Published in Science on December 08, 1989
Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci U S A (1992) 6.94
Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol (2000) 5.94
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A (1991) 5.60
Heterologous introns can enhance expression of transgenes in mice. Proc Natl Acad Sci U S A (1991) 3.34
Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver. Proc Natl Acad Sci U S A (1991) 2.66
PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev (1997) 2.29
Forward and reverse genetic approaches to behavior in the mouse. Science (1994) 2.20
Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J (1993) 1.86
Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol (1990) 1.80
Pancreatic tumor pathogenesis reflects the causative genetic lesion. Proc Natl Acad Sci U S A (1991) 1.72
Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation. J Virol (1993) 1.54
Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc Natl Acad Sci U S A (1998) 1.49
Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice. Proc Natl Acad Sci U S A (1991) 1.48
High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J (1992) 1.48
In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc Natl Acad Sci U S A (1993) 1.43
MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene. Nucleic Acids Res (1996) 1.36
Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol (1994) 1.26
Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant. Mol Cell Biol (1993) 1.20
Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. Am J Pathol (1992) 1.19
Biomechanics of the cardiovascular system: the aorta as an illustratory example. J R Soc Interface (2006) 1.08
Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. World J Gastroenterol (2005) 1.04
Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16. Proc Natl Acad Sci U S A (1994) 1.02
Perinatal and multigenerational effect of carcinogens: possible contribution to determination of cancer susceptibility. Environ Health Perspect (1992) 0.98
Uniform cell-autonomous tumorigenesis of the choroid plexus by papovavirus large T antigens. Mol Cell Biol (1991) 0.95
Restriction of neuroblastoma to the prostate gland in transgenic mice. Mol Cell Biol (1991) 0.95
Tumors in hepatobiliary tract and pancreatic islet tissues of transgenic mice harboring gastrin simian virus 40 large tumor antigen fusion gene. Proc Natl Acad Sci U S A (1993) 0.88
Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53. J Virol (1991) 0.88
Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T-antigen hybrid gene. Am J Pathol (1990) 0.87
Testing electromagnetic fields for potential carcinogenic activity: a critical review of animal models. Environ Health Perspect (1997) 0.85
EMBO medal review. On transferring genes into stem cells and mice. EMBO J (1990) 0.83
A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. Neoplasia (2005) 0.82
v-src transformation of rat embryo fibroblasts. Inefficient conversion to anchorage-independent growth involves heterogeneity of primary cultures. J Cell Biol (1994) 0.81
Estradiol-dependent uterine leiomyomas in transgenic mice. J Clin Invest (1996) 0.79
Insulinomas derived from hyperplastic intra-hepatic islet transplants. Am J Pathol (1998) 0.79
The tsA58 simian virus 40 large tumor antigen disrupts megakaryocyte differentiation in transgenic mice. Proc Natl Acad Sci U S A (1994) 0.79
Transgenic mouse lines that are immunologically tolerant and nontolerant to herpes simplex virus glycoprotein D. J Virol (1991) 0.77
GI GEMs: genetically engineered mouse models of gastrointestinal disease. Gastroenterology (2010) 0.77
Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse. Transgenic Res (2009) 0.76
Limitations of the cancer stem cell theory. Cytotechnology (2008) 0.76
Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice. Nucleic Acids Res (1996) 0.75
Transgenic mouse models of self-tolerance and autoreactivity by the immune system. Annu Rev Cell Biol (1990) 1.15
Tumorigenic latency and separable stages during fibrosarcoma development in transgenic mice carrying papillomavirus genomes. Princess Takamatsu Symp (1989) 0.75