Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

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Published in Cell Metab on January 07, 2016

Authors

Annelies Quaegebeur1, Inmaculada Segura1, Roberta Schmieder2, Dries Verdegem3, Ilaria Decimo1, Francesco Bifari1, Tom Dresselaers4, Guy Eelen1, Debapriva Ghosh5, Shawn M Davidson6, Sandra Schoors1, Dorien Broekaert2, Bert Cruys1, Kristof Govaerts4, Carla De Legher1, Ann Bouché1, Luc Schoonjans1, Matt S Ramer7, Gene Hung8, Goele Bossaert9, Don W Cleveland10, Uwe Himmelreich4, Thomas Voets5, Robin Lemmens11, C Frank Bennett8, Wim Robberecht11, Katrien De Bock1, Mieke Dewerchin1, Bart Ghesquière12, Sarah-Maria Fendt2, Peter Carmeliet13

Author Affiliations

1: Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, Belgium.
2: Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, University of Leuven, Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Vesalius Research Center, VIB, Leuven, Belgium.
3: Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, Belgium; Metabolomics Expertise Center, Vesalius Research Center, VIB, Leuven, Belgium.
4: Biomedical MRI/Mosaic, Department of Imaging and Pathology, University of Leuven, Leuven, Belgium.
5: Laboratory of Ion Channel Research and TRP channel research platform Leuven, Department of Cellular and Molecular Medicine, University of Leuven, Leuven, Belgium.
6: Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7: Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, Belgium; International Collaboration on Repair Discoveries, the University of British Columbia, Vancouver, Canada.
8: Isis Pharmaceuticals, Carlsbad, CA 92008, USA.
9: Leuven Statistics Research Centre (LStat), University of Leuven, Leuven, Belgium.
10: Ludwig Institute for Cancer Research, Department of Medicine and Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA.
11: Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium; Experimental Neurology (Department of Neurosciences) and Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven, Leuven, Belgium; Neurology, University Hospitals Leuven, Leuven, Belgium.
12: Metabolomics Expertise Center, Vesalius Research Center, VIB, Leuven, Belgium.
13: Laboratory of Angiogenesis and Neurovascular link, Department of Oncology, University of Leuven, Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven, Belgium. Electronic address: peter.carmeliet@vib-kuleuven.be.

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