Published in Trends Biochem Sci on January 01, 2003
Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76
Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04
DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep (2004) 3.84
Circadian clocks in human red blood cells. Nature (2011) 3.39
Reactive oxygen species in cancer. Free Radic Res (2010) 3.20
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A (2007) 2.87
Signaling functions of reactive oxygen species. Biochemistry (2010) 2.67
Typical 2-Cys peroxiredoxins--structures, mechanisms and functions. FEBS J (2009) 2.57
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. J Biol Chem (2011) 2.25
The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics (2011) 2.16
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10
Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin. Biochemistry (2005) 2.01
Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med (2012) 1.90
Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST. Proc Natl Acad Sci U S A (2004) 1.88
A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway. Proc Natl Acad Sci U S A (2005) 1.87
Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery. J Cell Biol (2006) 1.84
Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins. Antioxid Redox Signal (2011) 1.79
Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling. Biochem J (2005) 1.78
The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. Cell (2009) 1.75
S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.73
Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. Cancer Res (2007) 1.63
Rice NTRC is a high-efficiency redox system for chloroplast protection against oxidative damage. Plant Cell (2006) 1.63
Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. Proc Natl Acad Sci U S A (2004) 1.63
Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin. Proc Natl Acad Sci U S A (2007) 1.62
Cysteine-based redox switches in enzymes. Antioxid Redox Signal (2010) 1.62
Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61. J Biol Chem (2003) 1.61
Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infect Immun (2005) 1.59
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione. J Neurochem (2008) 1.58
Genome analysis of Moraxella catarrhalis strain BBH18, [corrected] a human respiratory tract pathogen. J Bacteriol (2010) 1.57
Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum. EMBO J (2010) 1.56
Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol Aspects Med (2008) 1.56
The in vivo gene expression signature of oxidative stress. Physiol Genomics (2008) 1.55
Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid. Protein Sci (2008) 1.54
The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function. Proc Natl Acad Sci U S A (2006) 1.54
Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. Biochem J (2008) 1.53
Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. Nature (2008) 1.52
The endosymbiont Wolbachia pipientis induces the expression of host antioxidant proteins in an Aedes albopictus cell line. PLoS One (2008) 1.51
Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J (2008) 1.49
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation. J Cell Sci (2010) 1.48
Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations. Exp Eye Res (2008) 1.47
Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization. J Mol Biol (2010) 1.46
Unraveling the secret lives of bacteria: use of in vivo expression technology and differential fluorescence induction promoter traps as tools for exploring niche-specific gene expression. Microbiol Mol Biol Rev (2005) 1.45
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A (2008) 1.44
Cysteine pK(a) values for the bacterial peroxiredoxin AhpC. Biochemistry (2008) 1.42
Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress. J Cell Biochem (2008) 1.42
Peroxiredoxins in plants and cyanobacteria. Antioxid Redox Signal (2011) 1.41
Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal (2010) 1.40
Transcriptome profiling of a toxic dinoflagellate reveals a gene-rich protist and a potential impact on gene expression due to bacterial presence. PLoS One (2010) 1.40
Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis. Proteins (2010) 1.39
Stress-induced protein S-glutathionylation in Arabidopsis. Plant Physiol (2005) 1.37
The thioredoxin system protects ribosomes against stress-induced aggregation. Mol Biol Cell (2005) 1.37
Fungal antioxidant pathways promote survival against neutrophils during infection. J Clin Invest (2012) 1.37
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35
Redox regulation of epidermal growth factor receptor signaling through cysteine oxidation. Biochemistry (2012) 1.35
Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C. Proc Natl Acad Sci U S A (2007) 1.34
Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease. Oxid Med Cell Longev (2013) 1.34
Thioredoxin-linked processes in cyanobacteria are as numerous as in chloroplasts, but targets are different. Proc Natl Acad Sci U S A (2003) 1.33
Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity. Biochem J (2009) 1.32
Oxidative protein folding and the Quiescin-sulfhydryl oxidase family of flavoproteins. Antioxid Redox Signal (2010) 1.31
Analysis and functional prediction of reactive cysteine residues. J Biol Chem (2011) 1.29
Irreversible oxidation of the active-site cysteine of peroxiredoxin to cysteine sulfonic acid for enhanced molecular chaperone activity. J Biol Chem (2008) 1.27
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin. Mol Cells (2009) 1.26
An atlas of the thioredoxin fold class reveals the complexity of function-enabling adaptations. PLoS Comput Biol (2009) 1.26
FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts. J Biol Chem (2008) 1.25
ohrR and ohr are the primary sensor/regulator and protective genes against organic hydroperoxide stress in Agrobacterium tumefaciens. J Bacteriol (2006) 1.25
Redox control systems in the nucleus: mechanisms and functions. Antioxid Redox Signal (2010) 1.25
Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4. J Immunol (2009) 1.24
Oxidative stress in Schizosaccharomyces pombe: different H2O2 levels, different response pathways. Mol Genet Genomics (2006) 1.24
The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence. BMC Genomics (2010) 1.24
Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation. FASEB J (2010) 1.23
Redox regulatory mechanism of transnitrosylation by thioredoxin. Mol Cell Proteomics (2010) 1.23
Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells. Biochem J (2005) 1.22
Mitochondrial reactive oxygen species and cancer. Cancer Metab (2014) 1.20
Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis. Am J Pathol (2006) 1.20
Contribution of the Helicobacter pylori thiol peroxidase bacterioferritin comigratory protein to oxidative stress resistance and host colonization. Infect Immun (2005) 1.20
Redox-regulated chaperones. Biochemistry (2009) 1.19
The Campylobacter jejuni thiol peroxidases Tpx and Bcp both contribute to aerotolerance and peroxide-mediated stress resistance but have distinct substrate specificities. J Bacteriol (2008) 1.19
p53, oxidative stress, and aging. Antioxid Redox Signal (2011) 1.18
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol Cell Biol (2004) 1.18
Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif. Proc Natl Acad Sci U S A (2007) 1.18
Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding. Sci Rep (2013) 1.18
Reduction of cysteine sulfinic acid in eukaryotic, typical 2-Cys peroxiredoxins by sulfiredoxin. Antioxid Redox Signal (2010) 1.17
Peroxiredoxin 6 in human brain: molecular forms, cellular distribution and association with Alzheimer's disease pathology. Acta Neuropathol (2008) 1.17
The Role of Oxidative Stress in Neurodegenerative Diseases. Exp Neurobiol (2015) 1.16
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol (2012) 1.15
Antioxidant responses and cellular adjustments to oxidative stress. Redox Biol (2015) 1.15
Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum. Mol Microbiol (2006) 1.14
Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci (2015) 1.14
Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev (2004) 1.14
Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome. Free Radic Biol Med (2007) 1.13
Crystal structure of reduced and of oxidized peroxiredoxin IV enzyme reveals a stable oxidized decamer and a non-disulfide-bonded intermediate in the catalytic cycle. J Biol Chem (2011) 1.13
Structural changes common to catalysis in the Tpx peroxiredoxin subfamily. J Mol Biol (2009) 1.12
Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase. Aging Cell (2011) 1.12
PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family. Nucleic Acids Res (2010) 1.12
The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Mol Cell Biol (2008) 1.12
A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging. Aging (Albany NY) (2010) 1.12
Peroxiredoxin 6 is required for blood vessel integrity in wounded skin. J Cell Biol (2007) 1.12
Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science (2003) 6.96
Cysteine redox sensor in PKGIa enables oxidant-induced activation. Science (2007) 3.29
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Typical 2-Cys peroxiredoxins--structures, mechanisms and functions. FEBS J (2009) 2.57
Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins. Biochemistry (2002) 2.41
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med (2012) 2.39
Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin. Biochemistry (2005) 2.01
Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery. J Cell Biol (2006) 1.84
Protein sulfenation as a redox sensor: proteomics studies using a novel biotinylated dimedone analogue. Mol Cell Proteomics (2007) 1.81
Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins. Antioxid Redox Signal (2011) 1.79
Novel organic hydroperoxide-sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress. J Bacteriol (2006) 1.64
Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin. Proc Natl Acad Sci U S A (2007) 1.62
Cysteine-based redox switches in enzymes. Antioxid Redox Signal (2010) 1.62
Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61. J Biol Chem (2003) 1.61
Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. J Biol Chem (2006) 1.58
Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid. Protein Sci (2008) 1.54
Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization. J Mol Biol (2010) 1.46
Cysteine pK(a) values for the bacterial peroxiredoxin AhpC. Biochemistry (2008) 1.42
The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. J Immunol (2007) 1.41
Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis. Proteins (2010) 1.39
An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum. Biochemistry (2002) 1.38
Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species. Proc Natl Acad Sci U S A (2011) 1.38
Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice. PLoS One (2010) 1.36
Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Methods Enzymol (2010) 1.33
An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro. J Bacteriol (2002) 1.32
Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins. Methods Enzymol (2010) 1.23
Water-soluble triarylphosphines as biomarkers for protein S-nitrosation. ACS Chem Biol (2010) 1.16
Structural changes common to catalysis in the Tpx peroxiredoxin subfamily. J Mol Biol (2009) 1.12
PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family. Nucleic Acids Res (2010) 1.12
Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. Biochemistry (2005) 1.09
Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF. Protein Sci (2005) 1.08
Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity. Mol Cell (2008) 1.07
Glyceraldehyde 3-phosphate dehydrogenase is unlikely to mediate hydrogen peroxide signaling: studies with a novel anti-dimedone sulfenic acid antibody. Antioxid Redox Signal (2010) 1.04
Tuning of peroxiredoxin catalysis for various physiological roles. Biochemistry (2014) 1.02
Peroxiredoxins in parasites. Antioxid Redox Signal (2012) 1.01
Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin. Biochemistry (2011) 1.01
Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme. Biochemistry (2004) 1.01
Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins. Chem Commun (Camb) (2011) 1.00
Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum. Proc Natl Acad Sci U S A (2010) 0.99
Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. J Biol Chem (2012) 0.98
Cysteine reactivity and thiol-disulfide interchange pathways in AhpF and AhpC of the bacterial alkyl hydroperoxide reductase system. Biochemistry (2007) 0.98
Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates. Methods Enzymol (2013) 0.97
Chemical approaches to detect and analyze protein sulfenic acids. Mass Spectrom Rev (2013) 0.96
Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes. Biochemistry (2012) 0.95
A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes. Chem Commun (Camb) (2012) 0.95
Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis. Free Radic Res (2011) 0.95
Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids. FEBS J (2013) 0.94
Strained cycloalkynes as new protein sulfenic acid traps. J Am Chem Soc (2014) 0.94
Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2). Free Radic Biol Med (2008) 0.94
Formation, TEM study and 3D reconstruction of the human erythrocyte peroxiredoxin-2 dodecahedral higher-order assembly. Micron (2006) 0.93
Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells. Free Radic Biol Med (2010) 0.92
Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines. Biochim Biophys Acta (2003) 0.89
Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase. Biochemistry (2002) 0.89
Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack. Mol Cell (2012) 0.88
The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation. Eur J Immunol (2012) 0.87
Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Biochemistry (2015) 0.87
The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin. Biochemistry (2013) 0.87
Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase. J Biomol Struct Dyn (2010) 0.86
Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem (2007) 0.85
D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing. J Bacteriol (2013) 0.83
Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family. BMC Struct Biol (2011) 0.82
Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers. J Phys Chem B (2012) 0.81
Engineering of fluorescent reporters into redox domains to monitor electron transfers. Methods Enzymol (2010) 0.80
The role of erythrocyte peroxiredoxin in detoxifying peroxides and in stimulating potassium efflux via the Gardos channels. Blood (2003) 0.78
RNA ligase; picking up the pieces. Mol Cell (2004) 0.77
Topology of the 10 subunits within the decamer of KLH, the hemocyanin of the marine gastropod Megathura crenulata. J Struct Biol (2002) 0.77
Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase. Methods Mol Biol (2008) 0.76
Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry. Int J Mass Spectrom (2011) 0.76
Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses. J Virol (2012) 0.76
Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Biochemistry (2009) 0.75
Electrostatics of cysteine residues in proteins: parameterization and validation of a simple model. Proteins (2012) 0.75