Autophagy and cancer.

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52

Calcium-independent phospholipases A2 and their roles in biological processes and diseases. J Lipid Res (2015) 0.97

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma. Cell Death Dis (2013) 0.96

Autophagy modulation as a target for anticancer drug discovery. Acta Pharmacol Sin (2013) 0.93

Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells. Mol Oncol (2015) 0.92

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells. Drug Des Devel Ther (2015) 0.90

Autophagy paradox and ceramide. Biochim Biophys Acta (2013) 0.89

Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol (2015) 0.88

PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity. PLoS One (2013) 0.88

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications. Cell Death Dis (2015) 0.87

Repurposing drugs in oncology (ReDO)-cimetidine as an anti-cancer agent. Ecancermedicalscience (2014) 0.87

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy. Cell Death Dis (2013) 0.86

Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5. Autophagy (2013) 0.85

Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia. Leukemia (2014) 0.84

Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells. PLoS One (2013) 0.84

Heavy metals and metalloids as autophagy inducing agents: focus on cadmium and arsenic. Cells (2012) 0.84

Araguspongine C induces autophagic death in breast cancer cells through suppression of c-Met and HER2 receptor tyrosine kinase signaling. Mar Drugs (2015) 0.84

Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta (2015) 0.84

Elemene injection induced autophagy protects human hepatoma cancer cells from starvation and undergoing apoptosis. Evid Based Complement Alternat Med (2014) 0.84

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells. Autophagy (2014) 0.83

Genetic modulation of islet β-cell iPLA₂β expression provides evidence for its impact on β-cell apoptosis and autophagy. Islets (2013) 0.83

Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy. Front Oncol (2015) 0.83

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death. Drug Des Devel Ther (2013) 0.82

Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers. Adv Drug Deliv Rev (2015) 0.82

Ulinastatin reduces the resistance of liver cancer cells to epirubicin by inhibiting autophagy. PLoS One (2015) 0.81

Retracted Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis. Cancer Gene Ther (2014) 0.81

Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate. BBA Clin (2015) 0.81

Quantum dots-based immunofluorescent imaging of stromal fibroblasts Caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancer. Int J Mol Sci (2012) 0.80

Correlation of altered expression of the autophagy marker LC3B with poor prognosis in astrocytoma. Biomed Res Int (2014) 0.80

Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells. Mol Med Rep (2015) 0.79

The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription. Sci Rep (2015) 0.79

Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PLoS One (2014) 0.79

Interferon-alpha-2b induces autophagy in hepatocellular carcinoma cells through Beclin1 pathway. Cancer Biol Med (2014) 0.78

Autophagy in 5-Fluorouracil Therapy in Gastrointestinal Cancer: Trends and Challenges. Chin Med J (Engl) (2016) 0.78

Current and emerging biomarkers of cell death in human disease. Biomed Res Int (2014) 0.78

Autophagic flux, a possible mechanism for delayed gentamicin-induced ototoxicity. Sci Rep (2017) 0.78

Spinal autophagy is differently modulated in distinct mouse models of neuropathic pain. Mol Pain (2015) 0.77

Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3). J Biol Chem (2016) 0.77

Crotoxin induces apoptosis and autophagy in human lung carcinoma cells in vitro via activation of the p38MAPK signaling pathway. Acta Pharmacol Sin (2014) 0.77

Modulation of Autophagy by Sorafenib: Effects on Treatment Response. Front Pharmacol (2016) 0.77

5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications. Acta Pharm Sin B (2015) 0.77

Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells. Apoptosis (2016) 0.76

Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy. Oncotarget (2017) 0.76

Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells. Mol Cancer (2015) 0.76

Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy. J Biol Chem (2015) 0.76

Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells. Exp Ther Med (2016) 0.75

Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance. Oncol Lett (2016) 0.75

Anticancer activities of self-assembled molecular bowls containing a phenanthrene-based donor and Ru(II) acceptors. Int J Nanomedicine (2015) 0.75

Inhibition of autophagy results in a reversal of taxol resistance in nasopharyngeal carcinoma by enhancing taxol-induced caspase-dependent apoptosis. Am J Transl Res (2017) 0.75

The inhibition of lung cancer cell migration by AhR-regulated autophagy. Sci Rep (2017) 0.75

A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts. J Biomark (2016) 0.75

Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death. Mol Med Rep (2016) 0.75

A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity. Nat Commun (2017) 0.75

Autophagy Gene Activity May Act As a Key Factor for Sensitivity of Tumor Cells to Oncolytic Vesicular Stomatitis Virus. Iran J Cancer Prev (2016) 0.75

Autophagy inhibits cell death induced by the anti-cancer drug morusin. Am J Cancer Res (2017) 0.75

EWS-FLI1 positively regulates autophagy by increasing ATG4B expression in Ewing sarcoma cells. Int J Mol Med (2017) 0.75

Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer. Int J Mol Sci (2017) 0.75

Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy. Int J Mol Sci (2017) 0.75

Hallmarks of cancer: the next generation. Cell (2011) 140.01

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

High frequency of mutations of the PIK3CA gene in human cancers. Science (2004) 27.94

Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62

Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68

Methods in mammalian autophagy research. Cell (2010) 20.08

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59

Metformin and reduced risk of cancer in diabetic patients. BMJ (2005) 13.04

How to interpret LC3 immunoblotting. Autophagy (2007) 12.30

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy (2007) 11.74

Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29

Autophagy and metabolism. Science (2010) 8.10

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42

Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell (2007) 7.09

Autophagy as a cell death and tumor suppressor mechanism. Oncogene (2004) 6.92

Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78

Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46

Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35

Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics (1999) 6.23

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22

A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res (2001) 5.92

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ (2004) 5.49

The double-edged sword of autophagy modulation in cancer. Clin Cancer Res (2009) 5.46

Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res (2011) 5.40

Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ (2009) 5.28

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood (2007) 4.91

Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem (2005) 4.56

Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell (2007) 4.55

The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther (2011) 4.39

Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem (2001) 4.14

Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat (2007) 3.78

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest (2009) 3.55

Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett (2006) 3.49

Autophagy and cell death. Curr Top Dev Biol (2007) 3.44

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis (1996) 3.40

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37

Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal (2010) 3.35

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest (2009) 3.23

Autophagy as a target for anticancer therapy. Nat Rev Clin Oncol (2011) 3.19

Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res (2008) 3.17

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci U S A (2010) 3.00

Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res (2003) 2.96

Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem (2005) 2.64

Autophagy regulation by p53. Curr Opin Cell Biol (2010) 2.56

The morphology of various types of cell death in prenatal tissues. Teratology (1973) 2.50

Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ (2005) 2.29

Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol (2009) 2.20

Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ (2010) 2.17

Autophagy and cancer therapy. Autophagy (2006) 2.13

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell (2011) 2.09

The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res (2009) 2.03

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res (2010) 2.02

Role and regulation of autophagy in cancer. Biochim Biophys Acta (2009) 2.00

4-Aminoquinolines--past, present, and future: a chemical perspective. Pharmacol Ther (1998) 2.00

The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer (2009) 1.98

Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer (2010) 1.93

Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res (1992) 1.93

Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One (2009) 1.91

Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res (2009) 1.88

The anticancer drug imatinib induces cellular autophagy. Leukemia (2007) 1.84

Autophagy as a therapeutic target in cancer. Cancer Biol Ther (2011) 1.84

Autophagic cell death: Loch Ness monster or endangered species? Autophagy (2011) 1.82

Selective autophagy in cancer development and therapy. Cancer Res (2010) 1.79

Autophagy is a therapeutic target in anticancer drug resistance. Biochim Biophys Acta (2010) 1.77

Rational use of new and existing disease-modifying agents in rheumatoid arthritis. Ann Intern Med (2001) 1.74

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ (2009) 1.67

Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization. Breast Cancer Res Treat (2008) 1.64

Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors. Genes Cancer (2010) 1.63

Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells. Med Oncol (2009) 1.60

Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer. Cancer Res (1995) 1.58

Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther (2011) 1.55

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches. Cell Cycle (2009) 1.54

Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy. FASEB J (2006) 1.53

Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistance. Autophagy (2009) 1.50

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int J Cancer (2009) 1.50

Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev (2008) 1.49

Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. Prostate (2008) 1.45

Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res (2007) 1.45

The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med (2009) 1.43

Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg (2003) 1.41

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci U S A (2009) 1.40

Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy (2011) 1.40

Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res (2009) 1.39

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res (2008) 1.34

Regulation of autophagy through multiple independent hypoxic signaling pathways. Curr Mol Med (2009) 1.32

Autophagy protects LNCaP cells under androgen deprivation conditions. Autophagy (2007) 1.25