Published in Am J Respir Crit Care Med on May 15, 2016
Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One (2017) 1.39
Intravascular hemolysis and the pathophysiology of sickle cell disease. J Clin Invest (2017) 0.78
New insights into sickle cell disease: mechanisms and investigational therapies. Curr Opin Hematol (2016) 0.77
Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function. Br J Haematol (2016) 0.75
Compartmentalization Is Key in Limiting Nitric Oxide Scavenging by Cell-Free Hemoglobin. Am J Respir Crit Care Med (2016) 0.75
"Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels. Pflugers Arch (2017) 0.75
Corticosterone, inflammation, immune status and telomere length in frigatebird nestlings facing a severe herpesvirus infection. Conserv Physiol (2017) 0.75
A mechanistic investigation of thrombotic microangiopathy associated with intravenous abuse of Opana ER. Blood (2016) 0.75
Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension. Am J Physiol Heart Circ Physiol (2017) 0.75
Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med (2004) 10.51
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med (2002) 7.59
Identification of the haemoglobin scavenger receptor. Nature (2001) 7.05
The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA (2005) 6.49
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. J Am Chem Soc (2008) 5.52
Hemoglobin and the paracrine and endocrine functions of nitric oxide. N Engl J Med (2003) 4.98
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation (2011) 3.81
Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry (1996) 3.36
Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest (2005) 2.75
A central role for free heme in the pathogenesis of severe sepsis. Sci Transl Med (2010) 2.54
Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat Biotechnol (1998) 2.35
Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med (2006) 2.33
Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood (2012) 2.22
Genomic insights into the immune system of the sea urchin. Science (2006) 2.20
Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest (2012) 2.19
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood (2012) 2.10
No scavenging and the hypertensive effect of hemoglobin-based blood substitutes. Free Radic Biol Med (2004) 1.96
Haptoglobin: basic and clinical aspects. Antioxid Redox Signal (2010) 1.94
Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest (2009) 1.77
The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica (2012) 1.72
Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes. J Am Chem Soc (2012) 1.67
Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation (2008) 1.60
Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function. Am J Respir Crit Care Med (2015) 1.48
Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood (2009) 1.46
Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol (1985) (1993) 1.45
Structure of the haptoglobin-haemoglobin complex. Nature (2012) 1.40
Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias. Free Radic Biol Med (2006) 1.36
Cardiovascular abnormalities in sickle cell disease. J Am Coll Cardiol (2012) 1.31
Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. Blood (2015) 1.25
Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies. Cold Spring Harb Perspect Med (2013) 1.18
Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin. Nitric Oxide (2008) 1.14
Hemoglobin-based oxygen carriers: From mechanisms of toxicity and clearance to rational drug design. Trends Mol Med (2010) 1.09
Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145. Antioxid Redox Signal (2012) 1.08
Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin. J Proteome Res (2010) 1.07
Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology (2010) 1.05
Autologous transfusion of stored red blood cells increases pulmonary artery pressure. Am J Respir Crit Care Med (2014) 1.02
Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity. Antioxid Redox Signal (2013) 1.01
Haptoglobin, a hemoglobin-binding plasma protein, is present in bony fish and mammals but not in frog and chicken. Proc Natl Acad Sci U S A (2006) 0.98
Evolutionary aspects of hemoglobin scavengers. Antioxid Redox Signal (2010) 0.92
Diversity of animal immune receptors and the origins of recognition complexity in the deuterostomes. Dev Comp Immunol (2014) 0.88
Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med (2015) 0.87
Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications. Front Physiol (2014) 0.85
Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity. Free Radic Biol Med (2015) 0.85
Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage. Front Physiol (2014) 0.84
Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model. Toxicol Sci (2012) 0.81
Kinetic and spectroscopic characterization of an intermediate peroxynitrite complex in the nitrogen monoxide induced oxidation of oxyhemoglobin. FEBS Lett (1998) 0.78