Published in J Biol Chem on April 21, 2011
The Concise Guide to PHARMACOLOGY 2013/14: transporters. Br J Pharmacol (2013) 2.07
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature (2015) 2.01
Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism. Am J Hum Genet (2013) 1.53
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Mol Cell Biol (2015) 1.27
An extended proteome map of the lysosomal membrane reveals novel potential transporters. Mol Cell Proteomics (2013) 1.13
Role of amino acid transporters in amino acid sensing. Am J Clin Nutr (2013) 1.11
Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes. J Physiol (2012) 1.08
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health. Front Chem (2014) 0.96
The SLC38 family of sodium-amino acid co-transporters. Pflugers Arch (2013) 0.91
Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in Drosophila. Proc Natl Acad Sci U S A (2014) 0.89
Effects of different tissue microenvironments on gene expression in breast cancer cells. PLoS One (2014) 0.84
Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system. BMC Neurosci (2013) 0.83
Brain interstitial fluid glutamine homeostasis is controlled by blood-brain barrier SLC7A5/LAT1 amino acid transporter. J Cereb Blood Flow Metab (2015) 0.82
Glutamine transporters in mammalian cells and their functions in physiology and cancer. Biochim Biophys Acta (2015) 0.82
Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapses. PLoS One (2014) 0.81
B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain. PLoS One (2013) 0.80
Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. J Biol Chem (2011) 0.80
Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter. PLoS One (2013) 0.76
Placental accommodations for transport and metabolism during intra-uterine crowding in pigs. J Anim Sci Biotechnol (2014) 0.75
The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation. FEBS Open Bio (2017) 0.75
Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification. PLoS One (2016) 0.75
Regulation and function of the SLC38A3/SNAT3 glutamine transporter. Channels (Austin) (2016) 0.75
The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet. PLoS One (2017) 0.75
Regulation of lysosomal ion homeostasis by channels and transporters. Sci China Life Sci (2016) 0.75
A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice. Biochem Pharmacol (2016) 0.75
The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission. FEBS Open Bio (2017) 0.75
Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in Schizophrenia. Front Psychiatry (2017) 0.75
Glutamate uptake. Prog Neurobiol (2001) 13.59
NeuN, a neuronal specific nuclear protein in vertebrates. Development (1992) 10.82
A 38,000-dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci U S A (1985) 4.35
Identification and characterization of the vesicular GABA transporter. Nature (1997) 4.26
Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev (1990) 3.82
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest (2006) 3.81
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch (2003) 3.76
Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem (1991) 2.66
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Arch (2003) 2.66
Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell (1995) 2.61
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proc Natl Acad Sci U S A (1997) 2.12
Differences in the cellular distributions of two microtubule-associated proteins, MAP1 and MAP2, in rat brain. J Neurosci (1984) 2.08
The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav (2002) 1.89
Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell (1999) 1.79
Nitrogen metabolism in liver: structural and functional organization and physiological relevance. Biochem J (1990) 1.76
Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. Am J Physiol Endocrinol Metab (2009) 1.68
Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A. J Biol Chem (2000) 1.66
Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics (2009) 1.62
Cloning and functional identification of a neuronal glutamine transporter. J Biol Chem (2000) 1.60
Transfer of glutamine between astrocytes and neurons. J Neurochem (2001) 1.58
The glutamine commute: take the N line and transfer to the A. J Cell Biol (2002) 1.56
A novel system A isoform mediating Na+/neutral amino acid cotransport. J Biol Chem (2000) 1.47
Glutamine uptake by neurons: interaction of protons with system a transporters. J Neurosci (2002) 1.37
SNAT4 isoform of system A amino acid transporter is expressed in human placenta. Am J Physiol Cell Physiol (2005) 1.35
The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS Lett (2008) 1.34
Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: immunogold evidence from hippocampal slice cultures. J Neurochem (1995) 1.29
Glutamine and glutamate as vital metabolites. Braz J Med Biol Res (2003) 1.26
Amino acid transport system A resembles system N in sequence but differs in mechanism. Proc Natl Acad Sci U S A (2000) 1.26
In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney. Drug Metab Pharmacokinet (2009) 1.23
Compartmentation of brain glutamate metabolism in neurons and glia. J Nutr (2000) 1.22
Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta (2000) 1.20
Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons. J Biol Chem (2003) 1.17
The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. J Mol Neurosci (2008) 1.16
Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. J Biol Chem (2000) 1.15
Molecular cloning and primary structure of human glial fibrillary acidic protein. Proc Natl Acad Sci U S A (1989) 1.14
Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. J Neurochem (2003) 1.13
Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim Biophys Acta (2001) 1.12
Cloning and functional characterization of a new subtype of the amino acid transport system N. Am J Physiol Cell Physiol (2001) 1.10
On the strategy of kinetic discrimination of amino acid transport systems. J Membr Biol (1985) 1.08
The identification of neutral amino acid transport systems. Exp Physiol (1990) 1.08
Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex. Cereb Cortex (2004) 1.05
Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. Biochem Biophys Res Commun (2001) 1.05
Identification and characterization of an amino acid transporter expressed differentially in liver. Proc Natl Acad Sci U S A (2000) 1.02
The glutamine commute: lost in the tube? Neurochem Int (2006) 1.01
TGFbeta induces SIK to negatively regulate type I receptor kinase signaling. J Cell Biol (2008) 0.99
Amino acid transporter SNAT5 localizes to glial cells in the rat brain. Glia (2005) 0.98
Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport. J Biol Chem (2001) 0.96
The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. Biophys J (2007) 0.95
Utilization of glutamine and of TCA cycle constituents as precursors for transmitter glutamate and GABA. Dev Neurosci (1993) 0.95
Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain. Neuroscience (2005) 0.94
Glutamine and glutamate metabolism across the liver sinusoid. J Nutr (2000) 0.91
Identification of a system N-like Na(+)-dependent glutamine transport activity in rat brain neurons. J Neurochem (1997) 0.89
Localization and functional relevance of system a neutral amino acid transporters in cultured hippocampal neurons. J Biol Chem (2002) 0.87
Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells. Invest Ophthalmol Vis Sci (2008) 0.85
Functional expression and adaptive regulation of Na+ -dependent neutral amino acid transporter SNAT2/ATA2 in normal human astrocytes under amino acid starved condition. Neurosci Lett (2005) 0.83
A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Genomics (2001) 0.83
Glucocorticoid hormone-induced receptor localization to the chromatin fibers formed on injected DNA in Xenopus oocytes. Exp Cell Res (2001) 0.78
Many QTLs with minor additive effects are associated with a large difference in growth between two selection lines in chickens. Genet Res (2005) 2.07
Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin. BMC Biol (2009) 2.07
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics (2004) 1.90
Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics (2006) 1.80
The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene. Genetics (2004) 1.57
Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. Genomics (2006) 1.55
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun (2008) 1.55
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci (2009) 1.48
The G protein-coupled receptor subset of the rat genome. BMC Genomics (2007) 1.45
Structure and flexibility of individual immunoglobulin G molecules in solution. Structure (2004) 1.41
Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. Genomics (2012) 1.36
G protein-coupled receptor deorphanizations. Annu Rev Pharmacol Toxicol (2012) 1.33
Comparison of the current RefSeq, Ensembl and EST databases for counting genes and gene discovery. FEBS Lett (2005) 1.30
The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. PLoS One (2012) 1.23
SPRIT: Identifying horizontal gene transfer in rooted phylogenetic trees. BMC Evol Biol (2010) 1.23
The G protein-coupled receptor subset of the chicken genome. PLoS Comput Biol (2006) 1.20
The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene (2005) 1.18
The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish. Mol Phylogenet Evol (2005) 1.18
Independent HHsearch, Needleman--Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families. Mol Biol Evol (2011) 1.17
FoxA1 binding to the MMTV LTR modulates chromatin structure and transcription. Exp Cell Res (2004) 1.16
The GRAFS classification system of G-protein coupled receptors in comparative perspective. Gen Comp Endocrinol (2005) 1.16
The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. J Mol Neurosci (2008) 1.16
The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs. Mol Biol Evol (2003) 1.16
The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924. BMC Med Genet (2009) 1.16
Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim Biophys Acta (2005) 1.11
The dispanins: a novel gene family of ancient origin that contains 14 human members. PLoS One (2012) 1.11
The repertoire of solute carriers of family 6: identification of new human and rodent genes. Biochem Biophys Res Commun (2005) 1.09
Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics (2007) 1.09
The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors. BMC Evol Biol (2008) 1.09
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children. BMC Med Genet (2010) 1.09
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med (2013) 1.08
The Secretin GPCRs descended from the family of Adhesion GPCRs. Mol Biol Evol (2008) 1.07
FoxA1 binding directs chromatin structure and the functional response of a glucocorticoid receptor-regulated promoter. Mol Cell Biol (2009) 1.07
Increased mRNA levels of tyrosine hydroxylase and dopamine transporter in the VTA of male rats after chronic food restriction. Eur J Neurosci (2006) 1.04
Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function. J Neurosci (2009) 1.04
Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickens. J Bone Miner Res (2007) 1.04
Histone acetylation characterizes chromatin presetting by NF1 and Oct1 and enhances glucocorticoid receptor binding to the MMTV promoter. Exp Cell Res (2009) 1.02
Association of feather colour with constitutively active melanocortin 1 receptors in chicken. Eur J Biochem (2003) 1.01
Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. Genomics (2008) 1.01
The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents. BMC Genomics (2009) 1.00
Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake. Endocrinology (2010) 0.99
Evolutionary conservation of the structural, pharmacological, and genomic characteristics of the melanocortin receptor subtypes. Peptides (2005) 0.99
Chicken genomics: feather-pecking and victim pigmentation. Nature (2004) 0.99
Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. Gene (2010) 0.98
The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species. Mol Biol Evol (2010) 0.97
Genetic algorithm for large-scale maximum parsimony phylogenetic analysis of proteins. Biochim Biophys Acta (2005) 0.97
Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci (2008) 0.96
One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. J Neurochem (2002) 0.96
The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men. Neurobiol Aging (2011) 0.95
What model organisms and interactomics can reveal about the genetics of human obesity. Cell Mol Life Sci (2012) 0.95
Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY. Peptides (2008) 0.94
The phylogenetic relationship of the glutamate and pheromone G-protein-coupled receptors in different vertebrate species. Ann N Y Acad Sci (2005) 0.94
Mechanism of histone H1-stimulated glucocorticoid receptor DNA binding in vivo. Mol Cell Biol (2007) 0.92
Solute carriers as drug targets: current use, clinical trials and prospective. Mol Aspects Med (2013) 0.92
Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: evolution and tissue expression. BMC Genomics (2010) 0.92
Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly. PLoS One (2011) 0.91
Differential regulation of nuclear receptors, neuropeptides and peptide hormones in the hypothalamus and pituitary of food restricted rats. Brain Res Mol Brain Res (2005) 0.90
Nuclear factor 1 and octamer transcription factor 1 binding preset the chromatin structure of the mouse mammary tumor virus promoter for hormone induction. J Biol Chem (2004) 0.90
Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae. BMC Evol Biol (2011) 0.89
Regulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila. Genetics (2013) 0.89
Critical evaluation of the FANTOM3 non-coding RNA transcripts. Genomics (2009) 0.89
Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes. BMC Evol Biol (2007) 0.88
Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors. Mol Phylogenet Evol (2006) 0.88
The relative impact of chronic food restriction and acute food deprivation on plasma hormone levels and hypothalamic neuropeptide expression. Peptides (2008) 0.87
Identification of novel splice variants of Adhesion G protein-coupled receptors. Gene (2006) 0.87
Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system. Eur J Biochem (2003) 0.87
Chromatin-mediated restriction of nuclear factor 1/CTF binding in a repressed and hormone-activated promoter in vivo. Mol Cell Biol (2004) 0.87
Allelotyping by massively parallel pyrosequencing of SNP-carrying trinucleotide threads. Hum Mutat (2008) 0.87
Remarkable similarities between the hemichordate (Saccoglossus kowalevskii) and vertebrate GPCR repertoire. Gene (2013) 0.86
The adhesion GPCRs; gene repertoire, phylogeny and evolution. Adv Exp Med Biol (2010) 0.85
Remarkable synteny conservation of melanocortin receptors in chicken, human, and other vertebrates. Genomics (2003) 0.85
High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3. J Biol Chem (2003) 0.85
Synaptic changes induced by melanocortin signalling. Nat Rev Neurosci (2014) 0.84
Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. Genomics (2005) 0.84
Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes. Biochem J (2004) 0.84
The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children. BMC Med Genet (2012) 0.83
C6ORF192 forms a unique evolutionary branch among solute carriers (SLC16, SLC17, and SLC18) and is abundantly expressed in several brain regions. J Mol Neurosci (2009) 0.83
Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system. BMC Neurosci (2013) 0.83
Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans. PLoS Genet (2012) 0.83
Fto immunoreactivity is widespread in the rodent brain and abundant in feeding-related sites, but the number of Fto-positive cells is not affected by changes in energy balance. Physiol Behav (2011) 0.81
Reciprocal mutations of neuropeptide Y receptor Y2 in human and chicken identify amino acids important for antagonist binding. FEBS Lett (2002) 0.81
Genome-wide analysis shows association of epigenetic changes in regulators of Rab and Rho GTPases with spinal muscular atrophy severity. Eur J Hum Genet (2013) 0.81
The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury. BMC Neurosci (2008) 0.81
The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children. PLoS One (2013) 0.80
Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression. Biochem Biophys Res Commun (2011) 0.80
B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain. PLoS One (2013) 0.80
Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes. PLoS One (2013) 0.80
Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats. Eur J Hum Genet (2011) 0.80
Comprehensive analysis of localization of 78 solute carrier genes throughout the subsections of the rat gastrointestinal tract. Biochem Biophys Res Commun (2011) 0.80
Functional role, structure, and evolution of the melanocortin-4 receptor. Ann N Y Acad Sci (2003) 0.80
The Chironomus tentans translation initiation factor eIF4H is present in the nucleus but does not bind to mRNA until the mRNA reaches the cytoplasmic perinuclear region. J Cell Sci (2003) 0.79
Early vertebrate origin of melanocortin 2 receptor accessory proteins (MRAPs). Gen Comp Endocrinol (2013) 0.79
In Situ Proximity Ligation Assay (PLA). Methods Mol Biol (2015) 0.79
Identification of distant Agouti-like sequences and re-evaluation of the evolutionary history of the Agouti-related peptide (AgRP). PLoS One (2012) 0.79
Polymorphisms in sh2b1 and spns1 loci are associated with triglyceride levels in a healthy population in northern Sweden. J Genet (2012) 0.78