Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.

Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A). J Med Chem (2017) 0.75

TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem (2010) 2.66

The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol (2008) 2.61

Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem (2009) 2.59

Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33

Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07

X-ray structure of a calcium-activated TMEM16 lipid scramblase. Nature (2014) 2.04

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98

Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol (2007) 1.85

Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J (2010) 1.78

Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology. Circ Res (2012) 1.69

Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A. J Biol Chem (2010) 1.58

Structure and function of TMEM16 proteins (anoctamins). Physiol Rev (2014) 1.56

Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci (2012) 1.55

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J (2011) 1.45

TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels. Mol Cell Proteomics (2010) 1.43

TMEM16 proteins: unknown structure and confusing functions. J Mol Biol (2014) 1.21

Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. Br J Pharmacol (2013) 1.18

Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity. J Physiol (2012) 1.17

Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol Pain (2014) 1.16

Targeting ion channels in cystic fibrosis. J Cyst Fibros (2015) 1.14

The Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis. Cancer Med (2014) 1.05

Role of anoctamins in cancer and apoptosis. Philos Trans R Soc Lond B Biol Sci (2014) 1.04

Epidermal growth factor chronically upregulates Ca(2+)-dependent Cl(-) conductance and TMEM16A expression in intestinal epithelial cells. J Physiol (2012) 0.94

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure. J Clin Invest (2014) 0.92

Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorg Med Chem (2012) 0.91

The TMEM16A chloride channel as an alternative therapeutic target in cystic fibrosis. Int J Biochem Cell Biol (2014) 0.87

Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases. Mediators Inflamm (2015) 0.87

The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney Int (2014) 0.87