Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury.

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Published in Mol Cell Proteomics on December 22, 2015

Authors

Erna A van Niekerk1, Mark H Tuszynski2, Paul Lu2, Jennifer N Dulin3

Author Affiliations

1: From the ‡Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093; errrna@gmail.com.
2: From the ‡Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093; §Veterans Administration Medical Center, San Diego, CA 92161.
3: From the ‡Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093;

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30

Global quantification of mammalian gene expression control. Nature (2011) 22.36

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Glial inhibition of CNS axon regeneration. Nat Rev Neurosci (2006) 6.91

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science (2008) 6.86

Quantitative mass spectrometry in proteomics: a critical review. Anal Bioanal Chem (2007) 6.80

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A (1998) 5.98

Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol (1999) 5.29

Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell (2012) 5.15

Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat Rev Neurosci (2003) 4.60

GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell (2005) 4.42

PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci (2010) 4.28

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp Neurol (2007) 4.00

Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science (1981) 3.94

KLF family members regulate intrinsic axon regeneration ability. Science (2009) 3.80

NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron (2004) 3.72

Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science (2002) 3.54

Axon regeneration requires a conserved MAP kinase pathway. Science (2009) 3.48

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science (2011) 3.45

Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators. Cell (2005) 3.42

P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature (2002) 3.27

SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron (2009) 3.22

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci (2002) 3.21

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18

Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci (2001) 3.11

Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron (2005) 3.09

Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol (2003) 3.09

Peripheral regeneration. Annu Rev Neurosci (2007) 2.94

Rho signaling pathway targeted to promote spinal cord repair. J Neurosci (2002) 2.90

Neuronal intrinsic mechanisms of axon regeneration. Annu Rev Neurosci (2011) 2.90

Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron (2012) 2.88

Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron (2010) 2.88

Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature (2003) 2.87

PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science (2009) 2.84

The role of extracellular matrix in CNS regeneration. Curr Opin Neurobiol (2007) 2.77

Axonal growth-associated proteins. Annu Rev Neurosci (1989) 2.76

Functional regeneration of sensory axons into the adult spinal cord. Nature (2000) 2.70

Adaptation in the chemotactic guidance of nerve growth cones. Nature (2002) 2.65

Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc Natl Acad Sci U S A (2001) 2.65

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature (1994) 2.57

A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. J Neurosci (1997) 2.52

Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J Neurosci (2007) 2.51

Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron (2002) 2.48

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci (2009) 2.42

Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration. J Neurosci (2005) 2.42

ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J Neurosci (2007) 2.40

Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal Chem (2004) 2.40

Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nat Biotechnol (2003) 2.37

A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat Neurosci (2002) 2.30

Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones. Neuron (2003) 2.30

The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol (2003) 2.28

Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol (1990) 2.19

MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron (2005) 2.15

Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell (2013) 2.09

Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci (1997) 2.07

Assembly of a new growth cone after axotomy: the precursor to axon regeneration. Nat Rev Neurosci (2012) 2.07

Peripheral injury enhances central regeneration of primary sensory neurones. Nature (1984) 2.05

Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Neuron (2008) 2.04

NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci (2002) 2.03

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci (2010) 2.02

Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci (2006) 1.99

Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo. Neuron (2004) 1.98

The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron (2000) 1.95

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury. Nature (2014) 1.95

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci (2012) 1.94

Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature (2002) 1.94

PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons. J Neurosci (2010) 1.91

A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration. J Neurosci (2009) 1.90

Localized sources of neurotrophins initiate axon collateral sprouting. J Neurosci (1998) 1.90

Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem (2009) 1.84

Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J Neurosci (1999) 1.82

Functional regeneration beyond the glial scar. Exp Neurol (2014) 1.79

BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol (2005) 1.75

Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci (2006) 1.73

BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration. J Neurosci (1997) 1.71

Mechanisms of acute axonal degeneration in the optic nerve in vivo. Proc Natl Acad Sci U S A (2010) 1.70

Intracellular control of developmental and regenerative axon growth. Philos Trans R Soc Lond B Biol Sci (2006) 1.70

The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. Mol Cell Neurosci (2003) 1.67

Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron (1999) 1.65

The transcription factor ATF-3 promotes neurite outgrowth. Mol Cell Neurosci (2006) 1.62

Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons. J Neurosci (2009) 1.61

Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system. J Neurosci (2008) 1.60

Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding. Nat Neurosci (2006) 1.59

In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration. Proc Natl Acad Sci U S A (2011) 1.59

Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS. J Neurosci (2008) 1.58

Signaling to transcription networks in the neuronal retrograde injury response. Sci Signal (2010) 1.57

Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons. Mol Cell Neurosci (2003) 1.55

Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition. J Neurosci (2003) 1.52

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Proc Natl Acad Sci U S A (2012) 1.52

Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci (2008) 1.49

Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Exp Neurol (2002) 1.48

Sumoylation in axons triggers retrograde transport of the RNA-binding protein La. Proc Natl Acad Sci U S A (2007) 1.45

Growth factors and combinatorial therapies for CNS regeneration. Exp Neurol (2007) 1.44

A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis. J Neurosci (2000) 1.43

AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells. Gene Ther (2006) 1.41

Spectrin and calpain: a 'target' and a 'sniper' in the pathology of neuronal cells. Cell Mol Life Sci (2005) 1.41

Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron (2000) 1.40

Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the rat. Exp Neurol (2001) 1.40

Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc Natl Acad Sci U S A (2009) 1.39

Neutron-encoded mass signatures for multiplexed proteome quantification. Nat Methods (2013) 1.39