Published in Acta Pharm Sin B on September 03, 2015
Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues. Sci Rep (2016) 0.80
Functional and molecular insights of hydrogen sulfide signaling and protein sulfhydration. J Mol Biol (2016) 0.80
Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury. J Biol Chem (2016) 0.75
An update on diabetic kidney disease, oxidative stress and antioxidant agents. J Renal Inj Prev (2017) 0.75
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
Autophagy regulates lipid metabolism. Nature (2009) 13.33
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
AMPK in Health and Disease. Physiol Rev (2009) 6.38
AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res (2007) 6.36
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature (2010) 4.12
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell (2013) 2.66
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
Insulin granules. Insulin secretory granules control autophagy in pancreatic β cells. Science (2015) 1.77
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation (2011) 1.57
Autophagy and cancer. Exp Mol Med (2012) 1.57
Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways. J Biol Chem (2009) 1.54
Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. Mol Endocrinol (2007) 1.49
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J Biol Chem (2009) 1.48
APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab (2008) 1.41
AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1. J Cell Biochem (2012) 1.38
High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells. FEBS Lett (2008) 1.28
Inhibition of MTOR disrupts autophagic flux in podocytes. J Am Soc Nephrol (2011) 1.24
Regulation of lipid droplets by autophagy. Trends Endocrinol Metab (2011) 1.23
Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem (2009) 1.23
Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One (2013) 1.23
Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. J Am Soc Nephrol (2013) 1.23
Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes (2012) 1.21
Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. J Mol Cell Cardiol (2011) 1.20
Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet (2003) 1.19
Autophagy in diabetic nephropathy. J Endocrinol (2014) 1.06
AMPK-dependent phosphorylation of ULK1 induces autophagy. Cell Metab (2011) 1.06
The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity. Mini Rev Med Chem (2007) 1.04
Regulation of autophagy by glucose in Mammalian cells. Cells (2012) 0.97
APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway. Mol Endocrinol (2011) 0.97
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes. Diabetes Metab Syndr Obes (2014) 0.96
The double-edged effect of autophagy in pancreatic beta cells and diabetes. Autophagy (2011) 0.96
AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol. Endocrinology (2012) 0.95
Adiponectin lowers glucose production by increasing SOGA. Am J Pathol (2010) 0.94
Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK. Autophagy (2013) 0.93
The interplay between autophagy and apoptosis in the diabetic heart. J Mol Cell Cardiol (2013) 0.92
Cardiomyocyte health: adapting to metabolic changes through autophagy. Trends Endocrinol Metab (2013) 0.92
Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy. Int J Biol Sci (2014) 0.89
Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway. Mol Cell Endocrinol (2015) 0.89
Autophagy modulation as a potential therapeutic target for liver diseases. J Clin Exp Hepatol (2014) 0.87
Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output. Diabetes (2005) 0.85
Adiponectin signaling in the liver. Rev Endocr Metab Disord (2014) 0.84
AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy. Metabolism (2015) 0.82
Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling. Biochim Biophys Acta (2014) 0.81
The physiological deadlock between AMPK and gluconeogenesis: SOGA, a novel protein, may provide the key. Am J Pathol (2010) 0.80
Jinlida granule inhibits palmitic acid induced-intracellular lipid accumulation and enhances autophagy in NIT-1 pancreatic β cells through AMPK activation. J Ethnopharmacol (2014) 0.80
Adenosine monophosphate-activated kinase and its key role in catabolism: structure, regulation, biological activity, and pharmacological activation. Mol Pharmacol (2014) 0.79
Exercising insulin sensitivity: AMPK turns on autophagy! Metabolism (2015) 0.77
Adipose Tissue-Specialized Immunologic Features Might Be the Potential Therapeutic Target of Prospective Medicines for Obesity. J Diabetes Res (2017) 0.75
Interplay between H6PDH and 11β-HSD1 implicated in the pathogenesis of type 2 diabetes mellitus. Bioorg Med Chem Lett (2017) 0.75
Adipogenic miR-27a in adipose tissue upregulates macrophage activation via inhibiting PPARγ of insulin resistance induced by high-fat diet-associated obesity. Exp Cell Res (2017) 0.75