Published in J Exp Med on October 27, 2003
Mechanism and regulation of class switch recombination. Annu Rev Immunol (2008) 5.98
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59
Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med (2004) 2.76
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell (2009) 2.42
Estrogen directly activates AID transcription and function. J Exp Med (2009) 2.37
Unique maturation program of the IgE response in vivo. Immunity (2007) 2.15
Inducible DNA breaks in Ig S regions are dependent on AID and UNG. J Exp Med (2005) 1.99
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A (2006) 1.95
Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med (2008) 1.78
AID and somatic hypermutation. Adv Immunol (2010) 1.74
A coming-of-age story: activation-induced cytidine deaminase turns 10. Nat Immunol (2009) 1.68
The IRF family, revisited. Biochimie (2007) 1.64
Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch. EMBO J (2010) 1.62
Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells. J Exp Med (2007) 1.47
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nat Immunol (2009) 1.41
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat Immunol (2009) 1.41
APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells. Sci Rep (2012) 1.40
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci U S A (2005) 1.40
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination. Crit Rev Immunol (2007) 1.19
Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair. Adv Immunol (2014) 1.11
Affinity of antigen encounter and other early B-cell signals determine B-cell fate. Curr Opin Immunol (2007) 1.11
Differential requirement for OBF-1 during antibody-secreting cell differentiation. J Exp Med (2005) 1.10
Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma. Am J Pathol (2006) 1.08
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. J Exp Med (2007) 1.06
Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development. Blood (2010) 1.00
Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes. Immunology (2009) 0.98
Regulation of Id2 expression by CCAAT/enhancer binding protein beta. Nucleic Acids Res (2005) 0.95
Augmentation of antibody responses by retinoic acid and costimulatory molecules. Semin Immunol (2008) 0.94
E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol (2009) 0.92
Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res (2012) 0.92
Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci U S A (2013) 0.90
Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment. PLoS One (2009) 0.90
AID/APOBEC deaminases and cancer. Oncoscience (2015) 0.89
Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications. Semin Immunol (2012) 0.89
Alum Directly Modulates Murine B Lymphocytes to Produce IgG1 Isotype. Immune Netw (2013) 0.89
Activation-induced cytidine deaminase (AID)-associated multigene signature to assess impact of AID in etiology of diseases with inflammatory component. PLoS One (2011) 0.87
A critical role of the Thy28-MYH9 axis in B cell-specific expression of the Pax5 gene in chicken B cells. PLoS One (2015) 0.87
B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins. Proc Natl Acad Sci U S A (2008) 0.86
Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers. Immune Netw (2012) 0.85
MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals. J Immunol (2015) 0.84
Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues. Aging Dis (2011) 0.84
APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells. Cytokine (2012) 0.84
Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion. Mol Immunol (2007) 0.83
Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity. Nat Rev Immunol (2016) 0.82
In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression. PLoS One (2013) 0.82
Mitochondrial function provides instructive signals for activation-induced B-cell fates. Nat Commun (2015) 0.81
Walking the AID tightrope. Nat Immunol (2010) 0.81
Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response. Front Immunol (2015) 0.80
Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase? J Exp Med (2009) 0.80
A novel pax5-binding regulatory element in the igκ locus. Front Immunol (2014) 0.79
Aberrant expression of ID2 protein and its correlation with EBV-LMP1 and P16(INK4A) in classical Hodgkin lymphoma in China. BMC Cancer (2008) 0.77
Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development. J Exp Med (2016) 0.76
A Network Model to Describe the Terminal Differentiation of B Cells. PLoS Comput Biol (2016) 0.75
Activation of Aicda gene transcription by Pax5 in plasmacytoma cells. Immunol Res (2013) 0.75
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol (2000) 8.89
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther (1996) 7.12
Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods (1997) 7.08
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem (1999) 6.67
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity (2002) 6.27
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell (1994) 5.41
The helix-loop-helix gene E2A is required for B cell formation. Cell (1994) 4.59
Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu Rev Immunol (2001) 4.03
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell (1994) 3.91
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J (1999) 3.14
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science (2002) 3.09
E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat Immunol (2003) 3.03
Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol (1998) 2.64
Constitutive expression of the Id1 gene impairs mouse B cell development. Cell (1994) 2.63
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature (2002) 2.35
The AID enzyme induces class switch recombination in fibroblasts. Nature (2002) 2.28
Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol Cell Biol (2002) 2.24
E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J (1999) 1.93
Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity (2001) 1.78
Essential role of Id2 in negative regulation of IgE class switching. Nat Immunol (2002) 1.71
Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity (2002) 1.70
Role of Id family proteins in growth control. J Cell Physiol (2002) 1.65
Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms. J Biol Chem (2001) 1.43
Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J (1999) 1.37
Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity (1999) 1.35
The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes. Mol Cell Biol (1999) 1.14
Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. Mol Cell Biol (2001) 1.13
TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice. J Allergy Clin Immunol (2003) 1.09
Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching. Eur J Immunol (2001) 0.94
OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity. J Biol Chem (2000) 0.93
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line. J Immunol (1998) 0.90
Dissociation of Pax-5 from KI and KII sites during kappa-chain gene rearrangement correlates with its association with the underphosphorylated form of retinoblastoma. J Immunol (2001) 0.87
Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase. Nucleic Acids Res (1998) 0.86
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol (2008) 5.10
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med (2004) 3.58
Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J Exp Med (2007) 3.36
E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat Immunol (2003) 3.03
Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood (2006) 2.94
Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med (2004) 2.91
Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol (2003) 2.91
Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A (2004) 2.75
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity (2008) 2.57
Transcription-coupled events associating with immunoglobulin switch region chromatin. Science (2003) 2.50
Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection. Hum Pathol (2012) 2.16
The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity (2012) 2.15
A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell (2007) 2.12
Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas. Cancer Res (2006) 2.03
A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. Int Immunol (2004) 2.02
Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol (2012) 1.95
Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol (2008) 1.92
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol (2004) 1.85
UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. Int J Clin Oncol (2009) 1.82
The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway. Mol Cell Biol (2009) 1.71
Essential role of Id2 in negative regulation of IgE class switching. Nat Immunol (2002) 1.71
Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells. Immunity (2002) 1.70
ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Am J Physiol Renal Physiol (2010) 1.69
Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol (2006) 1.67
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood (2012) 1.63
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol (2007) 1.63
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood (2008) 1.60
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J (2009) 1.58
Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid. J Clin Invest (2006) 1.57
alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation (2005) 1.56
Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Dev Cell (2007) 1.56
The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells. Nat Immunol (2011) 1.54
Isolation and species distribution of staphylococci from animal and human skin. J Vet Med Sci (2002) 1.52
Renoprotective effect of erythropoietin against ischaemia-reperfusion injury in a non-human primate model. Nephrol Dial Transplant (2010) 1.52
Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Mol Cell Biol (2005) 1.50
Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J Clin Endocrinol Metab (2005) 1.48
Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation (2003) 1.47
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Blood (2005) 1.38
Two distinct types of Langerhans cells populate the skin during steady state and inflammation. Immunity (2012) 1.36
Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma. Cancer Res (2002) 1.36
Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol (2002) 1.35
Impaired IgG production in mice deficient for heat shock transcription factor 1. J Biol Chem (2004) 1.29
Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol (2004) 1.29
Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. Nucleic Acids Res (2006) 1.26
Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation (2004) 1.26
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest (2005) 1.24
Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins. Blood (2008) 1.24
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. J Immunol (2010) 1.22
Method for hemoglobin A(1c) measurement based on peptide analysis by electrospray ionization mass spectrometry with deuterium-labeled synthetic peptides as internal standards. Clin Chem (2003) 1.21
Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010. Clin Exp Nephrol (2013) 1.17
Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine. Blood (2007) 1.14
Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus. Nat Commun (2012) 1.11
Injury and progressive loss of peritubular capillaries in the development of chronic allograft nephropathy. Kidney Int (2005) 1.10
TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice. J Allergy Clin Immunol (2003) 1.09
Comparison of the indocyanine green fluorescence and blue dye methods in detection of sentinel lymph nodes in early-stage breast cancer. Ann Surg Oncol (2013) 1.09
Case of subcutaneous sparganosis: use of imaging in definitive preoperative diagnosis. J Dermatol (2007) 1.09
Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling. J Immunol (2010) 1.08
Catalogue of soluble proteins in the human vitreous humor: comparison between diabetic retinopathy and macular hole. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 1.07
Effects of repeated subculturing and prolonged storage at room temperature of enterohemorrhagic Escherichia coli O157:H7 on pulsed-field gel electrophoresis profiles. J Clin Microbiol (2002) 1.06
Pig islet xenograft rejection in a mouse model with an established human immune system. Xenotransplantation (2008) 1.04
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med (2009) 1.04
Genetic and biochemical properties of streptococcal NAD-glycohydrolase inhibitor. J Biol Chem (2005) 1.03
Nucleo-cytoplasmic shuttling of Id2, a negative regulator of basic helix-loop-helix transcription factors. J Biol Chem (2004) 1.03
Neural substrates of human facial expression of pleasant emotion induced by comic films: a PET Study. Neuroimage (2002) 1.02
Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety. J Transl Med (2011) 1.02
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. Proc Natl Acad Sci U S A (2012) 1.02
Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma. Cancer Lett (2008) 1.00
Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners. Blood (2009) 1.00
Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis. J Immunol (2003) 1.00
Prevalence and characterization of Staphylococcus aureus and enterotoxigenic Staphylococcus aureus in retail raw chicken meat throughout Japan. J Vet Med Sci (2005) 1.00
Identification of BMP-responsive elements in the mouse Id2 gene. Biochem Biophys Res Commun (2010) 0.99
GalT-KO pigs: is the cup half empty or half full? Transplantation (2007) 0.99
Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus. Clin Rheumatol (2009) 0.99
Statin attenuates experimental anti-glomerular basement membrane glomerulonephritis together with the augmentation of alternatively activated macrophages. Am J Pathol (2010) 0.99
Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF/KIT protein interactions and the downstream effector, MITF-M. J Pathol (2004) 0.98
Characterization of methicillin-resistant Staphylococcus aureus isolated from retail raw chicken meat in Japan. J Vet Med Sci (2005) 0.98
Surgical treatment of 144 cases of hilar cholangiocarcinoma without liver-related mortality. World J Surg (2014) 0.98
Molecular characterization of NADase-streptolysin O operon of hemolytic streptococci. Biochim Biophys Acta (2004) 0.98
Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model. J Immunol (2008) 0.97
Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy. Lab Invest (2012) 0.97
A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. Int Immunol (2006) 0.96