Published in Nat Genet on March 01, 2003
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci U S A (2006) 10.63
Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat Methods (2010) 9.75
Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69
Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell (2006) 8.53
Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A (2008) 8.39
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res (2004) 7.50
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature (2012) 6.34
DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet (2009) 5.99
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24
Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet (2007) 5.16
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics (2013) 4.61
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60
Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci (2009) 4.53
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med (2007) 4.42
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell (2012) 4.18
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet (2011) 3.95
Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging (2011) 3.83
DNA demethylation dynamics. Cell (2011) 3.82
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet (2009) 3.73
Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. Int J Epidemiol (2012) 3.62
TET enzymes, TDG and the dynamics of DNA demethylation. Nature (2013) 3.49
Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell (2009) 3.42
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Factors underlying variable DNA methylation in a human community cohort. Proc Natl Acad Sci U S A (2012) 3.20
Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell (2014) 3.17
Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet (2010) 3.17
BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions. Genome Biol (2012) 3.13
Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest (2010) 3.12
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell (2013) 3.09
Function and information content of DNA methylation. Nature (2015) 3.09
5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol (2005) 3.05
Epigenetic modifications in pluripotent and differentiated cells. Nat Biotechnol (2010) 3.02
Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J (2004) 2.94
Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol (2004) 2.92
Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet (2012) 2.89
Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet (2011) 2.87
DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell (2009) 2.84
Intra- and interindividual epigenetic variation in human germ cells. Am J Hum Genet (2006) 2.79
DNMT1 maintains progenitor function in self-renewing somatic tissue. Nature (2010) 2.74
Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr (2009) 2.71
The DNA methylation landscape of human early embryos. Nature (2014) 2.67
Epigenetic gene regulation in the bacterial world. Microbiol Mol Biol Rev (2006) 2.66
Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A (2006) 2.63
Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest (2011) 2.62
JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet (2006) 2.57
Age-associated DNA methylation in pediatric populations. Genome Res (2012) 2.53
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med (2007) 2.50
Recruitment of DNA methyltransferase I to DNA repair sites. Proc Natl Acad Sci U S A (2005) 2.50
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity (2011) 2.49
Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet (2010) 2.49
Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J Neurosci (2012) 2.46
Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41
Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci (2010) 2.39
A twin approach to unraveling epigenetics. Trends Genet (2011) 2.38
Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proc Natl Acad Sci U S A (2003) 2.35
Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol (2010) 2.34
Female gametophyte development. Plant Cell (2004) 2.33
Epigenetic mechanisms and the transgenerational effects of maternal care. Front Neuroendocrinol (2008) 2.33
Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol (2010) 2.28
The mutational spectrum of non-CpG DNA varies with CpG content. Genome Res (2010) 2.26
Overcoming transcription activator-like effector (TALE) DNA binding domain sensitivity to cytosine methylation. J Biol Chem (2012) 2.25
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One (2009) 2.23
Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol (2013) 2.20
Association between promoter methylation of serotonin transporter gene and depressive symptoms: a monozygotic twin study. Psychosom Med (2013) 2.19
Folic acid supplements in pregnancy and severe language delay in children. JAMA (2011) 2.18
Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell (2013) 2.16
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med (2006) 2.16
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. J Biol Chem (2003) 2.15
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A (2003) 2.12
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A (2007) 2.11
Housekeeping and tissue-specific genes in mouse tissues. BMC Genomics (2007) 2.06
A longitudinal study of epigenetic variation in twins. Epigenetics (2010) 2.06
Heritable epigenetic mutation of a transposon-flanked Arabidopsis gene due to lack of the chromatin-remodeling factor DDM1. EMBO J (2007) 2.05
Population-specificity of human DNA methylation. Genome Biol (2012) 2.04
DNA methylation as a biomarker for cardiovascular disease risk. PLoS One (2010) 2.04
Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet (2010) 2.03
VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization. Genes Dev (2007) 2.01
Linking the epigenetic 'language' of covalent histone modifications to cancer. Br J Cancer (2004) 2.00
Isochores and tissue-specificity. Nucleic Acids Res (2003) 2.00
Global analysis of genetic, epigenetic and transcriptional polymorphisms in Arabidopsis thaliana using whole genome tiling arrays. PLoS Genet (2008) 1.99
Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns. Breast Cancer Res (2010) 1.97
Hypermethylation of the CpG island near the G4C2 repeat in ALS with a C9orf72 expansion. Am J Hum Genet (2013) 1.97
Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc Natl Acad Sci U S A (2011) 1.95
DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet (2008) 15.45
CpG islands and the regulation of transcription. Genes Dev (2011) 9.50
A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res (2004) 7.50
Reversal of neurological defects in a mouse model of Rett syndrome. Science (2007) 7.09
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature (2011) 3.28
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
The role of MeCP2 in the brain. Annu Rev Cell Dev Biol (2011) 2.84
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73
Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res (2011) 2.51
CpG methylation is targeted to transcription units in an invertebrate genome. Genome Res (2007) 2.47
A temporal threshold for formaldehyde crosslinking and fixation. PLoS One (2009) 2.03
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet (2005) 1.87
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A (2007) 1.84
The major form of MeCP2 has a novel N-terminus generated by alternative splicing. Nucleic Acids Res (2004) 1.79
Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nat Neurosci (2013) 1.74
Kaiso-deficient mice show resistance to intestinal cancer. Mol Cell Biol (2006) 1.67
DNA methylation and Rett syndrome. Hum Mol Genet (2003) 1.62
Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev (2012) 1.55
Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol Cell Biol (2006) 1.52
Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet (2003) 1.44
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A (2003) 1.29
Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome. J Neurosci (2013) 1.26
Mbd2 contributes to DNA methylation-directed repression of the Xist gene. Mol Cell Biol (2007) 1.22
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene (2003) 1.21
Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells. PLoS One (2010) 1.17
Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome. Brain (2012) 1.14
Genomic approaches reveal unexpected genetic divergence within Ciona intestinalis. J Mol Evol (2005) 1.14
The effect of interspecific oocytes on demethylation of sperm DNA. Proc Natl Acad Sci U S A (2004) 1.14
Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows. Hum Mol Genet (2012) 1.10
Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons. Stem Cells (2012) 1.09
Molecular biology. MeCP2 repression goes nonglobal. Science (2003) 1.07
Reversibility of functional deficits in experimental models of Rett syndrome. Biochem Soc Trans (2010) 1.03
MMDiff: quantitative testing for shape changes in ChIP-Seq data sets. BMC Genomics (2013) 1.02
Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Nat Genet (2006) 1.00
MeCP2 and other methyl-CpG binding proteins. Ment Retard Dev Disabil Res Rev (2002) 0.94
Il2 transcription unleashed by active DNA demethylation. Nat Immunol (2003) 0.93
Putting the DNA back into DNA methylation. Nat Genet (2011) 0.92
MBD2 is required for correct spatial gene expression in the gut. Mol Cell Biol (2007) 0.89
MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene (2004) 0.89
Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells. Genome Biol (2014) 0.87
MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells. Pathobiology (2008) 0.86
MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene (2005) 0.82
Identical sets of methylated and nonmethylated genes in Ciona intestinalis sperm and muscle cells. Epigenetics Chromatin (2013) 0.81
A unique DNA methylation signature defines a population of IFN-γ/IL-4 double-positive T cells during helminth infection. Eur J Immunol (2014) 0.80