Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 27015814)

Published in J Exp Clin Cancer Res on March 25, 2016

Authors

Laura Mercurio1, Maria Antonietta Ajmone-Cat1, Serena Cecchetti1, Alessandro Ricci1, Giuseppina Bozzuto2, Agnese Molinari2, Isabella Manni3, Bianca Pollo4, Stefania Scala5, Giulia Carpinelli6, Luisa Minghetti7

Author Affiliations

1: Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
2: Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.
3: Department of Research, Diagnosis and Innovative Technologies, Regina Elena National Cancer Institute, Rome, Italy.
4: Division of Neuropathology, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy.
5: Molecular Immunology, Functional Genomics, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale" IRCCS, Napoli, Italy.
6: Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy. giulia.carpinelli@iss.it.
7: Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy. luisa.minghetti@iss.it.

Articles cited by this

Cancer-related inflammation. Nature (2008) 34.21

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med (1989) 7.72

A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43

CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res (2010) 5.42

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood (2005) 5.21

Glioblastoma and other malignant gliomas: a clinical review. JAMA (2013) 4.99

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest (2010) 3.74

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A (2003) 3.72

Roles of nitric oxide in tumor growth. Proc Natl Acad Sci U S A (1995) 3.28

Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. J Neurooncol (2007) 2.85

Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J Natl Cancer Inst (2007) 2.57

Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res (2006) 2.42

The molecular profile of microglia under the influence of glioma. Neuro Oncol (2012) 2.38

CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem (2002) 2.37

Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma. Clin Cancer Res (2005) 2.28

Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection. J Acquir Immune Defic Syndr (2004) 2.21

The brain tumor microenvironment. Glia (2011) 2.13

Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Res (2003) 2.11

AMD3100 is a CXCR7 ligand with allosteric agonist properties. Mol Pharmacol (2009) 1.99

Chemokines and their receptors in the central nervous system. Front Neuroendocrinol (2001) 1.93

Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survival. Neurosurgery (2007) 1.79

Distribution and characterization of microglia/macrophages in human brain tumors. Acta Neuropathol (1996) 1.73

A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection. Semin Immunol (1998) 1.66

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res (2009) 1.64

Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. J Biol Chem (2003) 1.50

Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas. PLoS One (2011) 1.50

CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas. Clin Cancer Res (2006) 1.42

Glioblastoma: therapeutic challenges, what lies ahead. Biochim Biophys Acta (2012) 1.36

The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci (2015) 1.33

Immune surveillance properties of human NK cell-derived exosomes. J Immunol (2012) 1.26

The controversial role of microglia in malignant gliomas. Clin Dev Immunol (2013) 1.11

Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS One (2015) 1.11

Molecular heterogeneity in glioblastoma: potential clinical implications. Front Oncol (2015) 1.06

Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells. Breast Cancer Res (2012) 1.04

Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9. Blood (2013) 1.03

Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats. Neuro Oncol (2013) 1.01

Activation of chemokine receptor CXCR4 in malignant glioma cells promotes the production of vascular endothelial growth factor. Biochem Biophys Res Commun (2005) 0.97

CXCL12 in malignant glial tumors: a possible role in angiogenesis and cross-talk between endothelial and tumoral cells. J Neurooncol (2004) 0.97

Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity. Toxicology (2013) 0.96

Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas. Br J Cancer (2011) 0.96

Molecular Pathways: Targeting the CXCR4-CXCL12 Axis-Untapped Potential in the Tumor Microenvironment. Clin Cancer Res (2015) 0.94

Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia. Glia (2013) 0.93

Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis. PLoS One (2013) 0.93

CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases. Ann Surg Oncol (2011) 0.93

Preclinical development of a novel class of CXCR4 antagonist impairing solid tumors growth and metastases. PLoS One (2013) 0.92

Cytokine patterns in brain tumour progression. Mediators Inflamm (2013) 0.92

CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells. Cell Death Dis (2014) 0.92

Cancer cell metabolism and the modulating effects of nitric oxide. Free Radic Biol Med (2014) 0.90

Understanding local macrophage phenotypes in disease: modulating macrophage function to treat cancer. Nat Med (2015) 0.88

The role of CXCR4 in highly malignant human gliomas biology: current knowledge and future directions. Glia (2014) 0.86

Experimental model and immunohistochemical analyses of U87 human glioblastoma cell xenografts in immunosuppressed rat brains. Anticancer Res (2006) 0.85

Targeting chemokine receptor CXCR7 inhibits glioma cell proliferation and mobility. Anticancer Res (2015) 0.84

The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype. J Neuroinflammation (2014) 0.84

A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion. Cancer Lett (2015) 0.83

Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway. Oncotarget (2015) 0.83

CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia. Neuropathol Appl Neurobiol (2013) 0.81

Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons. Neurobiol Dis (2006) 0.79