Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC.

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Published in Oncoimmunology on August 12, 2015

Authors

Benjamin Besse1, Mélinda Charrier2, Valérie Lapierre3, Eric Dansin4, Olivier Lantz5, David Planchard6, Thierry Le Chevalier6, Alain Livartoski7, Fabrice Barlesi8, Agnès Laplanche9, Stéphanie Ploix10, Nadège Vimond11, Isabelle Peguillet5, Clotilde Théry12, Ludovic Lacroix13, Inka Zoernig14, Kavita Dhodapkar15, Madhav Dhodapkar16, Sophie Viaud17, Jean-Charles Soria18, Katrin S Reiners19, Elke Pogge von Strandmann19, Frédéric Vély20, Sylvie Rusakiewicz21, Alexander Eggermont17, Jonathan M Pitt17, Laurence Zitvogel22, Nathalie Chaput23

Author Affiliations

1: Gustave Roussy Cancer Campus, Villejuif, France; Département de Médecine Oncologique (Unité thorax), Gustave Roussy Cancer Campus, Villejuif, France; Faculté de médecine, Université Paris Sud, Le Kremlin-Bicêtre, France.
2: Gustave Roussy Cancer Campus, Villejuif, France; Faculté de médecine, Université Paris Sud, Le Kremlin-Bicêtre, France; Laboratoire d'Immunomonitoring en Oncologie, UMS 3655 CNRS / US 23 INSERM Gustave Roussy Cancer Campus, Villejuif, France; Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France.
3: Gustave Roussy Cancer Campus, Villejuif, France; Laboratoire de Thérapie Cellulaire, Gustave Roussy Cancer Campus, Villejuif, France.
4: Département d'oncologie générale, CLCC Oscar Lambret , Lille, France.
5: Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France; Laboratoire d'Immunologie Clinique, Institut Curie, Paris, France; Inserm U932, Institut Curie, Paris, France.
6: Département de Médecine Oncologique (Unité thorax), Gustave Roussy Cancer Campus , Villejuif, France.
7: Institut Curie, Département de médecine oncologique , Paris, France.
8: Service d'Oncologie Multidisciplinaire & Innovations Thérapeutiques, Université Aix Marseille, Assistance Publique Hôpitaux de Marseille , Marseille, France.
9: Département de Biostatistique et d'épidémiologie, Gustave Roussy Cancer Campus , Villejuif, France.
10: Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France.
11: Laboratoire d'Immunomonitoring en Oncologie, UMS 3655 CNRS / US 23 INSERM Gustave Roussy Cancer Campus, Villejuif, France; Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France.
12: Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France; Inserm U932, Institut Curie, Paris, France.
13: Département de biologie et pathologie médicale, Gustave Roussy Cancer Campus, Villejuif, France; Laboratoire de Recherche Translationnelle, UMS 3655 CNRS / US 23 INSERM Gustave Roussy Cancer Campus, Villejuif, France.
14: Department of Medical Oncology, National Center for Tumor Diseases (NCT) and Heidelberg University Hospital , Heidelberg, Germany.
15: Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, CT, USA; Yale Cancer Center, Yale School of Medicine, Yale University, New Haven, CT, USA.
16: Yale Cancer Center, Yale School of Medicine, Yale University, New Haven, CT, USA; Department of Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA; Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, USA.
17: Gustave Roussy Cancer Campus, Villejuif, France; Faculté de médecine, Université Paris Sud, Le Kremlin-Bicêtre, France; INSERM, U1015, Villejuif, France.
18: Gustave Roussy Cancer Campus, Villejuif, France; Faculté de médecine, Université Paris Sud, Le Kremlin-Bicêtre, France; INSERM, U981, Villejuif, France; Département d'Innovation Thérapeutique et d'Essais Précoces, Gustave Roussy Cancer Campus, Villejuif, France.
19: Department of Internal Medicine I, University Hospital of Cologne , Cologne, Germany.
20: Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, Case 906, France; INSERM, U1104, Marseille, France; CNRS, UMR7280, Marseille, France; Laboratoire d'immunologie- Hôpital de la Conception, Assistance Publique - Hôpitaux de Marseille, Marseille, France.
21: Gustave Roussy Cancer Campus, Villejuif, France; Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France; INSERM, U1015, Villejuif, France.
22: Gustave Roussy Cancer Campus, Villejuif, France; Faculté de médecine, Université Paris Sud, Le Kremlin-Bicêtre, France; Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France; INSERM, U1015, Villejuif, France.
23: Gustave Roussy Cancer Campus, Villejuif, France; Laboratoire d'Immunomonitoring en Oncologie, UMS 3655 CNRS / US 23 INSERM Gustave Roussy Cancer Campus, Villejuif, France; Centre d'Investigation Clinique en Biothérapies (CICBT) 1428, Villejuif, France; Laboratoire de Thérapie Cellulaire, Gustave Roussy Cancer Campus, Villejuif, France.

Associated clinical trials:

Trial of a Vaccination With Tumor Antigen-loaded Dendritic Cell-derived Exosomes (CSET 1437) | NCT01159288

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