Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer.

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🔗 View Article (PMID 26689995)

Published in Oncotarget on January 19, 2016

Authors

Ijeoma Umelo1, Amir Noeparast1, Gang Chen1, Marleen Renard2, Caroline Geers3, Johan Vansteenkiste4, Philippe Giron1, Olivier De Wever5, Erik Teugels1, Jacques De Grève1

Author Affiliations

1: Laboratory of Molecular Oncology and Department of Medical Oncology, Oncologisch Centrum, UZ Brussel, Vrije Universiteit Brussels, Bruxelles, Belgium.
2: Pediatric Hemato-Oncology, UZ Leuven, Leuven, Belgium.
3: Department of Pathology, UZ Brussel, Bruxelles, Belgium.
4: Department of Pneumology, Universitair Ziekenhuis Leuven, Leuven, Belgium.
5: Laboratory of Experimental Cancer Research and Department of Radiotherapy, Universitair Ziekenhuis Gent, Gent, Belgium.

Associated clinical trials:

Study of Patritumab in Combination With Erlotinib in Subjects With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC). (HER3-Lung) (HER3-Lung) | NCT02134015

First-Line EGFR-1 Tyrosine Kinase Inhibition in Patients With NSCLC With Mutant EGFR Gene | NCT00339586

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