IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty.

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Published in EMBO Mol Med on June 01, 2016

Authors

Sasha R Howard1, Leonardo Guasti1, Gerard Ruiz-Babot1, Alessandra Mancini1, Alessia David2, Helen L Storr1, Lousie A Metherell1, Michael Je Sternberg2, Claudia P Cabrera3, Helen R Warren4, Michael R Barnes3, Richard Quinton5, Nicolas de Roux6, Jacques Young7, Anne Guiochon-Mantel8, Karoliina Wehkalampi9, Valentina André10, Yoav Gothilf11, Anna Cariboni12, Leo Dunkel13

Author Affiliations

1: Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
2: Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London, UK.
3: Centre for Translational Bioinformatics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
4: NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK.
5: Institute of Genetic Medicine University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, UK.
6: Unité Mixte de Recherche 1141, Institut National de la Santé et de la Recherche Médicale, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Hôpital Robert Debré, Paris, France Laboratoire de Biochimie, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris, France.
7: Univ Paris-Sud, Le Kremlin Bicêtre, France INSERM UMR-1185, Le Kremlin Bicêtre, France Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France Department of Reproductive Endocrinology, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
8: Univ Paris-Sud, Le Kremlin Bicêtre, France INSERM UMR-1185, Le Kremlin Bicêtre, France Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
9: Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
10: Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
11: Department of Neurobiology, The George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel.
12: Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy Institute of Ophthalmology, University College London (UCL), London, UK.
13: Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK l.dunkel@qmul.ac.uk.

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