Crystal structure of the Rous sarcoma virus intasome.

PubWeight™: 0.91‹?›

🔗 View Article (PMID 26887497)

Published in Nature on February 18, 2016

Authors

Zhiqi Yin1,2,3, Ke Shi1,2,3, Surajit Banerjee4, Krishan K Pandey5, Sibes Bera5, Duane P Grandgenett5, Hideki Aihara1,2,3

Author Affiliations

1: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
2: Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
3: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
4: Northeastern Collaborative Access Team, Cornell University, Advanced Photon Source, Lemont, Illinois 60439, USA.
5: Institute for Molecular Virology, St. Louis University Health Sciences Center, St. Louis, Missouri 63104, USA.

Articles citing this

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome. Science (2017) 1.15

A supramolecular assembly mediates lentiviral DNA integration. Science (2017) 1.10

Retroviral DNA Integration. Chem Rev (2016) 0.90

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature (2016) 0.89

What Integration Sites Tell Us about HIV Persistence. Cell Host Microbe (2016) 0.78

Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) to Facilitate the IN Assembly and Non-enzymatic Function Through the IN Precursor Form with Reverse Transcriptase. J Virol (2016) 0.77

X-ray Crystal Structure of the N-Terminal Region of Moloney Murine Leukemia Virus Integrase and its Implications for Viral DNA Recognition. Proteins (2017) 0.75

Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal. Elife (2017) 0.75

The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical. Structure (2016) 0.75

Integration site selection by retroviruses and transposable elements in eukaryotes. Nat Rev Genet (2017) 0.75

A C-terminal "Tail" Region in the Rous Sarcoma Virus Integrase Provides High Plasticity of Functional Integrase Oligomerization during Intasome Assembly. J Biol Chem (2017) 0.75

DNA minicircles clarify the specific role of DNA structure on retroviral integration. Nucleic Acids Res (2016) 0.75

Retroviral integrase protein and intasome nucleoprotein complex structures. World J Biol Chem (2017) 0.75

Dissecting Virus Infectious Cycles by Cryo-Electron Microscopy. PLoS Pathog (2016) 0.75

Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration. Retrovirology (2017) 0.75

Articles cited by this

PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52

Phaser crystallographic software. J Appl Crystallogr (2007) 108.34

Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46

XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46

Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61

Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55

Linking crystallographic model and data quality. Science (2012) 12.13

Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: a new viral function required for productive infection. Cell (1984) 7.16

Deciphering key features in protein structures with the new ENDscript server. Nucleic Acids Res (2014) 6.82

A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proc Natl Acad Sci U S A (1984) 5.81

Retroviral intasome assembly and inhibition of DNA strand transfer. Nature (2010) 4.99

The retrovirus pol gene encodes a product required for DNA integration: identification of a retrovirus int locus. Proc Natl Acad Sci U S A (1984) 4.81

A 32,000-dalton nucleic acid-binding protein from avian retravirus cores possesses DNA endonuclease activity. Virology (1978) 4.35

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J (2001) 3.23

THE PARTICIPATION OF DNA IN ROUS SARCOMA VIRUS PRODUCTION. Virology (1964) 2.70

The mechanism of retroviral integration from X-ray structures of its key intermediates. Nature (2010) 2.58

Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses. J Virol (2005) 2.29

Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir. J Virol (2011) 1.95

Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration. J Biol Chem (2005) 1.84

Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome. J Biol Chem (1999) 1.77

Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes. EMBO J (2001) 1.77

HIV DNA integration. Cold Spring Harb Perspect Med (2012) 1.73

Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase. J Mol Biol (2000) 1.69

Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: critical residues for protein oligomerization and DNA binding. J Virol (1998) 1.58

The μ transpososome structure sheds light on DDE recombinase evolution. Nature (2012) 1.22

Structural basis for retroviral integration into nucleosomes. Nature (2015) 1.18

An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA. J Virol (2003) 1.16

Avian retrovirus U3 and U5 DNA inverted repeats. Role Of nonsymmetrical nucleotides in promoting full-site integration by purified virion and bacterial recombinant integrases. J Biol Chem (1997) 1.10

Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA. Structure (2012) 1.07

Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration. Protein Sci (2012) 0.98

Molecular and genetic determinants of rous sarcoma virus integrase for concerted DNA integration. J Virol (2003) 0.96

Structural organization of avian retrovirus integrase in assembled intasomes mediating full-site integration. J Biol Chem (2004) 0.93

Key determinants of target DNA recognition by retroviral intasomes. Retrovirology (2015) 0.93

Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking. J Biol Chem (2011) 0.90

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature (2016) 0.89

A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding. PLoS One (2013) 0.82

Structural and sequencing analysis of local target DNA recognition by MLV integrase. Nucleic Acids Res (2015) 0.82

Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis. PLoS One (2011) 0.81

Rous sarcoma virus synaptic complex capable of concerted integration is kinetically trapped by human immunodeficiency virus integrase strand transfer inhibitors. J Biol Chem (2014) 0.78

Atomic Resolution Structures of the Core Domain of Avian Sarcoma Virus Integrase and Its D64N Mutant. Biochemistry (1999) 0.77