Published in Proc Natl Acad Sci U S A on June 01, 1977
Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens. Proc Natl Acad Sci U S A (1978) 2.24
A rapid banding technique for human chromosomes. Lancet (1971) 27.45
AGAR SUSPENSION CULTURE FOR THE SELECTIVE ASSAY OF CELLS TRANSFORMED BY POLYOMA VIRUS. Virology (1964) 14.14
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst (1973) 11.26
ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS. Proc Natl Acad Sci U S A (1963) 2.25
Fibrinolytic activity in a human fibrosarcoma cell line and evidence for the induction of plasminogen activator secretion during tumor formation. Cell (1975) 1.48
Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. Am J Hum Genet (1973) 1.47
Identification of the chromosomes that control malignancy. Nat New Biol (1973) 1.22
Growth and characterization of human skin epithelial cell cultures. In Vitro (1976) 1.17
Correlation between balance of specific chromosomes and expression of malignancy in hamster cells. J Natl Cancer Inst (1975) 1.05
Carcinogenesis in vitro. II. Chemical transformation of diploid human cell cultures: A rare event. In Vitro (1975) 1.00
Early changes in chromosomal number and structure after treatment of fetal hamster cultures with transforming doses of polycyclic hydrocarbons. J Natl Cancer Inst (1972) 0.91
Characterisation of human cells transformed in vitro by urethane. Nature (1975) 0.90
Reversible appearance of a specific chromosome which suppresses malignancy. Nature (1974) 0.88
A new method for covering large surface area wounds with autografts. I. In vitro multiplication of rabbit-skin epithelial cells. Arch Surg (1974) 0.87
A new method for covering large surface area wounds with autografts. II. Surgical application of tissue culture expanded rabbit-skin autografts. Arch Surg (1974) 0.86
Chromosome balance and the control of malignancy. J Cell Physiol (1976) 0.85
Hydrocarbon-metabolizing activity of various mammalian cells in culture. In Vitro (1977) 0.85
Metabolism of benzo(a)pyrene by human epithelial cells in vitro. Cancer Res (1975) 0.82
Giemsa banding in an established line of human malignant meningioma. Humangenetik (1973) 0.80
Fibroblast chromosome preparations. Lancet (1967) 0.79
Toxicity of aromatic hydrocarbons on normal human epidermal cells in vitro. Cancer Res (1971) 0.78
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature (1983) 11.57
Structural evidence for the authenticity of the human retinoblastoma gene. Science (1987) 4.67
Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D. Science (1983) 4.43
Retinoblastoma: clues to human oncogenesis. Science (1984) 3.43
Expression and amplification of the N-myc gene in primary retinoblastoma. Nature (1984) 2.99
Resolutions and identification of the core deoxynucleoproteins of the simian virus 40. Biochem Biophys Res Commun (1973) 2.90
Patient with 13 chromosome deletion: evidence that the retinoblastoma gene is a recessive cancer gene. Science (1983) 2.78
Transformation of primary rat embryo cells by adenovirus type 2. Proc Natl Acad Sci U S A (1967) 2.53
5-Bromo-2'-deoxyuridine potentiation of transformation of rat-embryo cells induced in vitro by 3-methylcholanthrene: induction of rat leukemia virus gs antigen in transformed cells. Proc Natl Acad Sci U S A (1973) 2.32
Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. Oncogene (1988) 2.29
Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. J Natl Cancer Inst (2001) 2.13
Correlation of HER-2/neu amplification with expression and with other prognostic factors in 1103 breast cancers. J Natl Cancer Inst (1992) 2.05
Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med (1994) 1.97
Replacement of bovine mitochondrial DNA by a sequence variant within one generation. Genetics (1991) 1.96
Adenovirus type 12-rat embryo transformation system. J Virol (1967) 1.67
Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines. Cancer Res (1977) 1.66
Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53. Cancer Res (1998) 1.65
Asbestos-associated chromosomal changes in human mesothelial cells. Proc Natl Acad Sci U S A (1985) 1.60
Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas. J Natl Cancer Inst (1995) 1.57
Adenoviral-mediated interferon alpha overcomes resistance to the interferon protein in various cancer types and has marked bystander effects. Cancer Gene Ther (2006) 1.56
Intimal hyperplasia after balloon injury is attenuated by blocking selectins. Circulation (1997) 1.55
Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer. J Natl Cancer Inst (1992) 1.51
Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 beta. Proc Natl Acad Sci U S A (2001) 1.50
Morphological transformation of rat embryo cells induced by diethylnitrosamine and murine leukemia viruses. J Natl Cancer Inst (1970) 1.50
Fibrinolytic activity in a human fibrosarcoma cell line and evidence for the induction of plasminogen activator secretion during tumor formation. Cell (1975) 1.48
Ureteroinguinal hernia: a rare companion of sliding inguinal hernias. Am Surg (1991) 1.48
I. In vitrol transformation of rat embryo cells: correlations with the known tumorigenic activities of chemicals in rodents. In Vitro (1975) 1.42
In vivo-like growth of human tumors in vitro. Proc Natl Acad Sci U S A (1986) 1.40
Occurrence and properties of a chromatin-associated F1-histone phosphokinase in mitotic Chinese hamster cells. Biochemistry (1972) 1.38
The retinoblastoma gene is involved in malignant progression of astrocytomas. Ann Neurol (1994) 1.37
Conditioned medium from Ad-IFN-alpha-infected bladder cancer and normal urothelial cells is cytotoxic to cancer cells but not normal cells: further evidence for a strong bystander effect. Cancer Gene Ther (2008) 1.37
Glucose challenge testing in pregnancy. Am J Obstet Gynecol (1991) 1.37
Mouse leukemia virus activation by chemical carcinogens. Science (1969) 1.36
Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors. Cancer Res (1997) 1.35
The natural history of bilateral aortofemoral bypass grafts for ischemia of the lower extremities. Arch Surg (1975) 1.35
Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma. Cancer Res (1994) 1.34
In vitro correlates of transformation in C3H/10T1/2 clone 8 mouse cells. Cancer Res (1976) 1.33
Temporal acquistion of enhanced fibrinolytic activity by syrian hamster embryo cells following treatment with benzo(a)pyrene. Cancer Res (1977) 1.31
The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells. Proc Natl Acad Sci U S A (1991) 1.29
Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker. Cancer Gene Ther (2009) 1.25
Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res (1991) 1.23
Lack of nuclear RB protein staining in G0/middle G1 cells: correlation to changes in total RB protein level. Oncogene (1991) 1.23
The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells. Oncogene (1989) 1.22
Mantle cell lymphoma: correlation of clinical outcome and biologic features with three histologic variants. J Clin Oncol (1997) 1.21
Efficacy of a single intravesical treatment with Ad-IFN/Syn 3 is dependent on dose and urine IFN concentration obtained: implications for clinical investigation. Cancer Gene Ther (2006) 1.20
Humoral defense mechanisms in cryptococcosis: substances in normal human serum, saliva, and cerebrospinal fluid affecting the growth of Cryptococcus neoformans. J Infect Dis (1966) 1.19
Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency. Cancer Res (1984) 1.19
Relationship between fibrinolysis of cultured cells and malignancy. J Natl Cancer Inst (1975) 1.18
Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RB locus. Cancer Res (1994) 1.18
Activation and isolation of hamster-specific C-type RNA viruses from tumors induced by cell cultures transformed by chemical carcinogens. Proc Natl Acad Sci U S A (1971) 1.18
Growth and characterization of human skin epithelial cell cultures. In Vitro (1976) 1.17
Induction of morphological transformation in mouse C3H/10T1/2 clone 8 cells and chromosomal damage in hamster A(T1)C1-3 cells by cancer chemotherapeutic agents. Cancer Res (1977) 1.16
Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications. Hum Pathol (1999) 1.16
Nonrandom chromosomal changes in untreated retinoblastomas. Cancer Genet Cytogenet (1983) 1.15
The effect of calcium on cell lines derived from adenovirus type 12-induced hamster tumors. Exp Cell Res (1965) 1.13
Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen. Immunogenetics (1982) 1.12
F1-histone modification at metaphase in Chinese hamster cells. Exp Cell Res (1972) 1.11
Prevalence of endogenous type-C virus in normal hamster tissues and hamster tumors induced by chemical carcinogens, simian virus 40, and polyoma virus. J Natl Cancer Inst (1974) 1.11
An improved intravesical model using human bladder cancer cell lines to optimize gene and other therapies. Cancer Gene Ther (2000) 1.11
Calcium sensitivity of cell cultures derived from adenovirus-induced tumors. Proc Soc Exp Biol Med (1966) 1.11
Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res (1983) 1.11
Inflammatory aneurysms of the abdominal aorta. Surgery (1978) 1.11
Natural history of nonstenotic, asymptomatic ulcerative lesions of the carotid artery. Arch Surg (1978) 1.11
Randomized prospective double-blind trial in healing chronic diabetic foot ulcers. CT-102 activated platelet supernatant, topical versus placebo. Diabetes Care (1992) 1.09
Purification, biochemical characterization, and biological function of human esterase D. Proc Natl Acad Sci U S A (1986) 1.09
The use of medicinal leeches in the salvage of flaps with venous congestion. Ann Plast Surg (1992) 1.08
Enhanced tumor cell growth suppression by an N-terminal truncated retinoblastoma protein. Proc Natl Acad Sci U S A (1994) 1.08
Therapeutic and economic impact of a modern amputation program. Ann Surg (1979) 1.08
Prediction of familial predisposition to retinoblastoma. N Engl J Med (1986) 1.08
Human sarcoma cells in culture. Identification by colony-forming ability on monolayers of normal cells. Exp Cell Res (1970) 1.08
Digital video subtraction angiography: screening technique for renovascular hypertension. Surgery (1981) 1.07
Extrathoracic repair of branch occlusions of the aortic arch. Am J Surg (1976) 1.07
Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression. Int J Cancer (1993) 1.06
Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression. Cancer Res (1994) 1.06
p53 and RB expression predict progression in T1 bladder cancer. Clin Cancer Res (1998) 1.06
Differential retinoblastoma and p16(INK4A) protein expression in neuroendocrine tumors of the lung. Cancer (2000) 1.06
Implication of chromosome 11 in the suppression of neoplastic expression in human cell hybrids. Cancer Res (1986) 1.06
Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti-RB antibodies. Int J Cancer (1994) 1.05
Correlation between balance of specific chromosomes and expression of malignancy in hamster cells. J Natl Cancer Inst (1975) 1.05
Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma. Cancer Res (1994) 1.05
Validation and long term performance characteristics of a quantitative enzyme linked immunosorbent assay (ELISA) for human anti-PA IgG. J Immunol Methods (2011) 1.04
Physicochemical properties of the infectious bursal agent (IBA). Avian Dis (1967) 1.03
Studies on the structure of metaphase and interphase chromatin of Chinese hamster cells by circular dichroism and thermal denaturation. Biochemistry (1972) 1.02
Prosthetic arterial graft material. Influence on neointimal healing and bacteremic infectibility. Arch Surg (1980) 1.02
Anchorage independent growth and plasminogen activator production by bovine endothelial cells. J Cell Biol (1980) 1.02
Enhanced tumor suppressor gene therapy via replication-deficient adenovirus vectors expressing an N-terminal truncated retinoblastoma protein. Cancer Res (1996) 1.02
The neurotoxicity of cyclotrimethylenetrinitramine (RDX) in a child: a clinical and pharmacokinetic evaluation. J Toxicol Clin Toxicol (1986) 1.01
Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas. Cancer Res (1991) 1.01
Recurrent cervical carcinoma after radical hysterectomy. Gynecol Oncol (1988) 1.01
Carcinogenesis in vitro. II. Chemical transformation of diploid human cell cultures: A rare event. In Vitro (1975) 1.00
Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma. J Natl Cancer Inst (1994) 1.00