Published in Biochim Biophys Acta on December 24, 2015
Clinical significance of T cell metabolic reprogramming in cancer. Clin Transl Med (2016) 0.79
Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells. Oncotarget (2016) 0.77
K-Ras Activation Induces Differential Sensitivity to Sulfur Amino Acid Limitation and Deprivation and to Oxidative and Anti-Oxidative Stress in Mouse Fibroblasts. PLoS One (2016) 0.75
Regulation and function of the SLC38A3/SNAT3 glutamine transporter. Channels (Austin) (2016) 0.75
Targeting metabolic reprogramming in KRAS-driven cancers. Int J Clin Oncol (2017) 0.75
Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism. Oncogenesis (2017) 0.75
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature (2005) 12.56
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71
Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol (2008) 11.05
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature (2004) 6.02
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature (2007) 4.14
Amino acid signalling upstream of mTOR. Nat Rev Mol Cell Biol (2013) 3.36
The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases. J Cell Physiol (2008) 3.05
X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature (2013) 3.00
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther (2008) 2.79
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Arch (2003) 2.66
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer. J Neurochem (2006) 2.18
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity (2014) 2.14
Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc Natl Acad Sci U S A (1999) 1.93
Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell (1999) 1.79
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell (2013) 1.73
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. Cancer Cell (2015) 1.70
Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. J Biol Chem (2000) 1.66
Glutamine and glutamate--their central role in cell metabolism and function. Cell Biochem Funct (2003) 1.59
Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance. Am J Physiol Cell Physiol (2007) 1.59
The metabolic fates of amino acids and the formation of glutamine in skeletal muscle. J Biol Chem (1978) 1.47
Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder. Nat Genet (2004) 1.45
Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis-derived endogenous glutamine production. Am J Clin Nutr (1999) 1.43
Pathophysiology and treatment of cystinuria. Nat Rev Nephrol (2010) 1.40
The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med (2013) 1.36
Effect of exercise on protein turnover in man. Clin Sci (Lond) (1981) 1.29
Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat Genet (2004) 1.27
Hepatic glutamate metabolism: a tale of 2 hepatocytes. Am J Clin Nutr (2009) 1.27
Specific PET imaging of xC- transporter activity using a ¹⁸F-labeled glutamate derivative reveals a dominant pathway in tumor metabolism. Clin Cancer Res (2011) 1.27
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis. Nat Genet (2012) 1.26
Control of glutamine metabolism by the tumor suppressor Rb. Oncogene (2013) 1.25
Targeting glutamine transport to suppress melanoma cell growth. Int J Cancer (2014) 1.21
Expression of a system L neutral amino acid transporter at the blood-brain barrier. Neuroreport (2000) 1.17
Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. J Biol Chem (2000) 1.15
Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem (2011) 1.15
Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis. Hum Mol Genet (2003) 1.15
The SLC6A14 gene shows evidence of association with obesity. J Clin Invest (2003) 1.15
The solute carrier 6 family of transporters. Br J Pharmacol (2012) 1.14
Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development. J Pathol (2015) 1.12
Role of amino acid transporters in amino acid sensing. Am J Clin Nutr (2013) 1.11
Cloning and functional characterization of a new subtype of the amino acid transport system N. Am J Physiol Cell Physiol (2001) 1.10
Placental nutrient supply and fetal growth. Int J Dev Biol (2010) 1.09
Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells. Invest Ophthalmol Vis Sci (2005) 1.08
ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene (2015) 1.06
The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med (2013) 1.05
HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol Cell (2012) 1.05
Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. Biochem Biophys Res Commun (2001) 1.05
Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta. Biochem Biophys Res Commun (2000) 1.04
ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation. J Pathol (2014) 1.04
Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. Biochem J (2008) 1.02
The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch (2013) 1.02
Lysinuric protein intolerance: update and extended mutation analysis of the SLC7A7 gene. Hum Mutat (2008) 1.02
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis. Nat Commun (2015) 1.01
SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. J Biol Chem (2011) 0.99
Characterization of tryptophan transport in human placental brush-border membrane vesicles. Biochem J (1986) 0.99
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans. Biochim Biophys Acta (2005) 0.99
Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs. Cancer Res (2015) 0.98
Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix. Gynecol Oncol (2005) 0.97
Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. Diabetes (2004) 0.97
Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse. J Biol Chem (2011) 0.97
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health. Front Chem (2014) 0.96
L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res (2015) 0.95
Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord (2005) 0.95
Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8. Biochem J (2011) 0.94
The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS One (2014) 0.92
Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer. Int J Cancer (2015) 0.91
The SLC38 family of sodium-amino acid co-transporters. Pflugers Arch (2013) 0.91
Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer. Int J Clin Exp Pathol (2014) 0.89
Detection of elafin as a candidate biomarker for ulcerative colitis by whole-genome microarray screening. Inflamm Bowel Dis (2006) 0.88
Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells. Invest Ophthalmol Vis Sci (2008) 0.85
Plasma glutamine and glutamate concentrations in Gabonese children with Plasmodium falciparum infection. QJM (2002) 0.85
Intestinal peptidases form functional complexes with the neutral amino acid transporter B(0)AT1. Biochem J (2012) 0.84
Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS. J Mol Biol (2014) 0.84
Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening. PLoS Comput Biol (2015) 0.83
Gene expression alterations in ulcerative colitis patients after restorative proctocolectomy extend to the small bowel proximal to the pouch. Gut (2014) 0.81
The Amino Acid Transporters of the Glutamate/GABA-Glutamine Cycle and Their Impact on Insulin and Glucagon Secretion. Front Endocrinol (Lausanne) (2013) 0.80
Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. Biochem J (2015) 0.80
Collectrin and ACE2 in renal and intestinal amino acid transport. Channels (Austin) (2011) 0.78
Identification and characterization of the gene expression profiles for protein coding and non-coding RNAs of pancreatic ductal adenocarcinomas. Oncotarget (2015) 0.78
SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children. Clin Biochem (2015) 0.76
Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney. Pflugers Arch (2015) 0.76
Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma. Biomed Res Int (2015) 0.75
Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain. Immunity (2015) 0.79
Unconventional Functions of Amino Acid Transporters: Role in Macropinocytosis (SLC38A5/SLC38A3) and Diet-Induced Obesity/Metabolic Syndrome (SLC6A19/SLC6A14/SLC6A6). Biomolecules (2022) 0.75
Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer. Biochim Biophys Acta (2017) 0.75