Outer membrane vesicles as platform vaccine technology.

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Published in Biotechnol J on September 01, 2015

Authors

Leo van der Pol1, Michiel Stork2, Peter van der Ley3

Author Affiliations

1: Research, Intravacc, Bilthoven, The Netherlands. leo.van.der.pol@intravacc.nl.
2: Product Development, Intravacc, Bilthoven, The Netherlands.
3: Research, Intravacc, Bilthoven, The Netherlands.

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Release of endotoxin in the form of cell wall blebs during in vitro growth of Neisseria meningitidis. J Exp Med (1973) 4.32

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A bilayer-couple model of bacterial outer membrane vesicle biogenesis. MBio (2012) 1.05

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