A chemo-mechanical free-energy-based approach to model durotaxis and extracellular stiffness-dependent contraction and polarization of cells.

PubWeight™: 0.79‹?›

🔗 View Article (PMID 26855753)

Published in Interface Focus on February 06, 2016

Authors

Vivek B Shenoy1, Hailong Wang1, Xiao Wang1

Author Affiliations

1: Department of Materials Science and Engineering , University of Pennsylvania , Philadelphia, PA 19104 , USA.

Articles cited by this

Tissue cells feel and respond to the stiffness of their substrate. Science (2005) 23.42

Cell movement is guided by the rigidity of the substrate. Biophys J (2000) 13.84

Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol (1996) 9.95

Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell (2006) 7.35

Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol (2006) 5.54

Sub-piconewton force fluctuations of actomyosin in vitro. Nature (1991) 3.89

Is the mechanical activity of epithelial cells controlled by deformations or forces? Biophys J (2005) 3.43

Actin stress fibres. J Cell Sci (2007) 3.28

An anisotropic biphasic theory of tissue-equivalent mechanics: the interplay among cell traction, fibrillar network deformation, fibril alignment, and cell contact guidance. J Biomech Eng (1997) 2.72

Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates. Proc Natl Acad Sci U S A (2007) 2.47

The mechanical integrin cycle. J Cell Sci (2009) 2.28

Understanding cytokinesis: lessons from fission yeast. Nat Rev Mol Cell Biol (2010) 2.25

Optimal matrix rigidity for stress fiber polarization in stem cells. Nat Phys (2010) 2.16

Single-cell response to stiffness exhibits muscle-like behavior. Proc Natl Acad Sci U S A (2009) 2.11

Viscoelastic properties of the cell nucleus. Biochem Biophys Res Commun (2000) 2.08

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nat Commun (2012) 1.96

A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Eng Part A (2012) 1.95

Rho-kinase--mediated contraction of isolated stress fibers. J Cell Biol (2001) 1.92

Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proc Natl Acad Sci U S A (2009) 1.89

A bio-chemo-mechanical model for cell contractility. Proc Natl Acad Sci U S A (2006) 1.82

Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. Tissue Eng Part A (2010) 1.77

Mechanics and contraction dynamics of single platelets and implications for clot stiffening. Nat Mater (2010) 1.73

Structure and polymerization of Acanthamoeba myosin-II filaments. J Cell Biol (1982) 1.68

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. J Cell Biol (2012) 1.65

Rods, tori, and honeycombs: the directed self-assembly of microtissues with prescribed microscale geometries. FASEB J (2007) 1.57

Nuclear mechanics and mechanotransduction in health and disease. Curr Biol (2013) 1.51

A cell-based constitutive relation for bio-artificial tissues. Biophys J (2000) 1.42

Broken nuclei--lamins, nuclear mechanics, and disease. Trends Cell Biol (2013) 1.25

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb) (2010) 1.23

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer. Cancer Res (2010) 1.14

A new lock-step mechanism of matrix remodelling based on subcellular contractile events. J Cell Sci (2010) 1.10

Cellular mechanosensing: getting to the nucleus of it all. Prog Biophys Mol Biol (2014) 0.99

Necking and failure of constrained 3D microtissues induced by cellular tension. Proc Natl Acad Sci U S A (2013) 0.96

A finite element solution for the anisotropic biphasic theory of tissue-equivalent mechanics: the effect of contact guidance on isometric cell traction measurement. J Biomech Eng (1997) 0.95

Fibroblast elongation and dendritic extensions in constrained versus unconstrained microtissues. Cell Motil Cytoskeleton (2009) 0.93

The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation. J R Soc Interface (2012) 0.83