Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26974319)

Published in PLoS One on March 14, 2016

Authors

Xiaoyan Huang1, Zhiying He1, Xinwei Jiang1, Mengjun Hou2, Zhihong Tang2, Xiaozhou Zhen1, Yuming Liang1, Jing Ma1

Author Affiliations

1: Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.
2: Experimental and Teaching Center for public health, School of Public Health, Sun Yat-Sen University, Guangzhou, P. R. China.

Articles cited by this

Inflammation and cancer. Nature (2002) 53.78

Inflammation in atherosclerosis. Nature (2002) 28.92

Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (2001) 23.83

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol (1996) 15.20

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem (1994) 14.36

HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12

Interleukin-1 and interleukin-1 antagonism. Blood (1991) 7.67

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell (2001) 4.75

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med (2001) 3.87

Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. Nat Rev Immunol (2005) 3.21

Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J (2006) 2.13

Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J Clin Invest (1994) 2.09

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. J Biol Chem (2003) 2.00

Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation (2002) 1.98

High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein. Cytokine (2000) 1.92

Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein. Cancer Res (2001) 1.90

PI3K/PTEN signaling in tumorigenesis and angiogenesis. Biochim Biophys Acta (2007) 1.88

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood (2009) 1.70

TNF, immunity and inflammatory disease: lessons of the past decade. J Investig Med (1995) 1.50

Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes. J Neuroinflammation (2007) 1.48

Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol (2006) 1.47

Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells. Cytokine (1991) 1.37

Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase. Cancer Res (2002) 1.35

Identification of a novel small molecule HIF-1alpha translation inhibitor. Clin Cancer Res (2009) 1.33

Folic acid improves arterial endothelial function in adults with hyperhomocystinemia. J Am Coll Cardiol (1999) 1.20

Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration. Immunobiology (2008) 1.18

Folate: a functional food constituent. J Food Sci (2010) 1.07

HIF-1alpha: a valid therapeutic target for tumor therapy. Cancer Res Treat (2004) 1.06

Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. PLoS One (2011) 1.05

PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CA9 and VEGF, in human cancer cell lines. Cancer Lett (2009) 1.04

Macrophage activation by culture in an anoxic environment. J Immunol (1995) 1.03

The history of folic acid. Br J Haematol (2001) 1.00

Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects. Int J Obes (Lond) (2006) 0.99

Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry. J Cardiovasc Risk (1998) 0.98

Effect of hypoxia and exogenous IL-10 on the pro-inflammatory cytokine TNF-alpha and the anti-angiogenic molecule soluble Flt-1 in placental villous explants. Cytokine (2009) 0.95

An unexpected role for hypoxic response: oxygenation and inflammation. Cell Cycle (2004) 0.94

Hypoxia induces expression of the chemokines monocyte chemoattractant protein-1 (MCP-1) and IL-8 in human dermal fibroblasts. Clin Exp Immunol (2001) 0.93

MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner. J Biol Chem (2014) 0.92

Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7. Biochem Biophys Res Commun (2009) 0.90

Folate status in various pathophysiological conditions. IUBMB Life (2008) 0.89

Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages. Am J Physiol (1999) 0.88

Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7. Shock (2009) 0.86

Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-κB activation. Inflamm Res (2011) 0.85

The contribution of hypoxia-reperfusion injury to inflammatory synovitis: the influence of reactive oxygen intermediates on the transcriptional control of inflammation. Ann N Y Acad Sci (1994) 0.84

Hypoxia-inducible aryl hydrocarbon receptor nuclear translocator (ARNT) (HIF-1β): is it a rare exception? Mol Med (2014) 0.83

Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing. J Mol Med (Berl) (2015) 0.81

Leukocyte responses to hypoxic/ischemic conditions. New Horiz (1996) 0.81

Increased folate intake with no changes in serum homocysteine and decreased levels of C-reactive protein in patients with inflammatory bowel diseases. Dig Dis Sci (2008) 0.80

Altitude and cold weather: are they vascular risks? Curr Opin Cardiol (2014) 0.76