Published in Front Cell Infect Microbiol on March 23, 2016
The Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious Toxin. Front Cell Infect Microbiol (2016) 0.78
Impact of CDT Toxin on Human Diseases. Toxins (Basel) (2016) 0.78
Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms. Sci Rep (2016) 0.75
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections. Front Cell Infect Microbiol (2017) 0.75
Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells. Sci Rep (2017) 0.75
Cancer associated faecal microbial markers in colorectal cancer detection. Int J Cancer (2017) 0.75
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer (2006) 8.83
Intestinal inflammation targets cancer-inducing activity of the microbiota. Science (2012) 7.54
A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science (2000) 5.31
The ABC of APC. Hum Mol Genet (2001) 4.16
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci U S A (2002) 3.57
DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest. Mol Microbiol (2000) 3.20
A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase. Mol Microbiol (1997) 2.54
Association between intraepithelial Escherichia coli and colorectal cancer. Gastroenterology (1998) 2.15
Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Trends Biochem Sci (2000) 1.85
Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun (2004) 1.74
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology (2009) 1.72
High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer. PLoS One (2013) 1.50
Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells. Infect Immun (1999) 1.48
Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages. Microbiology (2011) 1.40
Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol (2007) 1.32
The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA. Cell Microbiol (2003) 1.31
In vivo virulence properties of bacterial cytolethal-distending toxin. Cell Microbiol (2008) 1.29
Genetic and epigenetic events generate multiple pathways in colorectal cancer progression. Patholog Res Int (2012) 1.24
A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity. J Immunol (2007) 1.16
Colonization of the human gut by E. coli and colorectal cancer risk. Clin Cancer Res (2013) 1.12
The physiology of phosphoinositides. Biol Pharm Bull (2007) 1.08
Chronic exposure to the cytolethal distending toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response. Cell Microbiol (2012) 1.00
Emerging roles of the microbiome in cancer. Carcinogenesis (2013) 1.00
Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling. J Cell Mol Med (2009) 1.00
Fusobacterium and Enterobacteriaceae: important players for CRC? Immunol Lett (2014) 0.98
Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up. Radiother Oncol (2013) 0.97
Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair. Biochemistry (2006) 0.97
Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth. Cancer Res (2011) 0.94
From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin. Cell Microbiol (2012) 0.90
APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation. Development (2013) 0.88
Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts. DNA Repair (Amst) (2014) 0.88
The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective. Cells (2014) 0.85
Breaking the Gingival Epithelial Barrier: Role of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin in Oral Infectious Disease. Cells (2014) 0.83
The toxicity of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity. Cell Microbiol (2015) 0.81
Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. Cell Physiol Biochem (2015) 0.80
Gut Microbiota and Colorectal Cancer. Gastrointest Tumors (2015) 0.80
Genotoxicity of pesticide mixtures present in the diet of the French population. Environ Mol Mutagen (2012) 0.79
Activated K-RAS and its effect on morphological appearance. J Biochem (2014) 0.78
Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis. Life Sci (2015) 0.77