Published in Science on April 14, 2006
Liver regeneration. J Cell Physiol (2007) 6.69
Bile acids: regulation of synthesis. J Lipid Res (2009) 4.31
Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol (2009) 3.55
Stem cells and liver regeneration. Gastroenterology (2009) 3.40
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med (2015) 2.86
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology (2008) 2.79
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol (2009) 2.76
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab (2009) 2.27
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis (2006) 2.18
The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor. Hepatology (2008) 1.90
Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts. Am J Pathol (2009) 1.87
Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms. Arch Biochem Biophys (2007) 1.75
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. BMC Cancer (2010) 1.58
Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab (2014) 1.54
Deciphering the nuclear bile acid receptor FXR paradigm. Nucl Recept Signal (2010) 1.53
Bile acids: chemistry, physiology, and pathophysiology. World J Gastroenterol (2009) 1.51
Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis. Gastroenterology (2013) 1.50
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol (2009) 1.49
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One (2010) 1.45
Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers. Gastroenterology (2015) 1.44
Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 1.42
Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice. J Biol Chem (2012) 1.42
Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid. Am J Physiol Gastrointest Liver Physiol (2010) 1.38
Increased activation of the Wnt/β-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice. J Pharmacol Exp Ther (2011) 1.36
The bile salt export pump. Pflugers Arch (2006) 1.34
Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A (2013) 1.33
Bile acid transporters and regulatory nuclear receptors in the liver and beyond. J Hepatol (2012) 1.30
Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology (2010) 1.29
Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proc Natl Acad Sci U S A (2007) 1.29
Hepatic stem cell niches. J Clin Invest (2013) 1.29
The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci (2013) 1.28
The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem (2008) 1.27
Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway. Proc Natl Acad Sci U S A (2011) 1.25
FXR regulates liver repair after CCl4-induced toxic injury. Mol Endocrinol (2010) 1.23
Inflammation and fibrogenesis in steatohepatitis. J Gastroenterol (2012) 1.21
FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem (2009) 1.19
"State of the art" in liver resection and living donor liver transplantation: a worldwide survey of 100 liver centers. World J Surg (2009) 1.18
Intracellular signaling and hepatocellular carcinoma. Semin Cancer Biol (2010) 1.17
Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest (2010) 1.17
Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications. Biochim Biophys Acta (2010) 1.15
Bile acids activate YAP to promote liver carcinogenesis. Cell Rep (2013) 1.14
TGR5: a novel target for weight maintenance and glucose metabolism. Exp Diabetes Res (2011) 1.12
Mechanisms limiting body growth in mammals. Endocr Rev (2011) 1.12
External biliary drainage following major liver resection for perihilar cholangiocarcinoma: impact on development of liver failure and biliary leakage. HPB (Oxford) (2016) 1.12
Glycogen synthase kinase 3 β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration. Proc Natl Acad Sci U S A (2011) 1.11
Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation. Am J Pathol (2012) 1.10
Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice. Hepatology (2012) 1.09
Sterol regulation of metabolism, homeostasis, and development. Annu Rev Biochem (2011) 1.08
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression. Mol Endocrinol (2012) 1.08
Circadian dysregulation disrupts bile acid homeostasis. PLoS One (2009) 1.07
Nuclear receptors as therapeutic targets in cholestatic liver diseases. Br J Pharmacol (2009) 1.07
Recent advances in the development of farnesoid X receptor agonists. Ann Transl Med (2015) 1.06
Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol (2008) 1.05
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice. Hepatology (2012) 1.04
Farnesoid X receptor protects hepatocytes from injury by repressing miR-199a-3p, which increases levels of LKB1. Gastroenterology (2012) 1.03
Endocrine and paracrine role of bile acids. World J Gastroenterol (2008) 1.02
Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology (2012) 1.02
Elucidating the metabolic regulation of liver regeneration. Am J Pathol (2013) 1.01
FXR protects lung from lipopolysaccharide-induced acute injury. Mol Endocrinol (2011) 1.00
Role of bile acids in liver injury and regeneration following acetaminophen overdose. Am J Pathol (2013) 0.99
Functional Relationships between Lipid Metabolism and Liver Regeneration. Int J Hepatol (2012) 0.97
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis. J Lipid Res (2011) 0.96
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling. Hepatology (2014) 0.96
BMP4 is a novel paracrine inhibitor of liver regeneration. Am J Physiol Gastrointest Liver Physiol (2012) 0.95
Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma. Am J Physiol Gastrointest Liver Physiol (2012) 0.95
Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer. J Hepatol (2015) 0.95
PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun (2014) 0.94
Signals and cells involved in regulating liver regeneration. Cells (2012) 0.94
FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9. Arterioscler Thromb Vasc Biol (2009) 0.94
The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J Physiol Gastrointest Liver Physiol (2009) 0.94
Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis. Hepatology (2010) 0.93
Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex. J Biol Chem (2009) 0.93
Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet? Annu Rev Pharmacol Toxicol (2016) 0.93
Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol (2014) 0.93
Tob1 is a constitutively expressed repressor of liver regeneration. J Exp Med (2010) 0.92
Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse livers. Am J Pathol (2009) 0.92
The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology (2013) 0.92
FXR and liver carcinogenesis. Acta Pharmacol Sin (2014) 0.91
FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One (2012) 0.91
Differential modulation of farnesoid X receptor signaling pathway by the thiazolidinediones. J Pharmacol Exp Ther (2009) 0.91
To divide or not to divide: revisiting liver regeneration. Cell Div (2013) 0.91
Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. PLoS One (2012) 0.90
Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice. Am J Physiol Gastrointest Liver Physiol (2009) 0.90
Cascades of transcription regulation during liver regeneration. Int J Biochem Cell Biol (2010) 0.89
Bile acid flux is necessary for normal liver regeneration. PLoS One (2014) 0.88
Bile Acid Receptors and Liver Cancer. Curr Pathobiol Rep (2012) 0.88
Clinical application of transcriptional activators of bile salt transporters. Mol Aspects Med (2013) 0.87
Ageing Fxr deficient mice develop increased energy expenditure, improved glucose control and liver damage resembling NASH. PLoS One (2013) 0.86
Stem cells for liver repopulation. Curr Opin Organ Transplant (2009) 0.86
Bile acid signaling and liver regeneration. Biochim Biophys Acta (2014) 0.85
Proteomics for the discovery of nuclear bile acid receptor FXR targets. Biochim Biophys Acta (2011) 0.85
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression. J Lipid Res (2008) 0.85
Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice. Proc Natl Acad Sci U S A (2014) 0.85
Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. Biol Pharm Bull (2009) 0.85
Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy. PLoS One (2010) 0.85
Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer. Adv Pharmacol (2015) 0.85
Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor. J Lipid Res (2013) 0.84
Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. J Biol Chem (2012) 0.84
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
Urinary-cell mRNA profile and acute cellular rejection in kidney allografts. N Engl J Med (2013) 7.40
Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet (2010) 7.11
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res (2013) 6.89
Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature (2006) 6.78
Adaptive particle swarm optimization. IEEE Trans Syst Man Cybern B Cybern (2009) 6.47
Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis. Curr Biol (2005) 5.99
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
Predialysis nephrology care of older patients approaching end-stage renal disease. Arch Intern Med (2011) 5.11
Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs). Genome Res (2007) 4.99
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science (2007) 4.68
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
Electrochemical energy storage for green grid. Chem Rev (2011) 4.48
Towards a transgenic model of Huntington's disease in a non-human primate. Nature (2008) 4.47
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature (2011) 4.44
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell (2012) 4.18
Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA (2009) 3.86
Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA (2010) 3.85
Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke (2008) 3.81
Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance. Curr Biol (2003) 3.77
Altitude and all-cause mortality in incident dialysis patients. JAMA (2009) 3.62
The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab (2010) 3.61
Redundant pathways for negative feedback regulation of bile acid production. Dev Cell (2002) 3.51
TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity (2002) 3.46
Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest (2006) 3.44
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res (2007) 3.37
Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study. Acad Radiol (2005) 3.33
HEN1 functions pleiotropically in Arabidopsis development and acts in C function in the flower. Development (2002) 3.24
Respiratory morbidity in late preterm births. JAMA (2010) 3.11
A global reference for fetal-weight and birthweight percentiles. Lancet (2011) 3.05
Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc Natl Acad Sci U S A (2003) 3.02
Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA (2011) 3.02
Macrosomia in 23 developing countries: an analysis of a multicountry, facility-based, cross-sectional survey. Lancet (2013) 2.89
Tube Formation in Nanoscale Materials. Nanoscale Res Lett (2008) 2.83
The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A (2008) 2.82
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol (2011) 2.81
Size distributions of maternal and fetal DNA in maternal plasma. Clin Chem (2004) 2.79
Complex and oriented ZnO nanostructures. Nat Mater (2003) 2.75
Comparative mortality risk of anemia management practices in incident hemodialysis patients. JAMA (2010) 2.71
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science (2002) 2.66
The increasing prevalence of atrial fibrillation among hemodialysis patients. J Am Soc Nephrol (2011) 2.61
Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology (2009) 2.60
Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies. Eur J Cancer (2011) 2.59
Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2005) 2.57
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (2007) 2.53
Challenges in the development of high protein concentration formulations. J Pharm Sci (2004) 2.52
Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria. Circ Res (2003) 2.52
Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes. Mol Biol Cell (2004) 2.50
Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Mol Cell Biol (2010) 2.47
Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A (2003) 2.44
Labor progression and risk of cesarean delivery in electively induced nulliparas. Obstet Gynecol (2005) 2.44
Primary fascial closure with mesh reinforcement is superior to bridged mesh repair for abdominal wall reconstruction. J Am Coll Surg (2013) 2.42
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell (2010) 2.40
Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu. Arch Neurol (2005) 2.39
Electronic origin of high-temperature superconductivity in single-layer FeSe superconductor. Nat Commun (2012) 2.37
Phase diagram and electronic indication of high-temperature superconductivity at 65 K in single-layer FeSe films. Nat Mater (2013) 2.34
NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. PLoS Pathog (2009) 2.32
The research implications of the selection of a gestational age estimation method. Paediatr Perinat Epidemiol (2007) 2.29
Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors. J Clin Oncol (2011) 2.29
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol (2003) 2.26
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine. Proc Natl Acad Sci U S A (2002) 2.24
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. Am J Gastroenterol (2010) 2.20
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell (2003) 2.20
Mapping the murine cardiac 26S proteasome complexes. Circ Res (2006) 2.17
Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell (2013) 2.16
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A (2010) 2.16
Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. J Biol Chem (2004) 2.16
Effect of c-erbB2 overexpression on prognosis in osteosarcoma: evidence from eight studies. Tumour Biol (2014) 2.14
Reduced incidence of breast cancer-related lymphedema following mastectomy and breast reconstruction versus mastectomy alone. Plast Reconstr Surg (2012) 2.13
HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control. J Immunol (2010) 2.10
Lipofilling of the Breast Does Not Increase the Risk of Recurrence of Breast Cancer: A Matched Controlled Study. Plast Reconstr Surg (2016) 2.05
Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole. Infect Immun (2008) 2.05
Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas. Int J Urol (2012) 2.04
Patterns of second-line uterotonic use in a large sample of hospitalizations for childbirth in the United States: 2007-2011. Anesth Analg (2014) 2.04
Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg (2009) 2.04
Cortical thinning in persons at increased familial risk for major depression. Proc Natl Acad Sci U S A (2009) 2.04
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol (2005) 2.03
Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection. J Infect Dis (2010) 2.02
Identification of suitable reference genes for qPCR analysis of serum microRNA in gastric cancer patients. Dig Dis Sci (2011) 2.02
Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review. Am J Clin Nutr (2009) 2.00
A natural product that lowers cholesterol as an antagonist ligand for FXR. Science (2002) 1.99
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol Biol Cell (2002) 1.98
Association between Agent Orange exposure and nonmelanotic invasive skin cancer: a pilot study. Plast Reconstr Surg (2014) 1.97
Mmp-9 deficiency enhances collagenase-induced intracerebral hemorrhage and brain injury in mutant mice. J Cereb Blood Flow Metab (2004) 1.97
Descending command systems for the initiation of locomotion in mammals. Brain Res Rev (2007) 1.97
Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog (2009) 1.96
Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci (2007) 1.94
Hidden dynamic allostery in a PDZ domain. Proc Natl Acad Sci U S A (2009) 1.93
Trends in the use and outcomes of implantable cardioverter-defibrillators in patients undergoing dialysis in the United States. Am J Kidney Dis (2011) 1.92
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature (2008) 1.91