MET Exon 14 Skipping in Non-Small Cell Lung Cancer.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 27022036)

Published in Oncologist on March 28, 2016

Authors

Rebecca S Heist1, Hyo Sup Shim2, Shalini Gingipally3, Mari Mino-Kenudson4, Long Le4, Justin F Gainor3, Zongli Zheng4, Martin Aryee4, Junfeng Xia5, Peilin Jia6, Hailing Jin7, Zhongming Zhao8, William Pao7, Jeffrey A Engelman3, A John Iafrate4

Author Affiliations

1: Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA rheist@partners.org.
2: Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA Department of Pathology, College of Medicine, Yonsei University, Seoul, Republic of Korea.
3: Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
4: Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
5: Institute of Health Sciences, Anhui University, Hefei, Anhui, People's Republic of China Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
6: Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
7: Division of Hematology-Oncology, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
8: Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA Center for Precision Health, School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, USA.

Articles cited by this

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med (2004) 71.08

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (2004) 61.56

Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med (2009) 46.35

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature (2007) 37.09

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med (2010) 36.78

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A (2004) 33.85

Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02

Comprehensive genomic characterization of squamous cell lung cancers. Nature (2012) 18.90

Comprehensive molecular profiling of lung adenocarcinoma. Nature (2014) 11.02

Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med (2014) 9.94

Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med (2014) 6.95

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. EMBO Mol Med (2010) 6.38

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res (2005) 4.13

The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res (2012) 3.80

Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol (2011) 3.55

Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res (2006) 3.12

Anchored multiplex PCR for targeted next-generation sequencing. Nat Med (2014) 2.25

Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discov (2015) 1.91

Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol (2009) 1.81

Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Cancer Discov (2015) 1.67

MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol (2011) 1.29

MET Exon 14 Mutations in Non-Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression. J Clin Oncol (2016) 1.27

Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations. J Clin Oncol (2015) 1.26

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation. Clin Lung Cancer (2015) 0.93

Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells. J Thorac Oncol (2010) 0.93

MET Mutation Associated with Responsiveness to Crizotinib. J Thorac Oncol (2015) 0.87

MET-Mutated NSCLC with Major Response to Crizotinib. J Thorac Oncol (2015) 0.86