Published in J Physiol on April 06, 2016
Advances in intracellular Ca(2+) signalling. J Physiol (2016) 0.75
Tobacco Smoke Constituents Trigger Cytoplasmic Calcium Release. Appl In Vitro Toxicol (2017) 0.75
Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol (2009) 23.08
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol (2005) 13.11
A model for receptor-regulated calcium entry. Cell Calcium (1986) 12.47
Store-operated calcium channels. Physiol Rev (2005) 11.95
Calcium signaling. Cell (2007) 11.09
Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature (1992) 10.22
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science (2006) 9.61
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature (2005) 8.96
Capacitative calcium entry revisited. Cell Calcium (1991) 7.73
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature (2006) 7.22
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Calcium release-activated calcium current in rat mast cells. J Physiol (1993) 6.33
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions. J Cell Biol (2006) 5.58
The TRP superfamily of cation channels. Sci STKE (2005) 5.29
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem (2006) 4.98
Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors. J Physiol (2001) 4.78
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback. J Gen Physiol (1995) 3.75
STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. Cell (2007) 3.75
The functional network of ion channels in T lymphocytes. Immunol Rev (2009) 3.21
Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell (2009) 3.20
STIMulating store-operated Ca(2+) entry. Nat Cell Biol (2009) 3.18
Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol (2003) 3.10
TRP channels: an overview. Cell Calcium (2005) 2.98
Systematic review of medical treatment in melanoma: current status and future prospects. Oncologist (2011) 2.89
Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem (2007) 2.63
Distinct properties of CRAC and MIC channels in RBL cells. J Gen Physiol (2002) 2.59
Crystal structure of the calcium release-activated calcium channel Orai. Science (2012) 2.58
The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science (2010) 2.46
Cancer stem cells versus phenotype-switching in melanoma. Pigment Cell Melanoma Res (2010) 2.43
Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res (1998) 2.43
Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell (2013) 2.43
ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond. Immunol Rev (2009) 2.43
Calcium signaling in lymphocytes. Curr Opin Immunol (2008) 2.38
Conductance and permeation of monovalent cations through depletion-activated Ca2+ channels (ICRAC) in Jurkat T cells. Biophys J (1996) 2.36
The store-operated calcium current I(CRAC): nonlinear activation by InsP3 and dissociation from calcium release. Cell (1997) 2.30
Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell (2010) 2.29
A GTP-dependent step in the activation mechanism of capacitative calcium influx. J Biol Chem (1993) 2.15
CaT1 and the calcium release-activated calcium channel manifest distinct pore properties. J Biol Chem (2001) 2.12
Emerging perspectives in store-operated Ca2+ entry: roles of Orai, Stim and TRP. Biochim Biophys Acta (2006) 2.00
Calcium signaling in immune cells. Nat Immunol (2009) 1.97
Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol (2009) 1.96
Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes. Proc Natl Acad Sci U S A (2000) 1.92
Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J Biol Chem (2004) 1.88
Dissecting ICRAC, a store-operated calcium current. Trends Biochem Sci (2007) 1.82
Store-operated CRAC channels: function in health and disease. Nat Rev Drug Discov (2010) 1.82
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J (2007) 1.77
TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal (2009) 1.75
Melastatin expression and prognosis in cutaneous malignant melanoma. J Clin Oncol (2001) 1.75
CRAC channelopathies. Pflugers Arch (2010) 1.71
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell (2013) 1.71
I(ARC), a novel arachidonate-regulated, noncapacitative Ca(2+) entry channel. J Biol Chem (2000) 1.66
Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res (2004) 1.64
Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. Proc Natl Acad Sci U S A (2011) 1.64
Decoding cytosolic Ca2+ oscillations. Trends Biochem Sci (2010) 1.63
Calcium and barium permeation through calcium release-activated calcium (CRAC) channels. Pflugers Arch (1995) 1.62
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal (2010) 1.44
Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A (2011) 1.44
Checking your SOCCs and feet: the molecular mechanisms of Ca2+ entry in skeletal muscle. J Physiol (2009) 1.42
Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake. EMBO J (2002) 1.42
Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca(2+) current I(CRAC). EMBO J (2000) 1.40
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
The STIM/Orai coupling machinery. Channels (Austin) (2008) 1.35
Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells. Cell Death Dis (2010) 1.29
Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors. Curr Biol (2009) 1.26
Modulation of plasma membrane calcium-ATPase activity by local calcium microdomains near CRAC channels in human T cells. J Physiol (2004) 1.26
Melanoma and the tumor microenvironment. Curr Oncol Rep (2008) 1.26
Mechanistic view on domains mediating STIM1-Orai coupling. Immunol Rev (2009) 1.24
Arachidonic acid, ARC channels, and Orai proteins. Cell Calcium (2009) 1.21
ORAI1-mediated calcium influx in lactation and in breast cancer. Mol Cancer Ther (2011) 1.21
Orai3 is an estrogen receptor α-regulated Ca²⁺ channel that promotes tumorigenesis. FASEB J (2012) 1.21
Patterns of melastatin mRNA expression in melanocytic tumors. Hum Pathol (2000) 1.21
STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+ release. J Cell Biol (2011) 1.20
Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J Clin Invest (1996) 1.13
STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion. Pflugers Arch (2013) 1.13
Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. Proc Natl Acad Sci U S A (2012) 1.12
Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria. J Biol Chem (2011) 1.11
Melanoma. Nat Rev Dis Prim (2015) 1.10
CRAC channels and Ca2+ signaling in mast cells. Immunol Rev (2009) 1.09
Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms. Mol Cell (2015) 1.09
Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication. Biochim Biophys Acta (2006) 1.08
UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Proc Natl Acad Sci U S A (2013) 1.06
STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression. Oncogene (2014) 1.04
Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration. PLoS One (2014) 1.03
Calcium regulation of keratinocyte differentiation. Expert Rev Endocrinol Metab (2012) 1.03
STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion. J Cell Biol (2014) 1.01
ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells. Biochim Biophys Acta (2012) 1.01
Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth. Carcinogenesis (2012) 1.00
Complex role of STIM1 in the activation of store-independent Orai1/3 channels. J Gen Physiol (2014) 0.99
Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma. Biochem Biophys Res Commun (2014) 0.98
Role of TRPM in melanocytes and melanoma. Exp Dermatol (2012) 0.98
Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells. Biochim Biophys Acta (2011) 0.98
Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer. Cancer Cell Int (2014) 0.96
ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance. Cell Calcium (2011) 0.95
Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells. Cell Calcium (2010) 0.95
Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma. Biochim Biophys Acta (2014) 0.95
Orai1 calcium channels in the vasculature. Pflugers Arch (2012) 0.95
ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes. J Invest Dermatol (2012) 0.94
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α. EMBO Mol Med (2016) 0.85
PIM kinases as therapeutic targets against advanced melanoma. Oncotarget (2016) 0.78
Enhancing the evaluation of PI3K inhibitors through 3D melanoma models. Pigment Cell Melanoma Res (2016) 0.75