Cecal ligation and puncture.

Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med (2008) 8.79

Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc (2009) 6.71

Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med (2010) 3.02

Abandon the mouse research ship? Not just yet! Shock (2014) 2.60

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med (2010) 2.38

Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med (2008) 2.34

Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit Care Med (2009) 2.04

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. J Clin Invest (2013) 2.03

Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis. Kidney Int (2011) 1.87

Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness. J Appl Physiol (1985) (2009) 1.86

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev (2013) 1.72

Platelet glycoprotein Ib-IX as a regulator of systemic inflammation. Arterioscler Thromb Vasc Biol (2014) 1.50

Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis. Shock (2008) 1.48

Modeling sepsis in the laboratory: merging sound science with animal well-being. Comp Med (2008) 1.42

Bactericidal antibiotics temporarily increase inflammation and worsen acute kidney injury in experimental sepsis. Crit Care Med (2012) 1.33

Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB. Am J Physiol Lung Cell Mol Physiol (2010) 1.27

Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice. Am J Physiol Renal Physiol (2008) 1.17

Sepsis chronically in MARS: systemic cytokine responses are always mixed regardless of the outcome, magnitude, or phase of sepsis. J Immunol (2012) 1.16

Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm. J Exp Med (2010) 1.12

Targeted delivery of siRNA to cell death proteins in sepsis. Shock (2009) 1.12

Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1. Am J Pathol (2008) 1.11

Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats. Am J Physiol Heart Circ Physiol (2009) 1.07

The outcome of polymicrobial sepsis is independent of T and B cells. Shock (2011) 1.05

A robust scoring system to evaluate sepsis severity in an animal model. BMC Res Notes (2014) 1.03

Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function. Nucleic Acids Res (2011) 1.02

Cecal ligation and puncture. Curr Protoc Immunol (2010) 1.01

Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis. Crit Care (2013) 1.00

Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury. Crit Care (2010) 1.00

Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock (2012) 0.99

Mouse eosinophils possess potent antibacterial properties in vivo. Infect Immun (2009) 0.99

Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice. Pflugers Arch (2008) 0.98

The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. J Immunol (2011) 0.98

Aging and animal models of systemic insult: trauma, burn, and sepsis. Shock (2009) 0.96

Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis. J Infect Dis (2008) 0.95

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS One (2016) 0.94

Effects of buprenorphine on a cecal ligation and puncture model in C57BL/6 mice. J Am Assoc Lab Anim Sci (2012) 0.94

Sepsis-induced acute lung injury (ALI) is milder in diabetic rats and correlates with impaired NFkB activation. PLoS One (2012) 0.94

Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis. Cytokine (2009) 0.93

Sepsis in old age: review of human and animal studies. Aging Dis (2014) 0.93

Noninvasive model of sciatic nerve conduction in healthy and septic mice: reliability and normative data. Muscle Nerve (2009) 0.92

The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol (2012) 0.92

Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1. Mediators Inflamm (2013) 0.92

Cardiac effects of induction agents in the septic rat heart. Crit Care (2009) 0.92

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis. Blood (2012) 0.91

Role of surfactant proteins A and D in sepsis-induced acute kidney injury. Shock (2015) 0.91

Shedding of tumor necrosis factor receptor 1 induced by protein A decreases tumor necrosis factor alpha availability and inflammation during systemic Staphylococcus aureus infection. Infect Immun (2013) 0.90

G-protein-coupled receptor 30 mediates estrogen's nongenomic effects after hemorrhagic shock and trauma. Am J Pathol (2007) 0.90

Cultured alveolar epithelial cells from septic rats mimic in vivo septic lung. PLoS One (2010) 0.89

It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis. Evid Based Complement Alternat Med (2012) 0.89

A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury. PLoS One (2009) 0.89

Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis. Crit Care (2009) 0.89

Use of Biotelemetry to Define Physiology-Based Deterioration Thresholds in a Murine Cecal Ligation and Puncture Model of Sepsis. Crit Care Med (2016) 0.88

Activation of common antiviral pathways can potentiate inflammatory responses to septic shock. Shock (2006) 0.88

Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response. Shock (2010) 0.88

Ensemble models of neutrophil trafficking in severe sepsis. PLoS Comput Biol (2012) 0.87

Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo. Innate Immun (2009) 0.87

T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis. PLoS One (2014) 0.87

Bioluminescence imaging of NADPH oxidase activity in different animal models. J Vis Exp (2012) 0.86

Blockade of CD137 signaling counteracts polymicrobial sepsis induced by cecal ligation and puncture. Infect Immun (2009) 0.86

CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis. J Immunol (2012) 0.86

Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins. Mol Biol Cell (2015) 0.86

Comparison of sepsis-induced transcriptomic changes in a murine model to clinical blood samples identifies common response patterns. Front Microbiol (2012) 0.85

Long-term dynamic profiling of inflammatory mediators in double-hit burn and sepsis animal models. Cytokine (2012) 0.85

Dysregulation of intracellular calcium transporters in animal models of sepsis-induced cardiomyopathy. Shock (2015) 0.85

Regulatory T cells are protective in systemic inflammation response syndrome induced by zymosan in mice. PLoS One (2013) 0.84

Gene dosage-dependent negative regulatory role of β-arrestin-2 in polymicrobial infection-induced inflammation. Infect Immun (2013) 0.84

Low-dose corticosteroid treatment and mortality in refractory abdominal septic shock after emergency laparotomy. Ann Intensive Care (2015) 0.84

Repair of damaged intestinal mucosa in a mouse model of sepsis. World J Emerg Med (2013) 0.83

Scavenger receptor-A (CD204): a two-edged sword in health and disease. Crit Rev Immunol (2014) 0.83

Electrical vagus nerve stimulation and nicotine effects in peritonitis-induced acute lung injury in rats. Inflammation (2011) 0.83

G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice. J Innate Immun (2013) 0.83

Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice. Shock (2012) 0.83

A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis. PLoS One (2014) 0.83

Characterization and pharmacological properties of a novel multifunctional Kunitz inhibitor from Erythrina velutina seeds. PLoS One (2013) 0.82

Experimentally approaching the ICU: monitoring outcome-based responses in the two-hit mouse model of posttraumatic sepsis. J Biomed Biotechnol (2011) 0.82

Use of animal model of sepsis to evaluate novel herbal therapies. J Vis Exp (2012) 0.81

Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis. Shock (2014) 0.81

Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice. Int Immunol (2016) 0.80

Elevated expression of IL-23/IL-17 pathway-related mediators correlates with exacerbation of pulmonary inflammation during polymicrobial sepsis. Shock (2014) 0.80

Role of myeloid-specific G-protein coupled receptor kinase-2 in sepsis. Int J Clin Exp Med (2011) 0.80

Changes in CRH and ACTH synthesis during experimental and human septic shock. PLoS One (2011) 0.80

Levosimendan attenuates multiple organ injury and improves survival in peritonitis-induced septic shock: studies in a rat model. Crit Care (2014) 0.80

Peritoneal wash contents used to predict mortality in a murine sepsis model. J Surg Res (2015) 0.80

Delayed Treatment with Sodium Hydrosulfide Improves Regional Blood Flow and Alleviates Cecal Ligation and Puncture (CLP)-Induced Septic Shock. Shock (2016) 0.79

NKT cells in sepsis. Clin Dev Immunol (2010) 0.79

Sepsis attenuates the anabolic response to skeletal muscle contraction. Shock (2015) 0.79

Gu-4 suppresses affinity and avidity modulation of CD11b and improves the outcome of mice with endotoxemia and sepsis. PLoS One (2012) 0.79

Intravenous Immunoglobulin with Enhanced Polyspecificity Improves Survival in Experimental Sepsis and Aseptic Systemic Inflammatory Response Syndromes. Mol Med (2015) 0.78

A dual-role of Gu-4 in suppressing HMGB1 secretion and blocking HMGB1 pro-inflammatory activity during inflammation. PLoS One (2014) 0.78

Nonhematopoietic Peroxisome Proliferator-Activated Receptor-α Protects Against Cardiac Injury and Enhances Survival in Experimental Polymicrobial Sepsis. Crit Care Med (2016) 0.78

Sequestering HMGB1 via DNA-conjugated beads ameliorates murine colitis. PLoS One (2014) 0.78

Hepatic microcirculation in murine sepsis: role of lymphocytes. Pediatr Surg Int (2008) 0.78

Febrile response induced by cecal ligation and puncture (CLP) in rats: involvement of prostaglandin E2 and cytokines. Med Microbiol Immunol (2011) 0.78

A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction. J Leukoc Biol (2016) 0.77

Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone. PLoS One (2012) 0.77

Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide. EMBO Mol Med (2015) 0.77

Low-dose cyclophosphamide improves survival in a murine treatment model of sepsis. Shock (2015) 0.77

Sepsis induced by cecal ligation and puncture. Methods Mol Biol (2013) 0.77

Probiotics improve survival of septic rats by suppressing conditioned pathogens in ascites. World J Gastroenterol (2013) 0.77

Intestinal alkaline phosphatase inhibits the translocation of bacteria of gut-origin in mice with peritonitis: mechanism of action. PLoS One (2015) 0.77

Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol (2002) 6.51

Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol (2002) 3.65

The prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. Ann Surg Oncol (2003) 3.02

Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet (2002) 2.83

Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual. Surg Clin North Am (2003) 2.82

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood (2005) 2.76

Abandon the mouse research ship? Not just yet! Shock (2014) 2.60

Identifying risk for massive transfusion in the relatively normotensive patient: utility of the prehospital shock index. J Trauma (2011) 2.59

Acute coagulopathy of trauma in the rat. Shock (2013) 2.08

Age of transfused blood: an independent predictor of mortality despite universal leukoreduction. J Trauma (2008) 2.07

The relationship of blood product ratio to mortality: survival benefit or survival bias? J Trauma (2009) 2.03

Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer. Clin Cancer Res (2004) 2.02

Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial. JAMA (2010) 2.00

Improving the ability to predict mortality among burn patients. Burns (2007) 1.79

Association between side air bags and risk of injury in motor vehicle collisions with near-side impact. J Trauma (2003) 1.77

Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Shock (2013) 1.74

Transfusions in the less severely injured: does age of transfused blood affect outcomes? J Trauma (2008) 1.73

Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1. Am J Physiol Regul Integr Comp Physiol (2008) 1.61

Hypertonic resuscitation: design and implementation of a prehospital intervention trial. J Am Coll Surg (2007) 1.61

Administration of human inter-alpha-inhibitors maintains hemodynamic stability and improves survival during sepsis. Crit Care Med (2002) 1.60

Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: report of the PULSE Trauma Work Group. Acad Emerg Med (2002) 1.57

Preliminary experience with social media for community consultation and public disclosure in exception from informed consent trials. Circulation (2013) 1.57

Influence of sex and age on mods and cytokines after multiple injuries. Shock (2007) 1.56

Duration of red cell storage influences mortality after trauma. J Trauma (2010) 1.54

High-frequency percussive ventilation and low tidal volume ventilation in burns: a randomized controlled trial. Crit Care Med (2010) 1.53

Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation. Crit Care Med (2009) 1.52

Bench-to-bedside review: latest results in hemorrhagic shock. Crit Care (2008) 1.47

Variation in the type, rate, and selection of patients for out-of-hospital airway procedures among injured children and adults. Acad Emerg Med (2009) 1.46

Knowledge, beliefs, and practices concerning seat belt use during pregnancy. J Trauma (2004) 1.41

Detection of human cytomegalovirus in normal and neoplastic breast epithelium. Herpesviridae (2010) 1.40

Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiol Genomics (2005) 1.40

Effect of chest compressions on ventricular activation. Am J Cardiol (2011) 1.40

Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J Leukoc Biol (2003) 1.39

Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis. Ann Surg (2002) 1.39

Factors associated with local recurrence after skin-sparing mastectomy and immediate breast reconstruction for invasive breast cancer. Ann Surg (2002) 1.38

Lactate is a better predictor than systolic blood pressure for determining blood requirement and mortality: could prehospital measures improve trauma triage? J Am Coll Surg (2010) 1.36

Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling. Am J Physiol Heart Circ Physiol (2008) 1.35

Gender differences in acute response to trauma-hemorrhage. Shock (2005) 1.34

Preexisting conditions and mortality in older trauma patients. J Trauma (2004) 1.33

Age-related gender differential in outcome after blunt or penetrating trauma. Shock (2003) 1.31

Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiol Genomics (2007) 1.30

Gender and susceptibility to sepsis following trauma. Endocr Metab Immune Disord Drug Targets (2006) 1.28

TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol (2007) 1.28

Treatment trends in early-stage invasive lobular carcinoma: a report from the National Cancer Data Base. Ann Surg (2005) 1.28

Preoperative radiation therapy with selective dose escalation to the margin at risk for retroperitoneal sarcoma. Cancer (2006) 1.27

The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage. J Cell Physiol (2007) 1.23

Sex differences in mortality after burn injury: results of analysis of the National Burn Repository of the American Burn Association. J Burn Care Res (2006) 1.23

Kupffer cells and their mediators: the culprits in producing distant organ damage after trauma-hemorrhage. Am J Pathol (2006) 1.22

Novel approach to prevent the transition from the hyperdynamic phase to the hypodynamic phase of sepsis: role of adrenomedullin and adrenomedullin binding protein-1. Ann Surg (2002) 1.22

Gender differences in mortality following burn injury. Shock (2002) 1.19

Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers. Carcinogenesis (2005) 1.19

The role of estrogen and receptor agonists in maintaining organ function after trauma-hemorrhage. Shock (2009) 1.19

Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injury. Cell Immunol (2002) 1.18

When apoptosis meets autophagy: deciding cell fate after trauma and sepsis. Trends Mol Med (2009) 1.17

The role of gammadelta T cells in the regulation of neutrophil-mediated tissue damage after thermal injury. J Leukoc Biol (2004) 1.17

Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats. Diabetes (2003) 1.17

Trauma and immune response--effect of gender differences. Injury (2007) 1.17

Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injury. Shock (2008) 1.17

The role of MIP-1 alpha in the development of systemic inflammatory response and organ injury following trauma hemorrhage. J Immunol (2008) 1.17

Transfusion and pneumonia in the trauma intensive care unit: an examination of the temporal relationship. J Trauma (2009) 1.16

Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage. J Leukoc Biol (2006) 1.16

G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage. Am J Pathol (2007) 1.16

Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice. J Immunol (2006) 1.15

Stress-induced hyperglycemia, not diabetic hyperglycemia, is associated with higher mortality in trauma. Ann Surg (2012) 1.14

Hemorrhage induces the rapid development of hepatic insulin resistance. Am J Physiol Gastrointest Liver Physiol (2002) 1.13

Traumatic brain injury is associated with the development of deep vein thrombosis independent of pharmacological prophylaxis. J Trauma (2009) 1.13

Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats. Am J Physiol Lung Cell Mol Physiol (2007) 1.13