Published in Biol Pharm Bull on September 01, 2007
Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol (2009) 5.83
Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. J Biol Chem (2008) 2.30
ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death. Autophagy (2008) 1.87
Development of a unique small molecule modulator of CXCR4. PLoS One (2012) 1.18
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. PLoS One (2013) 1.00
Membrane trafficking and phagosome maturation during the clearance of apoptotic cells. Int Rev Cell Mol Biol (2012) 0.86
Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase. Mol Immunol (2010) 0.83
Whole genome association study identifies regions of the bovine genome and biological pathways involved in carcass trait performance in Holstein-Friesian cattle. BMC Genomics (2014) 0.81
Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. Cell Physiol Biochem (2015) 0.80
Effect of PIP3 on adhesion molecules and adhesion of THP-1 monocytes to HUVEC treated with high glucose. Cell Physiol Biochem (2014) 0.79
The Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious Toxin. Front Cell Infect Microbiol (2016) 0.78
Sorting nexin 19 regulates the number of dense core vesicles in pancreatic β-cells. J Diabetes Investig (2012) 0.77
Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis. Front Cell Infect Microbiol (2016) 0.77
Biochemical and phylogenetic analyses of phosphatidylinositol production in Angomonas deanei, an endosymbiont-harboring trypanosomatid. Parasit Vectors (2015) 0.77
Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate. Mol Oral Microbiol (2015) 0.76
Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge. PLoS One (2014) 0.76
A Journey of Cytolethal Distending Toxins through Cell Membranes. Front Cell Infect Microbiol (2016) 0.75
PIP3 but not PIP2 increases GLUT4 surface expression and glucose metabolism mediated by AKT/PKCζ/λ phosphorylation in 3T3L1 adipocytes. Mol Cell Biochem (2013) 0.75
Cell Polarity in Cerebral Cortex Development-Cellular Architecture Shaped by Biochemical Networks. Front Cell Neurosci (2017) 0.75
Orangutan cultures and the evolution of material culture. Science (2003) 6.06
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res (2011) 6.02
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
Nitrogen uptake, assimilation and remobilization in plants: challenges for sustainable and productive agriculture. Ann Bot (2010) 3.11
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science (2009) 2.23
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Major issues and challenges of influenza pandemic preparedness in developing countries. Emerg Infect Dis (2008) 2.16
High prevalence of obstructive sleep apnea and its association with renal function among nondialysis chronic kidney disease patients in Japan: a cross-sectional study. Clin J Am Soc Nephrol (2011) 1.98
Enterovirus 68 among children with severe acute respiratory infection, the Philippines. Emerg Infect Dis (2011) 1.96
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (2003) 1.80
Retracted Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice. Nat Med (2004) 1.69
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc Natl Acad Sci U S A (2004) 1.67
Anterior paraclinoid aneurysms. J Neurosurg (2002) 1.59
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res (2009) 1.48
Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits. Genome Res (2008) 1.46
Mechanism of beta 1-integrin-mediated hepatoma cell growth involves p27 and S-phase kinase-associated protein 2. Hepatology (2003) 1.45
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab (2007) 1.39
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco. Plant Physiol (2006) 1.37
Physiological functions of Pten in mouse tissues. Cell Struct Funct (2003) 1.36
Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. J Biol Chem (2003) 1.34
Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. Hepatol Res (2005) 1.32
Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development (2011) 1.30
Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res (2006) 1.29
Fukutin is required for maintenance of muscle integrity, cortical histiogenesis and normal eye development. Hum Mol Genet (2003) 1.27
Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. J Bone Miner Res (2008) 1.25
Large-scale sequence analysis of M gene of influenza A viruses from different species: mechanisms for emergence and spread of amantadine resistance. Antimicrob Agents Chemother (2009) 1.24
Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries. Virol J (2010) 1.23
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Mol Cell Biol (2006) 1.21
The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature (2010) 1.21
Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res (2008) 1.19
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A (2011) 1.18
PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nat Commun (2012) 1.18
Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis. Virol J (2009) 1.18
NaCl stress effects on enzymes involved in nitrogen assimilation pathway in tomato "Lycopersicon esculentum" seedlings. J Plant Physiol (2005) 1.17
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16
Detection of human rhinovirus C viral genome in blood among children with severe respiratory infections in the Philippines. PLoS One (2011) 1.15
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol (2006) 1.12
Detection of non-polio enteroviruses from 17 years of virological surveillance of acute flaccid paralysis in the Philippines. J Med Virol (2012) 1.12
Antigenic and receptor binding properties of enterovirus 68. J Virol (2013) 1.11
Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem (2003) 1.11
Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem (2013) 1.10
Hematopoietic and nonhematopoietic potentials of Hoechst(low)/side population cells isolated from adult rat kidney. Kidney Int (2004) 1.10
Common mutations F310L and T1559del in the tissue-nonspecific alkaline phosphatase gene are related to distinct phenotypes in Japanese patients with hypophosphatasia. Eur J Pediatr (2005) 1.10
Cadmium toxicity induced changes in nitrogen management in Lycopersicon esculentum leading to a metabolic safeguard through an amino acid storage strategy. Plant Cell Physiol (2004) 1.09
Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity. Am J Respir Crit Care Med (2012) 1.07
3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc Natl Acad Sci U S A (2012) 1.07
Comparison of selection pressures on the HA gene of pandemic (2009) and seasonal human and swine influenza A H1 subtype viruses. Virology (2010) 1.05
Leifsonia gen. nov., a genus for 2,4-diaminobutyric acid-containing actinomycetes to accommodate "Corynebacterium aquaticum" Leifson 1962 and Clavibacter xyli subsp. cynodontis Davis et al. 1984. J Gen Appl Microbiol (1999) 1.05
The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS One (2011) 1.05
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc Natl Acad Sci U S A (2008) 1.04
Hypomagnesemia in type 2 diabetic nephropathy: a novel predictor of end-stage renal disease. Diabetes Care (2012) 1.03
Comparison of orthodontic and orthopedic effects of a modified maxillary protractor between deciduous and early mixed dentitions. Am J Orthod Dentofacial Orthop (2004) 1.03
Simultaneous microscopic and endoscopic monitoring during surgery for internal carotid artery aneurysms. J Neurosurg (2004) 1.02
Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season. J Clin Microbiol (2008) 1.02
Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt. Biochem J (2005) 1.02
Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype. PLoS One (2010) 1.02
Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration. Eur J Biochem (2002) 1.01
Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem (2010) 1.01
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood (2006) 1.00
Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis. Cancer Res (2002) 1.00
Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J Hepatol (2008) 1.00
Effects of fukutin deficiency in the developing mouse brain. Neuromuscul Disord (2005) 0.99
Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol Res (2006) 0.99
Capturing the mammalian Hippo: elucidating its role in cancer. Cancer Sci (2013) 0.97
Clinicopathologic features and histochemical analyses of proliferative activity and angiogenesis in small cell carcinoma of the esophagus. J Gastroenterol (2007) 0.97
Association between serum C-reactive protein levels and microalbuminuria: a population-based cross-sectional study in northern Iwate, Japan. Intern Med (2004) 0.96
Resolving the role of plant glutamate dehydrogenase. I. In vivo real time nuclear magnetic resonance spectroscopy experiments. Plant Cell Physiol (2009) 0.96
Diffusion changes in a tumor and peritumoral tissue after stereotactic irradiation for brain tumors: possible prediction of treatment response. J Comput Assist Tomogr (2006) 0.95
Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes. Diabetes (2010) 0.95
Amino acid pattern and glutamate metabolism during dehydration stress in the 'resurrection' plant Sporobolus stapfianus: a comparison between desiccation-sensitive and desiccation-tolerant leaves. J Exp Bot (2007) 0.95
Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J Biochem (2002) 0.95
Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism. J Immunol (2008) 0.95
Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues. J Mater Sci Mater Med (2007) 0.94
Effect of collimator choice on quantitative assessment of cardiac iodine 123 MIBG uptake. J Nucl Cardiol (2003) 0.94
Occurrence of mixed populations of influenza A viruses that can be maintained through transmission in a single host and potential for reassortment. J Clin Microbiol (2009) 0.93
Beta 1-integrin protects hepatoma cells from chemotherapy induced apoptosis via a mitogen-activated protein kinase dependent pathway. Cancer (2002) 0.93
Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. J Gastroenterol Hepatol (2007) 0.93