Published in Exp Neurobiol on October 12, 2015
Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification. J Biol Chem (2016) 1.05
Oxidative stress, innate immunity, and age-related macular degeneration. AIMS Mol Sci (2016) 0.83
Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance. Acta Pharmacol Sin (2016) 0.79
NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener (2017) 0.78
The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review. Oxid Med Cell Longev (2016) 0.77
Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells. Int J Mol Sci (2016) 0.77
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway. Cell Mol Neurobiol (2016) 0.77
An isozyme-specific redox switch in human brain glycogen phosphorylase modulates its allosteric activation by AMP. J Biol Chem (2016) 0.76
Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly. J Huntingtons Dis (2016) 0.75
Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport. Mol Neurodegener (2017) 0.75
The Diverse Roles of Microglia in the Neurodegenerative Aspects of Central Nervous System (CNS) Autoimmunity. Int J Mol Sci (2017) 0.75
Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial. Front Aging Neurosci (2016) 0.75
Fucoxanthin prevents H2O2-induced neuronal apoptosis via concurrently activating the PI3-K/Akt cascade and inhibiting the ERK pathway. Food Nutr Res (2017) 0.75
Antioxidant and Membrane Binding Properties of Serotonin Protect Lipids from Oxidation. Biophys J (2017) 0.75
The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death. Mol Neurobiol (2016) 0.75
Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol (2017) 0.75
Protective effects of parecoxib on rat primary astrocytes from oxidative stress induced by hydrogen peroxide. J Zhejiang Univ Sci B (2016) 0.75
Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals. Biomed Res Int (2016) 0.75
Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics. PLoS Genet (2016) 0.75
Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms. Oxid Med Cell Longev (2016) 0.75
Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration. Hippocampus (2016) 0.75
The Influence of Fluorine on the Disturbances of Homeostasis in the Central Nervous System. Biol Trace Elem Res (2016) 0.75
Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo. Toxicol Appl Pharmacol (2016) 0.75
Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases. Oxid Med Cell Longev (2017) 0.75
Glutathione peroxidase 4: a new player in neurodegeneration? Mol Psychiatry (2016) 0.75
Cannabinoid CB2 receptors are involved in the protection of RAW264.7 macrophages against the oxidative stress: an in vitro study. Eur J Histochem (2017) 0.75
DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metab (2017) 0.75
Energy metabolism and whole-exome sequencing-based analysis of Sasang constitution: a pilot study. Integr Med Res (2017) 0.75
Distinct Mechanisms Underlying Resveratrol-Mediated Protection from Types of Cellular Stress in C6 Glioma Cells. Int J Mol Sci (2017) 0.75
The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases. J Cell Biol (2017) 0.75
Targeting urate to reduce oxidative stress in Parkinson disease. Exp Neurol (2017) 0.75
Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease. J Photochem Photobiol B (2017) 0.75
Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options. Front Plant Sci (2017) 0.75
TLDc proteins: new players in the oxidative stress response and neurological disease. Mamm Genome (2017) 0.75
Neuroprotective Activities of Spirulina platensis in the 6-OHDA Model of Parkinson's Disease Are Related to Its Anti-Inflammatory Effects. Neurochem Res (2017) 0.75
Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model. PLoS One (2017) 0.75
Sinomenine Protects PC12 Neuronal Cells against H2O2-induced Cytotoxicity and Oxidative Stress via a ROS-dependent Up-regulation of Endogenous Antioxidant System. Cell Mol Neurobiol (2017) 0.75
Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates. Sci Rep (2017) 0.75
Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications. Oxid Med Cell Longev (2017) 0.75
Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes. Exp Neurol (2017) 0.75
Tectorigenin attenuates the MPP(+)-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition. Exp Ther Med (2017) 0.75
Dietary Modulation of Oxidative Stress in Alzheimer's Disease. Int J Mol Sci (2017) 0.75
Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol (2006) 21.58
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
Free radicals in the physiological control of cell function. Physiol Rev (2002) 19.62
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature (2006) 15.69
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev (1999) 13.43
NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol (2004) 12.93
Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med (2005) 12.04
Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73
Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci (2003) 8.84
Pathways towards and away from Alzheimer's disease. Nature (2004) 8.72
Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed (2000) 8.18
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med (1997) 7.56
Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med (2000) 6.25
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron (2007) 6.07
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65
Oxidative stress and neurodegeneration: where are we now? J Neurochem (2006) 5.44
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal (2007) 5.17
Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol (2008) 5.03
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol (2002) 4.60
Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol (2008) 4.58
Architecture of succinate dehydrogenase and reactive oxygen species generation. Science (2003) 4.40
Metabolism and functions of glutathione in brain. Prog Neurobiol (2000) 3.74
NADPH oxidase. Curr Opin Immunol (2004) 3.58
Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med (1993) 3.40
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol (2002) 3.35
Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA (2002) 3.19
Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2006) 3.13
Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro. Proc Natl Acad Sci U S A (1991) 3.07
NADPH oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol (2009) 2.83
A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res (2000) 2.79
Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA (2014) 2.75
Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J Neurosci (2007) 2.69
Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med (2008) 2.68
Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol (1994) 2.65
Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol (2004) 2.62
NADPH oxidases of the brain: distribution, regulation, and function. Antioxid Redox Signal (2006) 2.56
Glutathione peroxidases. Biochim Biophys Acta (2012) 2.53
Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Oncogene (2006) 2.46
Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J Neurochem (1989) 2.44
Expression and localization of NOX2 and NOX4 in primary human endothelial cells. Antioxid Redox Signal (2005) 2.32
Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol (1996) 2.22
Reactive oxygen species in mitochondria-mediated cell death. Drug Metab Rev (2007) 2.20
Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol (2005) 2.20
Peroxisomes and oxidative stress. Biochim Biophys Acta (2006) 2.17
Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci (2012) 2.15
Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med (1997) 2.14
Structure and function of xanthine oxidoreductase: where are we now? Free Radic Biol Med (2002) 2.06
Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. J Biol Chem (2000) 2.04
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med (2011) 2.03
Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem (2000) 2.03
Glutathione pathways in the brain. Biol Chem (2003) 2.01
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.00
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev (2014) 1.96
Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci (2010) 1.96
Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med (2008) 1.83
Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins. Antioxid Redox Signal (2011) 1.79
A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol (2014) 1.78
Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev (2012) 1.76
Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging (2003) 1.75
Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology (2002) 1.75
The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Cardiovasc Res (2005) 1.72
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem (2005) 1.64
Hydrogen peroxide as a cell-survival signaling molecule. Antioxid Redox Signal (2009) 1.63
Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. Free Radic Biol Med (2001) 1.60
Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology (1995) 1.58
Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol (2014) 1.54
Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra. Magn Reson Med (2003) 1.49
Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study. Neurology (2015) 1.47
Oxidative stress and the pathogenesis of Alzheimer's disease. Oxid Med Cell Longev (2013) 1.44
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox Biol (2013) 1.44
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism. Neurobiol Dis (2012) 1.39
Individual dopaminergic neurons show raised iron levels in Parkinson disease. Neurology (2007) 1.38
Role of mitochondrial dysfunction in Alzheimer's disease. J Neurosci Res (2002) 1.37
An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases. Int J Mol Sci (2012) 1.37
Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows. Ann N Y Acad Sci (2008) 1.32
Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol (2012) 1.32
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta (2013) 1.29
Reactive oxygen species: stuck in the middle of neurodegeneration. J Alzheimers Dis (2010) 1.28
Regulation of endothelial function by mitochondrial reactive oxygen species. Antioxid Redox Signal (2011) 1.25
The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species. J Bioenerg Biomembr (2000) 1.25
Redox signaling loops in the unfolded protein response. Cell Signal (2012) 1.24
Antioxidant therapy: current status and future prospects. Curr Med Chem (2011) 1.23
Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alzheimer Dis Assoc Disord (1998) 1.22
The reaction of superoxide with reduced glutathione. Arch Biochem Biophys (1994) 1.21
Mitochondrial dysfunction, oxidative stress and neurodegeneration. J Alzheimers Dis (2006) 1.20
SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. J Biol Chem (2011) 1.19
Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J (2010) 1.18
Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease. Neurology (2001) 1.17
Antioxidant responses and cellular adjustments to oxidative stress. Redox Biol (2015) 1.15
Apoptosis and oxidative stress in neurodegenerative diseases. J Alzheimers Dis (2014) 1.15
Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis. Free Radic Biol Med (2012) 1.13
NADPH oxidase-derived reactive oxygen species: involvement in vascular physiology and pathology. Cell Tissue Res (2010) 1.11
Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease. Neurology (1998) 1.09
Oxidative stress and Parkinson's disease. Front Neuroanat (2015) 1.08
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease. Neuroscience (2001) 1.08
Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radic Biol Med (2012) 1.07
Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells. Ann Nucl Med (2001) 1.06
Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Acta Neuropathol (2008) 1.05
Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation. Antioxid Redox Signal (2010) 1.05
Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology. Clin Exp Pharmacol Physiol (2003) 1.04
Peripheral Biomarker Candidates of Posttraumatic Stress Disorder. Exp Neurobiol (2015) 0.75