Published in Clin Epigenetics on February 24, 2016
Why most published research findings are false. PLoS Med (2005) 41.68
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57
CpG-rich islands and the function of DNA methylation. Nature (1986) 24.90
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet (1999) 22.84
Replicating genotype-phenotype associations. Nature (2007) 16.11
The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med (2009) 12.13
Integrative analysis of 111 reference human epigenomes. Nature (2015) 10.32
DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics (2012) 9.31
Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res (2008) 8.62
OpenMx: An Open Source Extended Structural Equation Modeling Framework. Psychometrika (2011) 8.25
Mortality from smoking worldwide. Br Med Bull (1996) 7.87
Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics (2010) 7.78
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature (2013) 6.57
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol (2011) 6.48
Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA (2014) 6.42
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
Accurate and reliable high-throughput detection of copy number variation in the human genome. Genome Res (2006) 5.50
DNA methylation and body-mass index: a genome-wide analysis. Lancet (2014) 5.49
Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet (2011) 5.18
An integrated epigenetic and genetic approach to common human disease. Trends Genet (2004) 4.89
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect (2012) 4.89
Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics (2013) 4.61
Current cigarette smoking among adults--United States, 2005-2013. MMWR Morb Mortal Wkly Rep (2014) 3.76
Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PLoS One (2013) 3.19
DNA methylation signatures in development and aging of the human prefrontal cortex. Am J Hum Genet (2012) 3.17
Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking. Hum Mol Genet (2012) 3.07
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet (2011) 3.07
BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev (2000) 2.83
Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood (2011) 2.71
Reference-free cell mixture adjustments in analysis of DNA methylation data. Bioinformatics (2014) 2.61
Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab (2012) 2.46
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24
Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet (2012) 2.20
The Vietnam Era Twin Registry. Twin Res (2002) 1.95
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet (2013) 1.89
The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. BMC Genomics (2014) 1.57
Smoking, F2RL3 methylation, and prognosis in stable coronary heart disease. Eur Heart J (2012) 1.51
Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol (2011) 1.49
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes (2012) 1.47
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. Epigenetics (2014) 1.47
The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood. Am J Med Genet B Neuropsychiatr Genet (2010) 1.46
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci. Hum Mol Genet (2015) 1.45
CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study. Environ Health Perspect (2014) 1.44
Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. Hum Genet (2013) 1.43
X chromosome regulation: diverse patterns in development, tissues and disease. Nat Rev Genet (2014) 1.36
Differences in smoking associated DNA methylation patterns in South Asians and Europeans. Clin Epigenetics (2014) 1.33
Comparison of the DNA methylation profiles of human peripheral blood cells and transformed B-lymphocytes. Hum Genet (2010) 1.31
Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Biol Psychiatry (2008) 1.27
Role of the transcriptional corepressor Bcor in embryonic stem cell differentiation and early embryonic development. PLoS One (2008) 1.26
Epigenome-wide association study of fasting blood lipids in the Genetics of Lipid-lowering Drugs and Diet Network study. Circulation (2014) 1.15
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases. PLoS Genet (2012) 1.14
Depressive symptoms and heart rate variability: evidence for a shared genetic substrate in a study of twins. Psychosom Med (2008) 1.12
Differences in methylation on the active and inactive human X chromosomes. Ann Hum Genet (1985) 1.10
TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia. Blood (2009) 1.01
Epigenetic influences on associations between air pollutants and lung function in elderly men: the normative aging study. Environ Health Perspect (2014) 0.97
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. Hum Mol Genet (2013) 0.97
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. Hum Mol Genet (2013) 0.95
Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation. Int J Epidemiol (2015) 0.94
An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training. Epigenetics (2014) 0.91
Gene-specific DNA methylation association with serum levels of C-reactive protein in African Americans. PLoS One (2013) 0.89
X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation. Genet Epidemiol (2014) 0.89
Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study. Environ Mol Mutagen (2014) 0.89
The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol (2012) 0.87
The Influences of Genetic and Environmental Factors on Methylome-wide Association Studies for Human Diseases. Curr Genet Med Rep (2014) 0.82
Infant sex-specific placental cadmium and DNA methylation associations. Environ Res (2015) 0.81
Epigenomic Indicators of Age in African Americans. Hereditary Genet (2014) 0.77