Published in PLoS One on December 23, 2015
Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (2003) 100.88
A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med (2002) 58.15
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78
mTOR signaling in growth control and disease. Cell (2012) 29.21
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med (2011) 13.74
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci U S A (2005) 13.54
Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res (2005) 8.73
g:Profiler--a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res (2007) 6.44
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol (2004) 6.00
Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer (2009) 5.89
Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci (2006) 5.11
The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer (2012) 4.72
SuperPose: a simple server for sophisticated structural superposition. Nucleic Acids Res (2004) 4.09
g:Profiler--a web server for functional interpretation of gene lists (2011 update). Nucleic Acids Res (2011) 3.94
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J (2012) 3.82
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature (2001) 3.65
Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci (2010) 3.61
Knowledge-based prediction of protein structures and the design of novel molecules. Nature (1987) 2.99
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J (2010) 2.98
4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications. Cancer Res (2007) 2.67
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol (2009) 2.57
Functional diversity of the hnRNPs: past, present and perspectives. Biochem J (2010) 2.29
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol Cell Biol (1991) 2.00
Characterization of S6K2, a novel kinase homologous to S6K1. Oncogene (1999) 1.82
Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. J Biol Chem (1998) 1.74
Functions and regulation of the 70kDa ribosomal S6 kinases. Int J Biochem Cell Biol (2010) 1.70
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA (2008) 1.69
S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation. J Biol Chem (2008) 1.65
A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res (2011) 1.53
The dark side of E2F1: in transit beyond apoptosis. Cancer Res (2012) 1.52
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Proc Natl Acad Sci U S A (1998) 1.38
Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer. Breast Cancer Res Treat (2010) 1.27
Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer. Cancer Res (1999) 1.23
Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J Biol Chem (2009) 1.17
Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment. Endocr Relat Cancer (2011) 1.10
High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1. Genes Chromosomes Cancer (2011) 1.04
Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res (2010) 1.03
Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer. Breast Cancer Res (2012) 1.01
Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. Oncogene (2011) 0.97
The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials. Breast Cancer Res (2013) 0.97
Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway. J Biol Chem (2010) 0.92
S6K2: The Neglected S6 Kinase Family Member. Front Oncol (2013) 0.92
Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen. Pharmacogenomics J (2013) 0.91
E2F1 regulates cellular growth by mTORC1 signaling. PLoS One (2011) 0.91
Identification of S6K2 as a centrosome-located kinase. FEBS Lett (2007) 0.90
Phosphorylated S6K1 is a possible marker for endocrine therapy resistance in hormone receptor-positive breast cancer. Breast Cancer Res Treat (2010) 0.89
The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha. Nucleic Acids Res (2006) 0.89
Interaction between IGF-IR and ER induced by E2 and IGF-I. PLoS One (2013) 0.87
Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice. Cancer Biol Ther (2013) 0.86
S6 kinase 2 promotes breast cancer cell survival via Akt. Cancer Res (2011) 0.84
Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif. Biochem J (2013) 0.83
ERα, SKP2 and E2F-1 form a feed forward loop driving late ERα targets and G1 cell cycle progression. Oncogene (2013) 0.81