Clinical activity of carfilzomib correlates with inhibition of multiple proteasome subunits: application of a novel pharmacodynamic assay.

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🔗 View Article (PMID 27071340)

Published in Br J Haematol on April 12, 2016

Authors

Susan J Lee1, Konstantin Levitsky1, Francesco Parlati1, Mark K Bennett1, Shirin Arastu-Kapur1, Lois Kellerman1, Tina F Woo1, Alvin F Wong1, Kyriakos P Papadopoulos2, Ruben Niesvizky3, Ashraf Z Badros4, Ravi Vij5, Sundar Jagannath6, David Siegel7, Michael Wang8, Gregory J Ahmann9, Christopher J Kirk1

Author Affiliations

1: Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA.
2: South Texas Accelerated Research Therapeutics (START), San Antonio, TX, USA.
3: New York Presbyterian Hospital-Cornell Medical Center, New York, NY, USA.
4: Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA.
5: Washington University School of Medicine, St Louis, MO, USA.
6: St. Vincent's Comprehensive Cancer Center, New York, NY, USA.
7: Hackensack University Medical Center, Hackensack, NJ, USA.
8: Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
9: Mayo Clinic Arizona, Scottsdale, AZ, USA.

Associated clinical trials:

Phase 2 Study of Carfilzomib in Relapsed and Refractory Multiple Myeloma | NCT00511238

Phase 2 Study of Carfilzomib in Relapsed Multiple Myeloma | NCT00530816

Phase 1b Multicenter Study of Carfilzomib With Lenalidomide and Dexamethasone in Relapsed Multiple Myeloma | NCT00603447

Study of the Safety and Pharmacokinetics of Carfilzomib in Patients With Relapsed and Refractory Multiple Myeloma and Varying Degrees of Renal Function | NCT00721734

Phase 1b/2 Study of Carfilzomib in Relapsed Solid Tumors, Multiple Myeloma, or Lymphoma | NCT00531284

Carfilzomib, Cyclophosphamide, Dexamethasone in Multiple Myeloma | NCT03336073

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