Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.

Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife (2017) 0.75

The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88

Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43

Phaser crystallographic software. J Appl Crystallogr (2007) 108.34

Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46

Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr (2005) 61.38

MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A (2006) 4.45

The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction. Science (2003) 3.41

An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol (2005) 2.97

The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase. Nature (1992) 2.64

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J (2009) 1.97

Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. Cell (2001) 1.60

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases. Structure (2014) 1.50

Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation. FEBS Lett (2004) 1.42

Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets. J Biol Chem (1989) 1.17

Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J Biol Chem (2007) 1.12

Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase. J Am Chem Soc (2005) 1.05

Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorg Med Chem (2009) 1.04

Synthesis of biaryls and polyaryls by ligand-free Suzuki reaction in aqueous phase. J Org Chem (2006) 1.02

Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. J Biol Chem (2013) 0.96

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes. Proc Natl Acad Sci U S A (2010) 0.96

Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission. Cell Host Microbe (2012) 0.95

Efficiency of hit generation and structural characterization in fragment-based ligand discovery. Curr Opin Chem Biol (2011) 0.94

Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes. FASEB J (2007) 0.93

Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2. J Biol Chem (2004) 0.92

Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway. J Cell Sci (2007) 0.92

Phosphoinositide phosphatases and disease. J Lipid Res (2008) 0.92

Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering. J Biomol Screen (2010) 0.87

Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha. ACS Chem Biol (2007) 0.87

Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha. Chembiochem (2008) 0.86

Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies. ACS Chem Biol (2014) 0.82

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery. ACS Chem Biol (2012) 0.81

Multivalent benzene polyphosphate derivatives are non-Ca(2+)-mobilizing Ins(1,4,5)P3 receptor antagonists. Messenger (Los Angel) (2012) 0.77