Published in Sci Rep on May 11, 2016
Differential Impacts of Alternative Splicing Networks on Apoptosis. Int J Mol Sci (2016) 0.75
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 28.73
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med (2000) 9.78
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science (1994) 6.65
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol (2006) 6.22
Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J (1994) 5.69
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med (1994) 5.20
A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42
Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol (2002) 4.36
Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat Med (1997) 4.03
The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol (1999) 3.81
Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J Immunol (2008) 3.11
The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med (1996) 2.99
IL-15 promotes the survival of naive and memory phenotype CD8+ T cells. J Immunol (2003) 2.28
IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity (1996) 2.23
IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood (2003) 2.20
Requirement for IRF-1 in the microenvironment supporting development of natural killer cells. Nature (1998) 2.17
Consequences of regulated pre-mRNA splicing in the immune system. Nat Rev Immunol (2004) 2.13
IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol (1995) 2.10
IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2. J Leukoc Biol (1995) 1.84
Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J Immunol (1998) 1.81
Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15. Blood (1999) 1.71
Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression. Proc Natl Acad Sci U S A (2004) 1.68
Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression. J Neurosci Res (2006) 1.60
The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control. J Immunol (1998) 1.60
Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proc Natl Acad Sci U S A (1996) 1.51
IL-15 availability conditions homeostasis of peripheral natural killer T cells. Proc Natl Acad Sci U S A (2003) 1.45
IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J Immunol (2000) 1.45
T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression. Exp Neurol (2006) 1.30
Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? J Immunol (2000) 1.29
Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes. Proc Natl Acad Sci U S A (2009) 1.28
Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J Immunol (1997) 1.24
Role of IL-15, IL-2, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis. J Immunol (1996) 1.21
Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis. J Neuroimmunol (2010) 1.20
Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis. J Pathol (1997) 1.16
Viral activation of interleukin-15 (IL-15): characterization of a virus-inducible element in the IL-15 promoter region. J Virol (2000) 1.12
The NF-kappaB binding site is essential for transcriptional activation of the IL-15 gene. Immunogenetics (1998) 1.10
Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type I. Mol Ther (2010) 1.08
Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple sclerosis. J Immunol (2010) 1.07
IL-15 is elevated in serum and cerebrospinal fluid of patients with multiple sclerosis. J Neurol Sci (2005) 1.04
Neuropathobiology of multiple sclerosis. Neurol Clin (2005) 1.04
Serum interleukin-15 is elevated in systemic lupus erythematosus. Rheumatology (Oxford) (2001) 1.03
Expression of IL-15 in inflammatory pulmonary diseases. J Allergy Clin Immunol (2001) 1.03
Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA. J Immunol (1998) 1.02
IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy. Neurosci Lett (2007) 1.02
Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms. Eur J Immunol (1999) 0.97
Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice. Exp Neurol (2010) 0.97
Therapeutic targets for rheumatoid arthritis: Progress and promises. Autoimmunity (2014) 0.97
Stable expression clones and auto-induction for protein production in E. coli. Methods Mol Biol (2014) 0.96
IL-15 is elevated in serum patients with type 1 diabetes mellitus. Diabetes Res Clin Pract (2005) 0.93
Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release. Glia (2010) 0.91
Interleukin-15 activates proinflammatory and antimicrobial functions in polymorphonuclear cells. Infect Immun (1998) 0.91
A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing. FASEB J (2005) 0.91
Molecular pathways: interleukin-15 signaling in health and in cancer. Clin Cancer Res (2014) 0.90
IL-15 is elevated in sera of patients with relapsing-remitting multiple sclerosis. Folia Neuropathol (2002) 0.89
Identification and characterization of two alternative splice variants of human interleukin-2. J Biol Chem (1996) 0.87
Alternative splice variants of cytokines: making a list. Life Sci (1997) 0.84
Molecular model of an alternative splice variant of human IL-4, IL-4 delta 2, a naturally occurring inhibitor of IL-4-stimulated T cell proliferation. Immunol Lett (1997) 0.83
New strategies to control inflammatory synovitis: interleukin 15 and beyond. Ann Rheum Dis (2003) 0.83
The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis. Immunobiology (2012) 0.82
Novel IL-15 isoforms generated by alternative splicing are expressed in the intestinal epithelium. Genes Immun (2006) 0.82
Interleukin and interleukin receptor diversity: role of alternative splicing. Int Rev Immunol (2010) 0.82
T-cell receptors for cytokines: targets for immunotherapy of leukemia/lymphoma. Ann Oncol (2000) 0.81
IL-15-dependent CD8+ CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL-17 production by CD4+ T cells. Eur J Immunol (2014) 0.81
Preparation of core-shell PAN nanofibers encapsulated α-tocopherol acetate and ascorbic acid 2-phosphate for photoprotection. Colloids Surf B Biointerfaces (2010) 0.80
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease. Nat Commun (2016) 0.78
Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells. Sci Rep (2015) 0.77
IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. Mol Immunol (2015) 0.76
Molecular models of two competitive inhibitors, IL-2delta2 and IL-2delta3, generated by alternative splicing of human interleukin-2. Immunol Lett (1998) 0.76