Probing the Complexities of Astrocyte Calcium Signaling.

PubWeight™: 0.89‹?›

🔗 View Article (PMID 26896246)

Published in Trends Cell Biol on February 16, 2016

Authors

Eiji Shigetomi1, Sandip Patel2, Baljit S Khakh3

Author Affiliations

1: Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.
2: Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
3: Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA; Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA. Electronic address: bkhakh@mednet.ucla.edu.

Articles cited by this

(truncated to the top 100)

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature (1997) 18.83

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci (2008) 17.27

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods (2009) 13.39

Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature (2013) 12.01

A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein. Nat Biotechnol (2001) 8.45

Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci U S A (2004) 6.33

Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci (2012) 6.09

Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling. Science (1990) 6.02

GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci (2004) 5.92

Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J Neurosci (2002) 5.14

An expanded palette of genetically encoded Ca²⁺ indicators. Science (2011) 5.05

Modulation of visual responses by behavioral state in mouse visual cortex. Neuron (2010) 4.84

Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science (2008) 4.82

Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling. Science (2010) 3.77

Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol (2010) 3.38

Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science (2013) 3.35

A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci (2012) 3.13

Three-dimensional relationships between hippocampal synapses and astrocytes. J Neurosci (1999) 3.12

Astrocytes are endogenous regulators of basal transmission at central synapses. Cell (2011) 2.97

Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells. Nat Neurosci (1999) 2.87

Neuronal activity triggers calcium waves in hippocampal astrocyte networks. Neuron (1992) 2.85

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Front Mol Neurosci (2013) 2.79

Intercellular signaling in glial cells: calcium waves and oscillations in response to mechanical stimulation and glutamate. Neuron (1991) 2.78

Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell (2013) 2.71

Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol (2010) 2.68

Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science (2009) 2.65

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol (2005) 2.57

Calcium dynamics of cortical astrocytic networks in vivo. PLoS Biol (2004) 2.51

Spontaneous network activity visualized by ultrasensitive Ca(2+) indicators, yellow Cameleon-Nano. Nat Methods (2010) 2.47

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nat Neurosci (2014) 2.38

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nat Neurosci (2010) 2.30

Norepinephrine controls astroglial responsiveness to local circuit activity. Neuron (2014) 2.17

Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo. J Neurosci (2011) 2.17

Motor behavior activates Bergmann glial networks. Neuron (2009) 2.16

Loss of IP3 receptor-dependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. J Neurosci (2008) 2.14

Local Ca2+ detection and modulation of synaptic release by astrocytes. Nat Neurosci (2011) 2.06

Sensorimotor mismatch signals in primary visual cortex of the behaving mouse. Neuron (2012) 2.01

Neural circuits. Labeling of active neural circuits in vivo with designed calcium integrators. Science (2015) 2.00

Gliotransmitters travel in time and space. Neuron (2014) 1.99

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A (2009) 1.87

Heterogeneity of astrocytic form and function. Methods Mol Biol (2012) 1.83

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J Gen Physiol (2013) 1.82

Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance. Neuron (2015) 1.79

Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy. Nat Neurosci (2005) 1.78

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. Proc Natl Acad Sci U S A (2012) 1.77

Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo. Cereb Cortex (2008) 1.76

Astrocytic neurotransmitter receptors in situ and in vivo. Prog Neurobiol (1997) 1.76

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Nat Neurosci (2010) 1.71

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling. Trends Cell Biol (2010) 1.67

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci (2011) 1.67

Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice cultures. J Neurosci Methods (2005) 1.64

Reporting neural activity with genetically encoded calcium indicators. Brain Cell Biol (2008) 1.64

Genetically encoded green fluorescent Ca2+ indicators with improved detectability for neuronal Ca2+ signals. PLoS One (2012) 1.52

Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci (2015) 1.50

Sorting out astrocyte physiology from pharmacology. Annu Rev Pharmacol Toxicol (2009) 1.38

TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release. J Neurosci (2013) 1.36

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice. Cell Calcium (2013) 1.34

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects. Hum Mol Genet (2010) 1.34

Glial calcium and diseases of the nervous system. Cell Calcium (2009) 1.34

Fast GCaMPs for improved tracking of neuronal activity. Nat Commun (2013) 1.30

Nucleus basalis-enabled stimulus-specific plasticity in the visual cortex is mediated by astrocytes. Proc Natl Acad Sci U S A (2012) 1.30

Astrocytic Gq-GPCR-linked IP3R-dependent Ca2+ signaling does not mediate neurovascular coupling in mouse visual cortex in vivo. J Neurosci (2014) 1.29

Astrocyte Ca²⁺ signalling: an unexpected complexity. Nat Rev Neurosci (2014) 1.27

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. J Biol Chem (2010) 1.25

Calcium dynamics in astrocyte processes during neurovascular coupling. Nat Neurosci (2014) 1.24

Cell type- and brain region-resolved mouse brain proteome. Nat Neurosci (2015) 1.24

Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps. J Neurosci (2011) 1.22

Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway. Neuron (2014) 1.20

Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo. Nat Neurosci (2015) 1.18

Cellular level brain imaging in behaving mammals: an engineering approach. Neuron (2015) 1.17

How do astrocytes participate in neural plasticity? Cold Spring Harb Perspect Biol (2014) 1.17

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA. Nat Commun (2014) 1.12

Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters. Neuron Glia Biol (2010) 1.09

In vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca(2+) indicator. Cell Rep (2014) 1.08

Transgenic mice expressing a cameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivo. J Neurosci Methods (2009) 1.07

Do glia drive synaptic and cognitive impairment in disease? Nat Neurosci (2015) 1.07

Adrenoceptors in brain: cellular gene expression and effects on astrocytic metabolism and [Ca(2+)]i. Neurochem Int (2010) 1.06

Neural signalling. Neuromodulatory astrocytes. Curr Biol (1994) 1.06

Astrocytes Control Synapse Formation, Function, and Elimination. Cold Spring Harb Perspect Biol (2015) 1.05

Astrocyte calcium signaling: from observations to functions and the challenges therein. Cold Spring Harb Perspect Biol (2015) 1.03

Do astrocytes process neural information? Prog Brain Res (1992) 1.03

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia (2013) 1.02

Genetically encoded calcium indicators and astrocyte calcium microdomains. Neuroscientist (2012) 1.01

Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse. Neuron (2014) 1.01

Quantitative two-photon Ca2+ imaging via fluorescence lifetime analysis. Cell Calcium (2006) 0.99

Monitoring activity in neural circuits with genetically encoded indicators. Front Mol Neurosci (2014) 0.97

Imaging calcium signals in vivo: a powerful tool in physiology and pharmacology. Br J Pharmacol (2011) 0.97

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model. Nat Commun (2014) 0.96

Tonic Local Brain Blood Flow Control by Astrocytes Independent of Phasic Neurovascular Coupling. J Neurosci (2015) 0.96

Photo-physical properties of Ca2+-indicator dyes suitable for two-photon fluorescence-lifetime recordings. J Microsc (2007) 0.93

α7 Nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model. PLoS One (2013) 0.91

Dynamics of Ionic Shifts in Cortical Spreading Depression. Cereb Cortex (2015) 0.91

New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling. J Neurosci (2015) 0.89

Tri-dimensional morphometric analysis of astrocytic processes with high voltage electron microscopy of thick Golgi preparations. J Neurocytol (2004) 0.88

Astrocyte IP3R2-dependent Ca(2+) signaling is not a major modulator of neuronal pathways governing behavior. Front Behav Neurosci (2014) 0.87

Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients. J Alzheimers Dis (2014) 0.87

Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types. Methods Mol Biol (2012) 0.86

Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration. Glia (2014) 0.86

Disentangling calcium-driven astrocyte physiology. Nat Rev Neurosci (2015) 0.85

Time-Resolved Imaging Reveals Heterogeneous Landscapes of Nanomolar Ca(2+) in Neurons and Astroglia. Neuron (2015) 0.84