Entry inhibitors: New advances in HCV treatment.

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Published in Emerg Microbes Infect on January 06, 2016

Authors

Xi-Jing Qian1, Yong-Zhe Zhu1, Ping Zhao1, Zhong-Tian Qi1

Author Affiliations

1: Shanghai Key Laboratory of Medical Biodefense, Department of Microbiology, Second Military Medical University, Shanghai 200433, China.

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Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56

Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A (2005) 14.78

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature (2007) 9.52

The global burden of hepatitis C. Liver Int (2009) 8.89

Viral membrane fusion. Nat Struct Mol Biol (2008) 8.54

Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci U S A (2003) 8.21

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature (2009) 8.05

Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol (1998) 7.78

Epidemiology of hepatitis C virus infection. World J Gastroenterol (2007) 7.36

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov (2006) 6.88

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med (2011) 6.21

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science (2004) 6.19

Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N Engl J Med (2013) 6.08

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Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med (2012) 3.89

Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol (2006) 3.75

Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry. J Virol (2006) 3.71

Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet (2013) 3.40

Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature (2013) 3.39

The tetraspanin web modulates immune-signalling complexes. Nat Rev Immunol (2005) 3.35

Tetraspanins. Cell Mol Life Sci (2001) 3.33

Hepatitis C virus entry depends on clathrin-mediated endocytosis. J Virol (2006) 3.33

Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial. Lancet Infect Dis (2013) 3.30

A genetically humanized mouse model for hepatitis C virus infection. Nature (2011) 3.15

Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs. Hepatology (2009) 3.10

Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate. J Biol Chem (2003) 2.94

Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus. Hepatology (2005) 2.93

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection. Sci Transl Med (2015) 2.92

Collections and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol (2001) 2.90

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Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I. J Virol (2006) 2.65

TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol (1990) 2.60

An interplay between hypervariable region 1 of the hepatitis C virus E2 glycoprotein, the scavenger receptor BI, and high-density lipoprotein promotes both enhancement of infection and protection against neutralizing antibodies. J Virol (2005) 2.52

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Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. Hepatology (2007) 2.25

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Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-claudin-1 associations. Hepatology (2010) 1.87

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Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. J Virol (2010) 1.67

Claudin association with CD81 defines hepatitis C virus entry. J Biol Chem (2010) 1.67

CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry. J Virol (2008) 1.62

Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes. Gastroenterology (2010) 1.58

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Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport. Annu Rev Physiol (2011) 1.28

Role of low-density lipoprotein receptor in the hepatitis C virus life cycle. Hepatology (2012) 1.26

New horizons in hepatitis C antiviral therapy with direct-acting antivirals. Hepatology (2013) 1.26

Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses. Proc Natl Acad Sci U S A (2010) 1.25

Lactoferrin a multiple bioactive protein: an overview. Biochim Biophys Acta (2011) 1.21

hepatitis c Virus p7 is critical for capsid assembly and envelopment. PLoS Pathog (2013) 1.20

Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem (2008) 1.18

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Hepatitis C virus p7-a viroporin crucial for virus assembly and an emerging target for antiviral therapy. Viruses (2010) 0.93

Ombitasvir/paritaprevir/ritonavir and dasabuvir tablets for hepatitis C virus genotype 1 infection. Ann Pharmacother (2015) 0.92

Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir: A Review in Chronic HCV Genotype 1 Infection. Drugs (2015) 0.91

Host-targeting agents in the treatment of hepatitis C: a beginning and an end? Antiviral Res (2013) 0.91

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Human serum amyloid A protein inhibits hepatitis C virus entry into cells. J Virol (2007) 0.90

Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes. Antimicrob Agents Chemother (2013) 0.90

Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouse. DNA Cell Biol (2006) 0.90

Ledipasvir/Sofosbuvir: a review of its use in chronic hepatitis C. Drugs (2015) 0.90

Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions. J Med Virol (2011) 0.89