PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26973648)

Published in Front Immunol on February 29, 2016

Authors

María Rosa López-Huertas1, Jasmine Li2, Anjum Zafar3, Sara Rodríguez-Mora1, Carlota García-Domínguez4, Elena Mateos1, José Alcamí1, Sudha Rao3, Mayte Coiras1

Author Affiliations

1: AIDS Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III , Madrid , Spain.
2: Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne , Melbourne, VIC , Australia.
3: Biomedical Sciences, Faculty of Education, Science, Technology and Mathematics, University of Canberra , Canberra, ACT , Australia.
4: Functional Research Unit in Chronic Diseases, National Center of Microbiology, Instituto de Salud Carlos III , Madrid , Spain.

Articles cited by this

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol (1986) 37.70

The immunological synapse: a molecular machine controlling T cell activation. Science (1999) 17.41

NF-kappaB regulation in the immune system. Nat Rev Immunol (2002) 15.80

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med (2004) 13.55

High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science (1993) 12.22

Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med (2004) 9.11

The survival benefits of AIDS treatment in the United States. J Infect Dis (2006) 7.08

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level. J Immunol (1984) 5.80

Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proc Natl Acad Sci U S A (1998) 5.48

An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Cell (1986) 5.22

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol (1993) 3.68

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature (2014) 3.35

HIV enhancer activity perpetuated by NF-kappa B induction on infection of monocytes. Nature (1991) 2.97

trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis. J Virol (1989) 2.84

Multifaceted activities of the HIV-1 transactivator of transcription, Tat. J Biol Chem (1999) 2.81

Protein kinase C(theta) in T cell activation. Annu Rev Immunol (2002) 2.68

Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Mol Cell Biol (2000) 2.58

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs. Nat Rev Microbiol (2009) 2.47

Cell cycle-dependent activation of Ras. Curr Biol (1996) 2.26

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta. Proc Natl Acad Sci U S A (2000) 2.13

Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes. EMBO J (1995) 2.10

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J Biol Chem (1993) 1.98

Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA. Arch Biochem Biophys (1999) 1.66

Identification of lentivirus tat functional domains through generation of equine infectious anemia virus/human immunodeficiency virus type 1 tat gene chimeras. J Virol (1991) 1.61

Signaling takes shape in the immune system. Cell (2000) 1.60

Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathway. J Virol (1999) 1.60

SC35 and heterogeneous nuclear ribonucleoprotein A/B proteins bind to a juxtaposed exonic splicing enhancer/exonic splicing silencer element to regulate HIV-1 tat exon 2 splicing. J Biol Chem (2003) 1.56

Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J Virol (1993) 1.44

The PKC gene module: molecular biosystematics to resolve its T cell functions. Immunol Rev (2003) 1.42

Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction. Biochem J (2002) 1.41

Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J Pharmacol Exp Ther (2007) 1.37

Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. IUBMB Life (2001) 1.37

Dual role of HIV Tat in regulation of apoptosis in T cells. J Immunol (1997) 1.25

Regulation of HIV-1 gene expression by the transactivator protein Tat. Curr Top Microbiol Immunol (1995) 1.19

Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway. J Biol Chem (2000) 1.17

Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes. Mol Cell (2011) 1.15

Mechanisms of CD4 T-cell depletion triggered by HIV-1 viral proteins. AIDS Rev (2007) 1.10

Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR. J Virol (1999) 1.07

Regulation of PKC-θ function by phosphorylation in T cell receptor signaling. Front Immunol (2012) 1.06

Signaling through the P38 and ERK pathways: a common link between HIV replication and the immune response. Immunol Res (2010) 1.04

Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction. Cell Immunol (1999) 1.00

To kill or be killed: how HIV exhausts the immune system. Cell Death Differ (2005) 0.99

Functional quantification of DNA-binding proteins p53 and estrogen receptor in cells and tumor tissues by DNA affinity immunoblotting. Cancer Res (2001) 0.98

Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1. Mol Biol Cell (2006) 0.95

Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon. Nucleic Acids Res (2010) 0.94

Extracellular HIV-1 Tat protein differentially activates the JNK and ERK/MAPK pathways in CD4 T cells. AIDS (1999) 0.92

New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C. Stem Cells (1998) 0.89

Expression of IkappaBalpha in the nucleus of human peripheral blood T lymphocytes. Oncogene (1999) 0.86

Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes. J Biol Chem (2011) 0.84

Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells. J Immunol (2008) 0.84

The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral production. J Biol Chem (2013) 0.83

Analysis of protein kinase C theta inhibitors for the control of HIV-1 replication in human CD4+ T cells reveals an effect on retrotranscription in addition to viral transcription. Biochem Pharmacol (2015) 0.79

Articles by these authors

PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation. Front Immunol (2015) 0.75