Published in Int Immunol on January 07, 2016
Piperine Suppresses Pyroptosis and Interleukin-1β Release upon ATP Triggering and Bacterial Infection. Front Pharmacol (2016) 0.75
Pyroptosis of Salmonella Typhimurium-infected macrophages was suppressed and elimination of intracellular bacteria from macrophages was promoted by blocking QseC. Sci Rep (2016) 0.75
Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide. Int J Mol Med (2017) 0.75
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell (1995) 9.11
Pyroptosis: host cell death and inflammation. Nat Rev Microbiol (2009) 7.63
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol (2006) 4.82
The pathogenesis of sepsis. Ann Intern Med (1991) 4.34
Regulation of inflammasome signaling. Nat Immunol (2012) 4.10
The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol (2000) 4.10
Cecal ligation and puncture. Shock (2005) 3.93
Caspase-1-induced pyroptotic cell death. Immunol Rev (2011) 3.47
The inflammasomes: mechanisms of activation and function. Curr Opin Immunol (2010) 3.41
LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta (2006) 3.05
Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol (2010) 2.88
Molecular mechanisms of endotoxin tolerance. J Endotoxin Res (2004) 2.60
The search for effective therapy for sepsis: back to the drawing board? JAMA (2011) 2.46
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol (2014) 1.98
Sepsis. Am J Med (2007) 1.93
Molecular biology of inflammation and sepsis: a primer. Crit Care Med (2009) 1.86
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med (2006) 1.73
Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock. Am J Respir Crit Care Med (2014) 1.68
The activity of tissue factor pathway inhibitor in experimental models of superantigen-induced shock and polymicrobial intra-abdominal sepsis. Crit Care Med (2001) 1.57
An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7. J Immunol (2006) 1.55
Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells. J Immunol (2001) 1.52
Caspase-1: is IL-1 just the tip of the ICEberg? Cell Death Dis (2012) 1.47
LL-37 protects rats against lethal sepsis caused by gram-negative bacteria. Antimicrob Agents Chemother (2006) 1.45
Neutralization of tumor necrosis factor in preclinical models of sepsis. Shock (2005) 1.45
Toll-like receptor 4 modulation as a strategy to treat sepsis. Mediators Inflamm (2010) 1.35
ATP induces the release of IL-1 from LPS-primed cells in vivo. J Immunol (1995) 1.32
Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice. Infect Immun (2001) 1.31
Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice. Am J Physiol Renal Physiol (2005) 1.26
Dysregulation of the immune response in severe sepsis. Am J Med Sci (2004) 1.17
Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin Diagn Lab Immunol (2002) 1.10
Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection. Apoptosis (2009) 1.07
Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome. PLoS One (2013) 0.97
P2X(7) receptor and macrophage function. Purinergic Signal (2009) 0.96
Extracellular ATP drives systemic inflammation, tissue damage and mortality. Cell Death Dis (2014) 0.95
Pyroptotic death storms and cytopenia. Curr Opin Immunol (2013) 0.93
Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism. PLoS One (2014) 0.90
Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells. Int Immunol (2011) 0.88
Plasma ATP is required for neutrophil activation in a mouse sepsis model. Shock (2014) 0.81
Artesunate reduces serum lipopolysaccharide in cecal ligation/puncture mice via enhanced LPS internalization by macrophages through increased mRNA expression of scavenger receptors. Int J Mol Sci (2014) 0.80