infect Dis (2006) 2.06

Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition. Mol Cell Biol (1998) 2.02

Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events. Cell Cycle (2007) 1.88

Incidence of sentinel node metastasis in patients with thin primary melanoma (< or = 1 mm) with vertical growth phase. Ann Surg Oncol (2000) 1.74

p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells. Oncogene (1997) 1.70

Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev (2004) 1.65

Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion. Breast Cancer Res (2013) 1.64

Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J Biol Chem (2003) 1.52

Doxycycline Induces Apoptosis and Inhibits Proliferation and Invasion of Human Cervical Carcinoma Stem Cells. PLoS One (2015) 1.44

Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis. Biochemistry (Mosc) (2012) 1.39

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy. Oncotarget (2015) 1.39

Are p27 and p21 cytoplasmic oncoproteins? Cell Cycle (2003) 1.33

Pathways and therapeutic targets in melanoma. Oncotarget (2014) 1.17

Tigecycline: a novel broad-spectrum antimicrobial. Ann Pharmacother (2007) 1.12

Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil. Oncotarget (2015) 1.11

Pharmacokinetic/pharmacodynamic profile for tigecycline-a new glycylcycline antimicrobial agent. Diagn Microbiol Infect Dis (2005) 1.10

High levels of expression of p27KIP1 and cyclin E in invasive primary malignant melanomas. J Invest Dermatol (1999) 1.00

Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells. Br J Pharmacol (2010) 0.98

Minocycline inhibits the growth of glioma by inducing autophagy. Autophagy (2011) 0.97

Life without kinase: cyclin E promotes DNA replication licensing and beyond. Mol Cell (2007) 0.90

In vitro activities of aminomethyl-substituted analogs of novel tetrahydrofuranyl carbapenems. Antimicrob Agents Chemother (1999) 0.89

Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: in vitro and in vivo studies. PLoS One (2013) 0.88

Cell cycle inhibitor p21/ WAF1/ CIP1 as a cofactor of MITF expression in melanoma cells. Pigment Cell Melanoma Res (2010) 0.87

Doxycycline as an inhibitor of the epithelial-to-mesenchymal transition and vasculogenic mimicry in hepatocellular carcinoma. Mol Cancer Ther (2014) 0.86

Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry. Oncotarget (2015) 0.85

Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death. Neuro Oncol (2013) 0.85

Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression. Oncotarget (2015) 0.83

Anti-programmed death receptor 1 immunotherapy in melanoma: rationale, evidence and clinical potential. Ther Adv Med Oncol (2015) 0.82

Immunohistochemical expression of p16, p21, p27 and cyclin D1 in oral nevi and melanoma. Head Neck Pathol (2012) 0.82

Antibiotic drug tigecycline inhibited cell proliferation and induced autophagy in gastric cancer cells. Biochem Biophys Res Commun (2014) 0.80

Minocycline attenuates hypoxia-inducible factor-1α expression correlated with modulation of p53 and AKT/mTOR/p70S6K/4E-BP1 pathway in ovarian cancer: in vitro and in vivo studies. Am J Cancer Res (2015) 0.78

p21{Waf1/CIP1} is a poor diagnostic and prognostic marker for OSCC although its expression increases in patients with N1 regional metastasis. Cancer Biomark (2015) 0.77

Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. Cancer Res (2015) 0.77