Published in Osteoarthritis Cartilage on April 12, 2016
A Study of FolateScan in Patients With Knee Osteoarthritis | NCT01237405
Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity. Arthritis Rheumatol (2017) 0.81
Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases. Immune Netw (2016) 0.75
Osteoarthritis: Molecular imaging detects activated macrophages. Nat Rev Rheumatol (2016) 0.75
Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation. Osteoarthritis Cartilage (2016) 0.75
Serum interleukin 6 levels are associated with depressive state of the patients with knee osteoarthritis irrespective of disease severity. Clin Rheumatol (2017) 0.75
Innate Immune Responses and Osteoarthritis. Curr Rheumatol Rep (2017) 0.75
Radiological assessment of osteo-arthrosis. Ann Rheum Dis (1957) 42.98
An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics (1977) 9.41
Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthritis Cartilage (2007) 4.69
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest (2011) 3.69
Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc Chem Res (2007) 3.03
Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage (2005) 2.69
Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage (2012) 2.62
Macrophages are required for adult salamander limb regeneration. Proc Natl Acad Sci U S A (2013) 2.07
The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther (2006) 1.93
Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients. Arthritis Rheum (2009) 1.77
Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. Cancer Res (2009) 1.71
Obesity and osteoarthritis of the knee: evidence from the National Health and Nutrition Examination Survey (NHANES I). Semin Arthritis Rheum (1990) 1.65
Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study. Ann Rheum Dis (2011) 1.63
Musculoskeletal disease research: should we analyze the joint or the person? J Rheumatol (1996) 1.63
The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis Rheum (2010) 1.63
Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years. Arthritis Rheum (2004) 1.59
Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev (2004) 1.58
Features of the dendritic cell lineage. Immunol Rev (2010) 1.58
A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood (2008) 1.49
Synthesis and biological evaluation of EC20: a new folate-derived, (99m)Tc-based radiopharmaceutical. Bioconjug Chem (2002) 1.48
Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum (1999) 1.43
Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep (2013) 1.31
Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum (2002) 1.30
Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets. Curr Drug Targets (2007) 1.18
Magnetic resonance imaging and ultrasonographic evaluation of the patients with knee osteoarthritis: a comparative study. Clin Rheumatol (2003) 1.05
Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis. Arthritis Rheumatol (2015) 1.04
Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate. Arthritis Res Ther (2011) 1.03
An emerging player in knee osteoarthritis: the infrapatellar fat pad. Arthritis Res Ther (2013) 1.03
Assessment of disease activity in rheumatoid arthritis using a novel folate targeted radiopharmaceutical Folatescan. Clin Exp Rheumatol (2009) 1.02
Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles. Scand J Rheumatol (2012) 1.02
Optimization of the fixed-flexion knee radiograph. Osteoarthritis Cartilage (2007) 1.01
Knee osteoarthritis. Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging. Ann Rheum Dis (2008) 0.97
A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity. Arthritis Res Ther (2011) 0.95
Clinical translation of folate receptor-targeted therapeutics. Expert Opin Drug Deliv (2012) 0.92
Imaging the folate receptor on cancer cells with 99mTc-etarfolatide: properties, clinical use, and future potential of folate receptor imaging. J Nucl Med (2014) 0.91
The history of osteoarthritis-osteoarthrosis. Ann Rheum Dis (2008) 0.89
Use of folate-conjugated imaging agents to target alternatively activated macrophages in a murine model of asthma. Mol Pharm (2013) 0.89
Folate receptor-β imaging using 99mTc-folate to explore distribution of polarized macrophage populations in human atherosclerotic plaque. J Nucl Med (2014) 0.89
Folate-targeted hapten immunotherapy of adjuvant-induced arthritis: comparison of hapten potencies. Mol Pharm (2009) 0.86
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr (2014) 0.85
Folic acid-functionalized human serum albumin nanocapsules for targeted drug delivery to chronically activated macrophages. Int J Pharm (2012) 0.84
Prediction of Response to Therapy for Autoimmune/Inflammatory Diseases Using an Activated Macrophage-Targeted Radioimaging Agent. Mol Pharm (2015) 0.81
A Systematic Approach to Identify Markers of Distinctly Activated Human Macrophages. Front Immunol (2015) 0.80
Inflammatory ultrasound features show independent associations with progression of structural damage after over 2 years of follow-up in patients with hand osteoarthritis. Ann Rheum Dis (2014) 0.80
Follow-up study of inflammatory ultrasound features in hand osteoarthritis over a period of 3 months: variable as well as constant. Osteoarthritis Cartilage (2013) 0.78
Inflammatory biomarkers in osteoarthritis. Osteoarthritis Cartilage (2015) 0.84
Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation. Osteoarthritis Cartilage (2016) 0.77