Published in Sci Rep on January 05, 2016
Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis. BMC Gastroenterol (2017) 0.75
Analysis of Differentially Expressed Genes in Gastrocnemius Muscle between DGAT1 Transgenic Mice and Wild-Type Mice. Biomed Res Int (2017) 0.75
Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation. PLoS One (2017) 0.75
Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis. Drug Metab Dispos (2016) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
On the origin of cancer cells. Science (1956) 49.55
On respiratory impairment in cancer cells. Science (1956) 14.07
Cancer cell metabolism: Warburg and beyond. Cell (2008) 11.80
Bile acids: natural ligands for an orphan nuclear receptor. Science (1999) 7.18
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science (2006) 5.52
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell (1999) 4.76
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res (2007) 3.37
BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J Lipid Res (2002) 2.26
Extraction and GC/MS analysis of the human blood plasma metabolome. Anal Chem (2005) 2.13
Tissue metabolomics of hepatocellular carcinoma: tumor energy metabolism and the role of transcriptomic classification. Hepatology (2013) 1.85
Targeting glucose metabolism for cancer therapy. J Exp Med (2012) 1.64
Dynamics of nuclear receptor target gene regulation. Chromosoma (2010) 1.63
Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res (2008) 1.61
FXR: a metabolic regulator and cell protector. Cell Res (2008) 1.59
Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis. Toxicol Appl Pharmacol (2005) 1.31
FXR regulates liver repair after CCl4-induced toxic injury. Mol Endocrinol (2010) 1.23
Bile acids activate YAP to promote liver carcinogenesis. Cell Rep (2013) 1.14
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. Cancer Res (2008) 1.14
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochem Pharmacol (2007) 1.13
Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Mol Endocrinol (2010) 1.11
Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance. Pharm Res (2013) 1.07
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice. Hepatology (2012) 1.04
Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology (2012) 1.02
Role of bile acids in liver injury and regeneration following acetaminophen overdose. Am J Pathol (2013) 0.99
Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor. Biochem Biophys Res Commun (2005) 0.97
Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels. Cell Metab (2014) 0.97
PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun (2014) 0.94
Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem (2005) 0.93
Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition. FASEB J (2012) 0.88
PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade. J Biol Chem (2014) 0.88
Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α. Mol Endocrinol (2011) 0.85
Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation. J Biochem (2012) 0.84
Prometheus' little helper, a novel role for fibroblast growth factor 15 in compensatory liver growth. J Hepatol (2013) 0.80
Insights into drug discovery from natural medicines using reverse pharmacokinetics. Trends Pharmacol Sci (2014) 0.83
Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation. Chin J Nat Med (2013) 0.77
Clinicalpathological and prognostic significance of survivin expression in renal cell carcinoma: a meta-analysis. Oncotarget (2017) 0.75
De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells. Oncotarget (2016) 0.75
Effects of diammonium glycyrrhizinate on hepatic and intestinal UDP-Glucuronosyltransferases in rats: Implication in herb-drug interactions. Chin J Nat Med (2016) 0.75