Published in Philos Trans R Soc Lond B Biol Sci on February 03, 2014
Ion channels in cancer: future perspectives and clinical potential. Philos Trans R Soc Lond B Biol Sci (2014) 0.95
ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch (2014) 0.94
Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer. PLoS One (2015) 0.88
Ano1/TMEM16A Overexpression Is Associated with Good Prognosis in PR-Positive or HER2-Negative Breast Cancer Patients following Tamoxifen Treatment. PLoS One (2015) 0.80
TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-β signaling. Oncotarget (2015) 0.80
TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration. Br J Pharmacol (2014) 0.80
Modulating Ca(2+) signals: a common theme for TMEM16, Ist2, and TMC. Pflugers Arch (2015) 0.79
Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells. Pflugers Arch (2015) 0.79
Identification and characterization of ANO9 in stage II and III colorectal carcinoma. Oncotarget (2015) 0.79
Anoctamins/TMEM16 Proteins: Chloride Channels Flirting with Lipids and Extracellular Vesicles. Annu Rev Physiol (2016) 0.78
Effects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract. Br J Pharmacol (2016) 0.78
Cl(-) channels in apoptosis. Eur Biophys J (2016) 0.78
Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance. Channels (Austin) (2015) 0.78
Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin. Front Plant Sci (2015) 0.77
Clinical significance of Anoctamin-1 gene at 11q13 in the development and progression of head and neck squamous cell carcinomas. Sci Rep (2015) 0.76
Activation of K(+) channel by 1-EBIO rescues the head and neck squamous cell carcinoma cells from Ca(2+) ionophore-induced cell death. Korean J Physiol Pharmacol (2015) 0.76
Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1. J Enzyme Inhib Med Chem (2016) 0.75
How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data. N Am Actuar J (2016) 0.75
Identification of the Novel TMEM16A Inhibitor Dehydroandrographolide and Its Anticancer Activity on SW620 Cells. PLoS One (2015) 0.75
Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. PLoS One (2015) 0.75
Does Immunohistochemistry for Discovered on GIST1 and Minichromosome Maintenance Protein7 Provide Additional Clinicopathological Value in Gastrointestinal Stromal Tumors? World J Oncol (2015) 0.75
Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A). J Med Chem (2017) 0.75
Translating the histone code. Science (2001) 56.77
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science (2008) 8.74
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Histone modifications in transcriptional regulation. Curr Opin Genet Dev (2002) 8.10
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell (2008) 7.79
Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev (2008) 4.66
Calcium-dependent phospholipid scrambling by TMEM16F. Nature (2010) 3.63
Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol (2009) 3.02
Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol (2009) 2.96
Tissue microarrays for gene amplification surveys in many different tumor types. Clin Cancer Res (1999) 2.79
A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol (2008) 2.68
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. Proc Natl Acad Sci U S A (2001) 2.62
Ion channels and cancer. J Membr Biol (2005) 2.56
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell (2012) 2.24
Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res Treat (2003) 2.14
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma. Cancer Lett (2012) 2.04
An unexpected role for ion channels in brain tumor metastasis. Exp Biol Med (Maywood) (2008) 2.00
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98
TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem (2009) 1.89
Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels. Am J Physiol Cell Physiol (2009) 1.80
Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J (2010) 1.78
Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem (2013) 1.74
Targeting ion channels in cancer: a novel frontier in antineoplastic therapy. Curr Med Chem (2009) 1.70
Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display. Oncogene (2006) 1.56
Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci (2012) 1.55
Role of ion channels and transporters in cell migration. Physiol Rev (2012) 1.52
Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma. Genes Chromosomes Cancer (2006) 1.49
Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proc Natl Acad Sci U S A (2011) 1.46
Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci U S A (2012) 1.41
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int J Cancer (2004) 1.41
ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines. Br J Cancer (2010) 1.38
Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration. Am J Physiol Cell Physiol (2011) 1.37
DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol (2012) 1.34
Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol (2011) 1.32
Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn (2008) 1.30
Anoctamins. Pflugers Arch (2011) 1.29
Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. PLoS One (2012) 1.26
NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. Proc Natl Acad Sci U S A (2004) 1.25
Inhibition of cell proliferation by a selective inhibitor of the Ca(2+)-activated Cl(-) channel, Ano1. Biochem Biophys Res Commun (2012) 1.20
Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation. Circulation (2012) 1.20
Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci U S A (2012) 1.17
Forming the cell rear first: breaking cell symmetry to trigger directed cell migration. Nat Cell Biol (2010) 1.16
TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel. Am J Physiol Cell Physiol (2013) 1.16
Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice. Oncogene (2009) 1.15
Preclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinoma. Br J Cancer (2011) 1.13
Exon-based clustering of murine breast tumor transcriptomes reveals alternative exons whose expression is associated with metastasis. Cancer Res (2010) 1.12
NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. Cancer Res (2007) 1.08
Ca2+ signaling, intracellular pH and cell volume in cell proliferation. J Membr Biol (2005) 0.99
Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents. Cell Death Dis (2013) 0.99
Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells. J Biol Chem (2008) 0.96
Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells. J Am Soc Nephrol (2009) 0.92
Glioma-associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with radiation therapy (RTOG 9003). J Clin Oncol (2011) 0.92
Expression and functional significance of the Ca(2+)-activated Cl(-) channel ANO6 in dendritic cells. Cell Physiol Biochem (2012) 0.92
Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit. Gastroenterology (2012) 0.89
DNA amplifications in breast cancer: genotypic-phenotypic correlations. Future Oncol (2010) 0.89
Pancreatic expression of DOG1: a novel gastrointestinal stromal tumor (GIST) biomarker. Appl Immunohistochem Mol Morphol (2009) 0.88
Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns (2007) 0.88
Streptomycin and its analogues are potent inhibitors of the hypotonicity-induced Ca2+ entry and Cl- channel activity. FEBS Lett (2003) 0.84
Targeted expression of anoctamin calcium-activated chloride channels in rod photoreceptor terminals of the rodent retina. Invest Ophthalmol Vis Sci (2013) 0.83
Plasma thyronine levels in carcinoma of the breast and colon. Arch Intern Med (1981) 0.79
Volume-sensitive organic osmolyte/anion channels in cancer: novel approaches to studying channel modulation employing proteomics technologies. Ann N Y Acad Sci (2004) 0.78
Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol (2008) 2.39
First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov (2012) 2.31
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov (2013) 2.29
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A (2006) 2.16
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98
Expression and function of epithelial anoctamins. J Biol Chem (2010) 1.95
Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol (2008) 1.95
TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem (2009) 1.89
Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J (2010) 1.78
Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation (2006) 1.64
Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci (2012) 1.55
Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis. Trends Pharmacol Sci (2007) 1.55
Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions. Cell Calcium (2009) 1.51
Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin? Pflugers Arch (2007) 1.47
Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proc Natl Acad Sci U S A (2011) 1.46
DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol (2012) 1.34
Bestrophin 1 and 2 are components of the Ca(2+) activated Cl(-) conductance in mouse airways. Biochim Biophys Acta (2008) 1.33
Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia. J Biol Chem (2006) 1.31
Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model. Int J Cancer (2007) 1.30
Anoctamins. Pflugers Arch (2011) 1.29
A new paradigm for the diagnosis and management of unknown primary tumors of the head and neck: a role for transoral robotic surgery. Laryngoscope (2012) 1.26
Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. PLoS One (2012) 1.26
The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon. Gastroenterology (2004) 1.25
Comparison of clinical outcomes, patient, and surgeon satisfaction following topical versus peribulbar anesthesia for phacoemulsification and intraocular lens implantation: a randomized, controlled trial. Indian J Ophthalmol (2014) 1.24
Delayed presentation of cataracts in children: are they worth operating upon? Ophthalmic Epidemiol (2010) 1.24
Mechanistic insight into control of CFTR by AMPK. J Biol Chem (2008) 1.21
Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Clin Cancer Res (2007) 1.15
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport. J Biol Chem (2010) 1.15
Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells. Biol Chem (2011) 1.12
Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer. Transpl Int (2005) 1.11
Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. J Immunol (2008) 1.10
Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels. Cell Physiol Biochem (2008) 1.10
Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia. Pediatr Res (2003) 1.09
Expression and function of epithelial anoctamins. Exp Physiol (2011) 1.06
Endoscopic endonasal resection of esthesioneuroblastoma: a multicenter study. Am J Rhinol Allergy (2009) 1.06
Comparison of endothelial cell loss after cataract surgery: phacoemulsification versus manual small-incision cataract surgery: six-week results of a randomized control trial. J Cataract Refract Surg (2010) 1.05
Voltage-gated K+ channels support proliferation of colonic carcinoma cells. FASEB J (2006) 1.04
ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel. Pflugers Arch (2009) 1.04
P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport. J Clin Invest (2003) 1.04
CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. Gastroenterology (2004) 1.04
Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea. Cell Physiol Biochem (2005) 1.03
Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy. Clin Cancer Res (2004) 1.02
CFTR and TMEM16A are separate but functionally related Cl- channels. Cell Physiol Biochem (2011) 1.02
Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase? Pflugers Arch (2013) 1.02
EGFR tyrosine kinase inhibition induces autophagy in cancer cells. Cancer Biol Ther (2012) 1.01
Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer. Clin Cancer Res (2004) 1.01
Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR-2). FASEB J (2005) 1.00
Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pflugers Arch (2011) 1.00
Ephrin-B2 overexpression enhances integrin-mediated ECM-attachment and migration of B16 melanoma cells. Int J Oncol (2005) 0.99
Metastatic adenocarcinoma of the colon presenting as a mass in the mandible. Head Neck (2005) 0.99
AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated. Pflugers Arch (2009) 0.97
Cl- interference with the epithelial Na+ channel ENaC. J Biol Chem (2005) 0.97
Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells. J Biol Chem (2008) 0.96
Activation of ion secretion via proteinase-activated receptor-2 in human colon. Am J Physiol Gastrointest Liver Physiol (2002) 0.96
Cancer of the head and neck is the sixth most common cancer worldwide. Curr Probl Surg (2009) 0.95
Regulation of the epithelial Na+ channel by the protein kinase CK2. J Biol Chem (2008) 0.95
Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea. Pflugers Arch (2002) 0.95
Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells. Biochim Biophys Acta (2010) 0.95
Role of KCNMA1 in breast cancer. PLoS One (2012) 0.94
Correction of the CF defect by curcumin: hypes and disappointments. Bioessays (2005) 0.94
Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR. Cell Physiol Biochem (2009) 0.94
Quality of life in head and neck cancer patients: impact of HPV and primary treatment modality. Laryngoscope (2013) 0.94
Demonstration of transoral surgery in cadaveric specimens with the medrobotics flex system. Laryngoscope (2013) 0.93
Assessment of CFTR function in rectal biopsies for the diagnosis of cystic fibrosis. J Cyst Fibros (2004) 0.93
Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells. J Am Soc Nephrol (2009) 0.92
Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo. Mol Cancer Ther (2007) 0.92
Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis. PLoS One (2012) 0.92
Expression and functional significance of the Ca(2+)-activated Cl(-) channel ANO6 in dendritic cells. Cell Physiol Biochem (2012) 0.92
CFTR is activated through stimulation of purinergic P2Y2 receptors. Pflugers Arch (2008) 0.91
Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia. FASEB J (2006) 0.91
Characterization of novel airway submucosal gland cell models for cystic fibrosis studies. Cell Physiol Biochem (2005) 0.91
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Hum Mol Genet (2002) 0.91
Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways. Cell Biochem Biophys (2002) 0.91