Published in PLoS Comput Biol on January 11, 2016
Metabolic Regulation of the Immune Humoral Response. Immunity (2017) 0.75
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Metabolic stability and epigenesis in randomly constructed genetic nets. J Theor Biol (1969) 13.14
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72
Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science (1997) 6.58
IRF4 addiction in multiple myeloma. Nature (2008) 6.27
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity (2002) 6.27
Germinal centers. Annu Rev Immunol (2012) 6.26
Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity (2003) 5.95
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol (2006) 5.70
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet (1997) 5.55
BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity (2000) 5.36
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med (2010) 4.65
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science (1997) 4.23
B lymphocytes: how they develop and function. Blood (2008) 4.07
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol (2005) 4.04
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell (1994) 3.91
Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett (2005) 3.90
A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell (2007) 3.81
Generation of memory B cells and plasma cells in vitro. Science (1995) 3.45
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity (2006) 3.41
Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell (2005) 3.39
Pax5: the guardian of B cell identity and function. Nat Immunol (2007) 3.15
A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood (2000) 3.13
Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science (1997) 2.93
Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J Immunol (2004) 2.90
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89
Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med (2004) 2.76
The molecular and mathematical basis of Waddington's epigenetic landscape: a framework for post-Darwinian biology? Bioessays (2011) 2.68
Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity (2006) 2.64
Pathogenesis of human B cell lymphomas. Annu Rev Immunol (2012) 2.44
Lymphoid malignancies: the dark side of B-cell differentiation. Nat Rev Immunol (2002) 2.37
Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity (1999) 2.35
Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol Cell Biol (2002) 2.24
Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev (1998) 2.23
Logic-based models for the analysis of cell signaling networks. Biochemistry (2010) 2.21
Disruption of the Bcl6 gene results in an impaired germinal center formation. J Exp Med (1997) 2.17
A method for the generation of standardized qualitative dynamical systems of regulatory networks. Theor Biol Med Model (2006) 2.14
Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood (2002) 2.13
The transcriptional programme of antibody class switching involves the repressor Bach2. Nature (2004) 2.09
Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity (2007) 2.06
The balance between Pax5 and Id2 activities is the key to AID gene expression. J Exp Med (2003) 1.96
Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity (2002) 1.94
Boolean modeling in systems biology: an overview of methodology and applications. Phys Biol (2012) 1.88
Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6. J Exp Med (2000) 1.87
Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med (2005) 1.86
Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol (2006) 1.81
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol (2004) 1.79
Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity (2001) 1.78
BoolNet--an R package for generation, reconstruction and analysis of Boolean networks. Bioinformatics (2010) 1.77
BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells. Nat Immunol (2000) 1.76
Loss of Pax5 promotes plasma cell differentiation. Immunity (2006) 1.76
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J Exp Med (2009) 1.71
Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Immunity (2009) 1.67
The genetic network controlling plasma cell differentiation. Semin Immunol (2011) 1.66
Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. Blood (2009) 1.64
The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci U S A (2004) 1.63
Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch. EMBO J (2010) 1.62
Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance. J Immunol (2006) 1.62
STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Nat Immunol (2005) 1.57
Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation. Eur J Immunol (2011) 1.53
Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity (2013) 1.52
Pillars article: Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. 1994. J Immunol (2010) 1.51
Human peripheral blood B-cell compartments: a crossroad in B-cell traffic. Cytometry B Clin Cytom (2010) 1.48
Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem (2006) 1.44
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nat Immunol (2009) 1.41
Repression of BCL-6 is required for the formation of human memory B cells in vitro. J Exp Med (2007) 1.41
In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo. Nat Commun (2011) 1.41
The Cell Collective: toward an open and collaborative approach to systems biology. BMC Syst Biol (2012) 1.33
Network modeling of signal transduction: establishing the global view. Bioessays (2008) 1.31
Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. Nat Immunol (2013) 1.30
Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J Exp Med (1999) 1.29
PRDM1/Blimp-1 is expressed in human B-lymphocytes committed to the plasma cell lineage. J Pathol (2005) 1.27
Memory B cells. Nat Rev Immunol (2015) 1.27
Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol (2004) 1.24
Terminal differentiation of lymphocytes depends on Blimp-1. Curr Opin Immunol (2007) 1.24
The germinal center reaction. J Allergy Clin Immunol (2010) 1.20
An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Mol Syst Biol (2011) 1.17
Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype. J Immunol (1997) 1.07
IL-21 receptor is critical for the development of memory B cell responses. J Immunol (2010) 1.05
Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage. Front Immunol (2014) 1.05
Interleukin-5 regulates genes involved in B-cell terminal maturation. Immunology (2006) 1.03
The Arabidopsis thaliana flower organ specification gene regulatory network determines a robust differentiation process. J Theor Biol (2010) 1.00
ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation. Sci Signal (2011) 0.99
A robust model to describe the differentiation of T-helper cells. Theory Biosci (2010) 0.99
Multiparametric flow cytometry for identification and fluorescence activated cell sorting of five distinct B-cell subpopulations in normal tonsil tissue. Am J Clin Pathol (2011) 0.98
IRF4 negatively regulates proliferation of germinal center B cell-derived Burkitt's lymphoma cell lines and induces differentiation toward plasma cells. Eur J Cell Biol (2007) 0.97
BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells. Proc Natl Acad Sci U S A (2010) 0.96
Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright. EMBO J (2009) 0.96
A mathematical model for the germinal center morphology and affinity maturation. J Theor Biol (2002) 0.96
IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts. Blood (2013) 0.93
Growth factor requirements for the stimulation of germinal center B cells: evidence for an IL-2-dependent pathway of development. Int Immunol (1991) 0.93
Human BSAP and BLIMP1 conform an autoregulatory feedback loop. Blood (2007) 0.92
Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus. Oncogene (2013) 0.92
Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation. Semin Immunol (1998) 0.90
A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci (2010) 0.88
The regulatory network that controls the differentiation of T lymphocytes. Biosystems (2013) 0.87
Chemotaxis in densely populated tissue determines germinal center anatomy and cell motility: a new paradigm for the development of complex tissues. PLoS One (2011) 0.86
Boolean modeling: a logic-based dynamic approach for understanding signaling and regulatory networks and for making useful predictions. Wiley Interdiscip Rev Syst Biol Med (2014) 0.85
Building Qualitative Models of Plant Regulatory Networks with SQUAD. Front Plant Sci (2012) 0.83