Store-operated calcium channels.

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Published in Physiol Rev on April 01, 2005

Authors

Anant B Parekh1, James W Putney

Author Affiliations

1: Department of Physiology, University of Oxford, United Kingdom. anant.parekh@physiol.ox.ac.uk

Articles citing this

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STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature (2005) 8.96

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A (2006) 7.26

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane. J Cell Biol (2006) 6.88

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The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions. J Cell Biol (2006) 5.58

Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem (2006) 5.32

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Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11

SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature (2008) 3.67

Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol (2012) 3.59

Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol (2007) 3.57

STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47

Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2006) 3.47

STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. Proc Natl Acad Sci U S A (2006) 3.32

Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21

STIMulating store-operated Ca(2+) entry. Nat Cell Biol (2009) 3.18

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels. J Biol Chem (2009) 2.97

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. Nat Cell Biol (2008) 2.89

Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem (2008) 2.75

STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Proc Natl Acad Sci U S A (2009) 2.67

Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem (2007) 2.63

Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res (2008) 2.60

Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal (2013) 2.59

Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration. FASEB J (2009) 2.36

Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem (2008) 2.32

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy. J Physiol (2008) 2.29

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The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J (2006) 2.24

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Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc Natl Acad Sci U S A (2007) 2.17

STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane. J Physiol (2006) 2.17

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J (2007) 2.16

STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol (2009) 2.15

ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia. J Allergy Clin Immunol (2009) 2.09

T cell activation requires mitochondrial translocation to the immunological synapse. Proc Natl Acad Sci U S A (2007) 2.06

TRPC channels as STIM1-regulated store-operated channels. Cell Calcium (2007) 2.04

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Ca2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture. Am J Physiol Cell Physiol (2008) 2.01

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Orai1 mutations alter ion permeation and Ca2+-dependent fast inactivation of CRAC channels: evidence for coupling of permeation and gating. J Gen Physiol (2007) 1.87

TRPC channels function independently of STIM1 and Orai1. J Physiol (2009) 1.83

Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function. J Physiol (2008) 1.83

Store-operated CRAC channels: function in health and disease. Nat Rev Drug Discov (2010) 1.82

Ca2+-store-dependent and -independent reversal of Stim1 localization and function. J Cell Sci (2008) 1.80

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation. EMBO J (2011) 1.80

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J Cell Biol (2010) 1.77

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Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats. Am J Physiol Heart Circ Physiol (2010) 1.77

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J (2007) 1.77

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Ion channels and transporters in lymphocyte function and immunity. Nat Rev Immunol (2012) 1.74

Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels. J Biol Chem (2008) 1.74

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. Circulation (2013) 1.73

Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J Leukoc Biol (2010) 1.73

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Store-operated calcium channels: new perspectives on mechanism and function. Cold Spring Harb Perspect Biol (2011) 1.72

Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2014) 1.72

CRAC channelopathies. Pflugers Arch (2010) 1.71

Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE). J Biol Chem (2008) 1.71

STIM protein coupling in the activation of Orai channels. Proc Natl Acad Sci U S A (2009) 1.70

Some assembly required: constructing the elementary units of store-operated Ca2+ entry. Cell Calcium (2007) 1.70

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Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+. Sci Signal (2012) 1.62

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RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58

Methods for studying store-operated calcium entry. Methods (2008) 1.57

Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode. J Gen Physiol (2006) 1.57

Calcium oscillations. Cold Spring Harb Perspect Biol (2011) 1.56

Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels. J Physiol (2007) 1.54

Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. J Physiol (2007) 1.53

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood (2009) 1.53

Pore architecture of the ORAI1 store-operated calcium channel. Proc Natl Acad Sci U S A (2010) 1.52

Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. Nat Cell Biol (2009) 1.51

Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression. Nat Chem Biol (2011) 1.50

Calcium channels and pumps in cancer: changes and consequences. J Biol Chem (2012) 1.49

Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism. Proc Natl Acad Sci U S A (2006) 1.48

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits. Cell Res (2010) 1.48

Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1. J Physiol (2008) 1.48

Mitochondria and Ca(2+) signaling: old guests, new functions. Pflugers Arch (2007) 1.47

Store-Operated Calcium Channels. Physiol Rev (2015) 1.46

Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions. PLoS Biol (2011) 1.45

Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A (2011) 1.44

Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia. Am J Physiol Lung Cell Mol Physiol (2008) 1.42

Immunodeficiency due to mutations in ORAI1 and STIM1. Clin Immunol (2010) 1.39

Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant. J Biol Chem (2009) 1.39

An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39

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Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem (2006) 5.32

Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol (2007) 3.57

STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER. Curr Biol (2008) 2.79

Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels. J Biol Chem (2007) 2.58

Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem (2008) 2.32

Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition. J Biol Chem (2002) 2.18

Emerging perspectives in store-operated Ca2+ entry: roles of Orai, Stim and TRP. Biochim Biophys Acta (2006) 2.00

Capacitative calcium entry supports calcium oscillations in human embryonic kidney cells. J Physiol (2004) 1.92

TRPC channels function independently of STIM1 and Orai1. J Physiol (2009) 1.83

Ca2+-store-dependent and -independent reversal of Stim1 localization and function. J Cell Sci (2008) 1.80

Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels. J Biol Chem (2003) 1.70

Activation and regulation of store-operated calcium entry. J Cell Mol Med (2010) 1.70

The mammalian TRPC cation channels. Biochim Biophys Acta (2004) 1.62

Methods for studying store-operated calcium entry. Methods (2008) 1.57

Calcium oscillations. Cold Spring Harb Perspect Biol (2011) 1.56

Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1. J Cell Sci (2007) 1.55

Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. J Physiol (2007) 1.53

The TRPC3/6/7 subfamily of cation channels. Cell Calcium (2003) 1.52

Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. Nat Cell Biol (2009) 1.51

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Negative regulation of TRPC3 channels by protein kinase C-mediated phosphorylation of serine 712. Mol Pharmacol (2004) 1.42

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