Published in EMBO J on March 01, 2001
Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci (2005) 9.75
From the cradle to the grave: molecular chaperones that may choose between folding and degradation. EMBO Rep (2001) 2.55
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev (2007) 2.32
A comprehensive analysis of hydrogen peroxide-induced gene expression in tobacco. Proc Natl Acad Sci U S A (2003) 1.92
A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Mol Cell (2011) 1.81
Membrane protein insertion at the endoplasmic reticulum. Annu Rev Cell Dev Biol (2011) 1.74
Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function. PLoS One (2008) 1.63
Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC. Oncoimmunology (2015) 1.53
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med (2012) 1.48
The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol Cell Biol (2005) 1.39
Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal (2011) 1.37
Spatial and temporal changes in Bax subcellular localization during anoikis. J Cell Biol (2003) 1.34
Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell (2003) 1.32
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions. Cell Stress Chaperones (2003) 1.27
Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. Mol Cell Biol (2006) 1.12
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci (2005) 1.10
Molecular chaperones as rational drug targets for Parkinson's disease therapeutics. CNS Neurol Disord Drug Targets (2010) 1.04
BAG3: a new player in the heart failure paradigm. Heart Fail Rev (2015) 0.98
Phenotype-based identification of host genes required for replication of African swine fever virus. J Virol (2006) 0.96
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis. J Cell Biol (2008) 0.92
Scythe regulates apoptosis through modulating ubiquitin-mediated proteolysis of the Xenopus elongation factor XEF1AO. Biochem J (2007) 0.90
Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach. J Proteome Res (2010) 0.90
Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis. BMC Cancer (2013) 0.88
A novel BAT3 sequence generated by alternative RNA splicing of exon 11B displays cell type-specific expression and impacts on subcellular localization. PLoS One (2012) 0.87
BAT3 interacts with transforming growth factor-beta (TGF-beta) receptors and enhances TGF-beta1-induced type I collagen expression in mesangial cells. J Biol Chem (2008) 0.85
Drosophila starvin encodes a tissue-specific BAG-domain protein required for larval food uptake. Genetics (2005) 0.85
The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome. PLoS One (2009) 0.85
Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. Proc Natl Acad Sci U S A (2014) 0.84
A novel interaction between CCaMK and a protein containing the Scythe_N ubiquitin-like domain in Lotus japonicus. Plant Physiol (2011) 0.83
A soluble fragment of the tumor antigen BCL2-associated athanogene 6 (BAG-6) is essential and sufficient for inhibition of NKp30 receptor-dependent cytotoxicity of natural killer cells. J Biol Chem (2013) 0.81
Cancer-derived extracellular vesicles: friend and foe of tumour immunosurveillance. Philos Trans R Soc Lond B Biol Sci (2018) 0.80
RIG-I activation induces the release of extracellular vesicles with antitumor activity. Oncoimmunology (2016) 0.79
The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition. Asian J Androl (2015) 0.78
Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis. J Biol Chem (2015) 0.77
HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling. Cell Death Dis (2011) 0.75
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
The Bcl-2 protein family: arbiters of cell survival. Science (1998) 16.08
Molecular chaperones in cellular protein folding. Nature (1996) 14.00
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature (1999) 8.70
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol (1999) 6.58
Genetic control of programmed cell death in Drosophila. Science (1994) 6.08
GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J (1997) 4.68
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell (1995) 4.53
Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. Cell (1995) 3.99
The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. EMBO J (1996) 3.23
Cell killing by the Drosophila gene reaper. Science (1996) 3.11
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem (1999) 2.97
BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91
Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40. J Biol Chem (1996) 2.83
The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. J Biol Chem (2000) 2.66
Interaction of Hsp70 chaperones with substrates. Nat Struct Biol (1997) 2.26
BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity. J Biol Chem (1997) 2.23
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci U S A (1996) 2.21
HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J (1996) 2.09
The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors. Mol Cell Biol (1998) 2.05
Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol (2001) 1.95
Scythe: a novel reaper-binding apoptotic regulator. EMBO J (1998) 1.77
Partner proteins determine multiple functions of Hsp70. Trends Cell Biol (1995) 1.55
A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc Natl Acad Sci U S A (1995) 1.50
BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J (1998) 1.48
Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol (2000) 1.41
Reaper-induced apoptosis in a vertebrate system. EMBO J (1997) 1.40
A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. FEBS Lett (2000) 1.39
Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs). J Biol Chem (1998) 1.24
Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones. J Biol Chem (1998) 1.23
Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function. J Biol Chem (2000) 1.22
Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity. EMBO J (1999) 1.15
Purification and biochemical properties of soluble recombinant human Bax. Protein Expr Purif (1998) 1.04
The universe of Drosophila genes. Science (2000) 0.85
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA (2001) 7.15
Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proc Natl Acad Sci U S A (1985) 6.45
Guided medication dosing for inpatients with renal insufficiency. JAMA (2001) 6.25
Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J Virol (1993) 6.11
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol (2000) 5.24
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol (1993) 5.11
Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst (2000) 4.54
Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites. Mol Biol Cell (1996) 4.37
HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell (1995) 4.25
Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol. J Natl Cancer Inst (2001) 3.88
Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev (1998) 3.72
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Mol Cell Biol (1988) 3.42
Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci U S A (1986) 3.27
The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. EMBO J (1996) 3.23
Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO J (1995) 3.22
OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity (2001) 3.08
The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev (1992) 3.04
Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev (1991) 2.95
BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91
Effect of sodium salicylate on the human heat shock response. Science (1992) 2.88
Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. Genes Dev (1998) 2.84
Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23. Science (1996) 2.84
Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol (1996) 2.83
Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci U S A (1986) 2.83
Association of the polyomavirus middle-T antigen with c-yes protein. Nature (1987) 2.78
Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Mol Cell Biol (1987) 2.77
Transcription of the human hsp70 gene is induced by serum stimulation. Proc Natl Acad Sci U S A (1985) 2.76
Localization of endoplasmic reticulum in living and glutaraldehyde-fixed cells with fluorescent dyes. Cell (1984) 2.73
Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation (2001) 2.70
The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol (2000) 2.69
Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2000) 2.63
Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol (1996) 2.53
Complex regulation of heat shock- and glucose-responsive genes in human cells. Mol Cell Biol (1988) 2.40
Local and nonlocal curvature elasticity in bilayer membranes by tether formation from lecithin vesicles. Biophys J (1992) 2.34
Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol (1997) 2.32
Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. EMBO J (1999) 2.29
In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proc Natl Acad Sci U S A (1990) 2.28
The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage (2006) 2.27
Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit). Mol Cell Biol (1996) 2.20
Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Mol Cell Biol (1987) 2.17
Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Mol Cell Biol (1992) 2.14
Retrograde transport of Golgi-localized proteins to the ER. J Cell Biol (1998) 2.08
RCC1, a regulator of mitosis, is essential for DNA replication. Mol Cell Biol (1992) 2.08
Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation (2000) 2.07
The 18-month impact of an emergency room intervention for adolescent female suicide attempters. J Consult Clin Psychol (2000) 2.05
Toward cataloguing all rice genes: large-scale sequencing of randomly chosen rice cDNAs from a callus cDNA library. Plant J (1994) 2.02
Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.99
Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J (2001) 1.97
HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol (1997) 1.96
Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol (2001) 1.95
Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. Mol Cell Biol (1998) 1.92
Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. J Biol Chem (1996) 1.88
Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes Dev (1997) 1.88
Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J Biol Chem (1998) 1.86
E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Mol Cell Biol (1989) 1.83
End-of-life decision making: when patients and surrogates disagree. J Clin Ethics (1999) 1.83
The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene. Mol Cell Biol (1986) 1.81
Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Mol Cell Biol (1993) 1.81
Retrotransposon-related DNA sequences in the centromeres of grass chromosomes. Genetics (1998) 1.80
Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. J Cell Biol (1989) 1.78
Scythe: a novel reaper-binding apoptotic regulator. EMBO J (1998) 1.77
Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes. Mol Cell Biol (1984) 1.76
Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway. Mol Cell Biol (1998) 1.74
Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes Dev (1991) 1.74
Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Mol Cell Biol (1994) 1.71
Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region. Cell (1987) 1.71
Binding of polyomavirus large T antigen to the human hsp70 promoter is not required for trans activation. Mol Cell Biol (1986) 1.68
Arthritis prevalence and activity limitations in older adults. Arthritis Rheum (2001) 1.65
Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting. Mol Cell Biol (1991) 1.65
Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling. J Mol Biol (1999) 1.65
Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors. Biochem Soc Symp (1999) 1.64
The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive. Mol Cell Biol (1995) 1.63
Negative regulation of the heat shock transcriptional response by HSBP1. Genes Dev (1998) 1.61
Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein. Proc Natl Acad Sci U S A (1987) 1.60
Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. J Cell Biol (1999) 1.60
The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development (1999) 1.59
Transformation of chicken embryo fibroblasts and tumor induction by the middle T antigen of polyomavirus carried in an avian retroviral vector. Mol Cell Biol (1986) 1.58
On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J Biol Chem (1997) 1.57
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. Mol Microbiol (2001) 1.56
High-yield expression and functional analysis of Escherichia coli glycerol-3-phosphate transporter. Biochemistry (2001) 1.56
Vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins. Cell Motil Cytoskeleton (2001) 1.55
Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG. Mol Microbiol (2001) 1.53
The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. J Virol (1997) 1.52
Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biol Reprod (1994) 1.51
Cloning and subcellular localization of human mitochondrial hsp70. J Biol Chem (1995) 1.50
p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells. Genes Dev (1998) 1.50
Phosphatidylinositol kinase type I activity associates with various oncogene products. Oncogene Res (1989) 1.48
Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Mol Cell Biol (1990) 1.48
BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J (1998) 1.48
The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. EMBO J (1998) 1.47
Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element. Mol Cell Biol (1993) 1.47
Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity. Mol Cell Biol (1994) 1.45
The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra. Acta Physiol (Oxf) (2014) 1.44
Requirement of the prolyl isomerase Pin1 for the replication checkpoint. Science (2000) 1.43
The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. J Biol Chem (1999) 1.43
Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. Circulation (2000) 1.43