Published in Viruses on December 19, 2015
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HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic (2010) 2.47
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APOBEC-mediated editing of viral RNA. Science (2004) 2.15
Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse. Immunity (2006) 1.90
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. Nature (2015) 1.85
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. Nature (2015) 1.83
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Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc Natl Acad Sci U S A (2007) 1.56
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Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells. Cell Host Microbe (2009) 1.52
HIV-1 Nef interferes with host cell motility by deregulation of Cofilin. Cell Host Microbe (2009) 1.50
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes. J Virol (1995) 1.49
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The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR. J Virol (2012) 1.35
The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity. J Biol Chem (2006) 1.25
Vpu binds directly to tetherin and displaces it from nascent virions. PLoS Pathog (2013) 1.21
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Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovirology (2007) 1.08
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Nef enhances HIV-1 infectivity via association with the virus assembly complex. Virology (2008) 1.01
HIV-1 Nef: a multifaceted modulator of T cell receptor signaling. Cell Commun Signal (2012) 0.99
Human immunodeficiency virus type 1 Nef incorporation into virions does not increase infectivity. J Virol (2008) 0.97
HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo. Proc Natl Acad Sci U S A (2012) 0.95
HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling. Blood (2011) 0.95
Nef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles. J Virol (2008) 0.93
Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse. Eur J Cell Biol (2010) 0.93
HIV-1 Nef responsiveness is determined by Env variable regions involved in trimer association and correlates with neutralization sensitivity. Cell Rep (2013) 0.92
Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo. Retrovirology (2009) 0.91
The activity of Nef on HIV-1 infectivity. Front Microbiol (2014) 0.90
The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex. J Virol (2014) 0.90
Downregulation of cell surface CD4 by nef. Res Virol (1992) 0.88
Vpr overcomes macrophage-specific restriction of HIV-1 Env expression and virion production. Cell Host Microbe (2014) 0.84
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HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer. Retrovirology (2013) 0.78