Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15.

PubWeight™: 1.71‹?› | Rank: Top 3%

🔗 View Article (PMID 10233906)

Published in Blood on May 15, 1999

Authors

T Musso1, L Calosso, M Zucca, M Millesimo, D Ravarino, M Giovarelli, F Malavasi, A N Ponzi, R Paus, S Bulfone-Paus

Author Affiliations

1: Department of Public Health and Microbiology, Postgraduate School of Clinical Pathology, University of Turin, Turin, Italy. musso@molinette.unito.it

Articles citing this

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med (2011) 3.27

Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood (2005) 2.81

Programming of human monocytes by the uteroplacental environment. Reprod Sci (2008) 1.69

Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett (2009) 1.64

Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut (2005) 1.55

IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. J Exp Med (2010) 1.52

Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation. Blood (2008) 1.39

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model. J Clin Invest (2003) 1.37

Survival adjustment of mature dendritic cells by IL-15. Proc Natl Acad Sci U S A (2005) 1.37

Functions of γC cytokines in immune homeostasis: current and potential clinical applications. Clin Immunol (2009) 1.22

Natural killer cell engineering for cellular therapy of cancer. Tissue Antigens (2011) 1.18

Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells. Arthritis Res (2000) 1.15

How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol Cell Biol (2008) 1.11

Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy. J Biomed Biotechnol (2011) 1.09

Regulating the immune system via IL-15 transpresentation. Cytokine (2012) 1.08

Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion. Arthritis Res (2000) 1.06

CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol (2013) 1.05

The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. PLoS Pathog (2011) 1.05

Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species. Clin Vaccine Immunol (2008) 1.02

Expansion and activation of natural killer cells for cancer immunotherapy. Korean J Lab Med (2009) 1.02

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes Infect (2011) 1.01

Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics. Genome Biol (2007) 0.96

CD40-CD40 ligand (CD154) engagement is required but may not be sufficient for human T helper 1 cell induction of interleukin-2- or interleukin-15-driven, contact-dependent, interleukin-1beta production by monocytes. Immunology (2000) 0.95

Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA. J Immunol (2013) 0.95

B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. J Immunol (2011) 0.94

Studies on the production of IL-15 in HIV-infected/AIDS patients. J Clin Immunol (2003) 0.89

Interleukin-15 and interferon-gamma participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production. Arthritis Res Ther (2006) 0.89

Interleukin-15 enhances innate and adaptive immune responses to blood-stage malaria infection in mice. Infect Immun (2005) 0.89

Gamma interferon suppresses erythropoiesis via interleukin-15. Infect Immun (2007) 0.88

Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice. Clin Vaccine Immunol (2006) 0.85

Interleukin-15 enhances proliferation and chemokine secretion of human follicular dendritic cells. Immunology (2010) 0.84

Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner. PLoS One (2015) 0.83

Production and distribution of interleukin 15 and its receptors (IL-15Ralpha and IL-R2beta) in the implant interface tissues obtained during revision of failed total joint replacement. Int J Exp Pathol (2001) 0.82

Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types. J Leukoc Biol (2010) 0.82

Efficient delivery of lentiviral vectors into resting human CD4 T cells. Gene Ther (2014) 0.80

Tumor Therapy Applying Membrane-bound Form of Cytokines. Immune Netw (2009) 0.80

Juxtacrine function of interleukin-15/interleukin-15 receptor system in tumour derived human B-cell lines. Clin Exp Immunol (2006) 0.80

Expression of interleukin-15 and interleukin-15Rα in monocytes of HIV type 1-infected patients with different courses of disease progression. AIDS Res Hum Retroviruses (2011) 0.79

Subcellular expression pattern and role of IL-15 in pneumococci induced lung epithelial apoptosis. Histochem Cell Biol (2008) 0.79

Rituximab-induced interleukin-15 reduction associated with clinical improvement in rheumatoid arthritis. Immunology (2014) 0.78

Massive interleukin-12-induced interferon-gamma production by interleukin-15-stimulated lamina propria lymphocytes followed by down-regulation of the interleukin-12 receptor. Immunology (2008) 0.78

Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS. J Neuroimmunol (2008) 0.78

Heterogeneous interleukin-15 inducibilities in murine B16 melanoma and RM-1 prostate carcinoma by interferon-alpha treatment. J Interferon Cytokine Res (2009) 0.77

Proinflammatory soluble interleukin-15 receptor alpha is increased in rheumatoid arthritis. Arthritis (2012) 0.76

Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling. Clin Immunol (2014) 0.76

An activation-induced IL-15 isoform is a natural antagonist for IL-15 function. Sci Rep (2016) 0.76

TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells. J Immunol (2015) 0.76

Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling. Int J Clin Exp Pathol (2011) 0.75

Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol (2016) 0.75

T cell interleukin-15 surface expression in chimpanzees infected with human immunodeficiency virus. Cell Immunol (2014) 0.75

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity. PLoS Pathog (2016) 0.75

Articles by these authors

A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol (2001) 6.12

Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58

Controls of hair follicle cycling. Physiol Rev (2001) 5.49

Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99

Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev (2000) 2.98

DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice. J Immunol (2000) 2.65

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J (2000) 2.41

The release of platelet-activating factor from human endothelial cells in culture. J Immunol (1983) 2.41

Interleukin-15 protects from lethal apoptosis in vivo. Nat Med (1997) 2.22

Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J (2000) 2.09

Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J Exp Med (1998) 2.08

Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J (2001) 1.95

Melanogenesis is coupled to murine anagen: toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invest Dermatol (1993) 1.88

Analysis of apoptosis during hair follicle regression (catagen) Am J Pathol (1997) 1.82

Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast. J Pathol (2001) 1.78

Graying: gerontobiology of the hair follicle pigmentary unit. Exp Gerontol (2001) 1.75

What are melanocytes really doing all day long...? Exp Dermatol (2009) 1.65

Retracted Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain. FASEB J (1999) 1.60

Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member. J Immunol (1998) 1.59

Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J Lab Clin Med (1993) 1.58

Melanocytes as "sensory" and regulatory cells in the epidermis. J Theor Biol (1993) 1.55

Production and characterisation of a monoclonal antibody to a cell-surface, glucomannoprotein constituent of Candida albicans and other pathogenic Candida species. J Med Microbiol (1988) 1.54

Human CD38: a glycoprotein in search of a function. Immunol Today (1994) 1.53

Antibody-induced redistribution of Heymann antigen on the surface of cultured glomerular visceral epithelial cells: possible role in the pathogenesis of Heymann glomerulonephritis. J Immunol (1985) 1.52

A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes. Biochem Biophys Res Commun (1993) 1.52

The human myeloma cell line LP-1: a versatile model in which to study early plasma-cell differentiation and c-myc activation. Blood (1989) 1.51

Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo. FASEB J (2000) 1.48

Evidence of an immunologic mechanism behind the therapeutical effects of arsenic trioxide (As(2)O(3)) on myeloma cells. Leuk Res (2001) 1.46

Immune interferon activates cells more slowly than does virus-induced interferon. Proc Soc Exp Biol Med (1978) 1.44

Interaction between endothelium and CD4+CD45RA+ lymphocytes. Role of the human CD38 molecule. J Immunol (1994) 1.44

The human hair follicle immune system: cellular composition and immune privilege. Br J Dermatol (2000) 1.42

Human CD38: a (r)evolutionary story of enzymes and receptors. Leuk Res (2001) 1.41

Failure of topical estrogen receptor agonists and antagonists to alter murine hair follicle cycling. J Invest Dermatol (1998) 1.40

Impaired NK1.1+ T cells do not prevent the development of an IgE-dependent allergic phenotype. Clin Exp Allergy (1998) 1.39

The 'melanocyte-keratin' mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6 in situ. Br J Dermatol (2009) 1.39

Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol (2008) 1.39

The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis. Dev Biol (1999) 1.38

The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation. Am J Pathol (1999) 1.38

Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived Neurotrophic functions. Am J Pathol (1999) 1.37

Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur J Immunol (1998) 1.37

CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis. Blood (1996) 1.35

Alkaline phosphatase activity and localization during the murine hair cycle. Br J Dermatol (1994) 1.34

Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans. Exp Dermatol (1998) 1.33

Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo. Science (1985) 1.30

Role of CD38 in HIV-1 infection: an epiphenomenon of T-cell activation or an active player in virus/host interactions? AIDS (2000) 1.30

Identification of malignant plasma cell precursors in the bone marrow of multiple myeloma. J Clin Invest (1985) 1.30

Antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines compared with exogenous IL-12. J Natl Cancer Inst (1997) 1.30

Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? J Immunol (2000) 1.29

Inhibition of melanogenesis as an adjuvant strategy in the treatment of melanotic melanomas: selective review and hypothesis. Anticancer Res (1999) 1.29

Human CD38, a cell-surface protein with multiple functions. FASEB J (1996) 1.29

Active hair growth (anagen) is associated with angiogenesis. J Invest Dermatol (2000) 1.29

Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation. J Immunol (1990) 1.28

Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle. J Invest Dermatol (1994) 1.27

Involvement of hepatocyte growth factor/scatter factor and met receptor signaling in hair follicle morphogenesis and cycling. FASEB J (2000) 1.26

Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair. FASEB J (2009) 1.25

Enzymatic induction of interferon production by galactose oxidase treatment of human lymphoid cells. Infect Immun (1979) 1.25

Management of alopecia areata. BMJ (2010) 1.25

Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J Immunol (1997) 1.24

Differential expression and activity of melanogenesis-related proteins during induced hair growth in mice. J Invest Dermatol (1991) 1.24

E- and P-cadherin expression during murine hair follicle morphogenesis and cycling. Exp Dermatol (1999) 1.22

Characterization of functional vanilloid receptors expressed by mast cells. Blood (1998) 1.21

Retracted The IL-15R alpha chain signals through association with Syk in human B cells. J Immunol (2001) 1.20

Proliferation of human peripheral blood mononuclear cells induced by Candida albicans and its cell wall fractions. J Med Microbiol (1986) 1.20

Hair cycle-dependent plasticity of skin and hair follicle innervation in normal murine skin. J Comp Neurol (1997) 1.20

Anti-HIV effects of chloroquine: mechanisms of inhibition and spectrum of activity. AIDS (2001) 1.19

Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?". Ann N Y Acad Sci (1999) 1.18

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants. Cancer Res (1994) 1.18

Hair follicle expression of 1,25-dihydroxyvitamin D3 receptors during the murine hair cycle. Br J Dermatol (1994) 1.18

Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. Am J Pathol (1997) 1.17

Indications for a 'brain-hair follicle axis (BHA)': inhibition of keratinocyte proliferation and up-regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P. FASEB J (2001) 1.17

Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD. Blood (2000) 1.16

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene. J Immunol (1992) 1.15

Inhibition of tumor growth and enhancement of metastasis after transfection of the gamma-interferon gene. Int J Cancer (1993) 1.15

What causes alopecia areata? Exp Dermatol (2013) 1.14

IFN-alpha 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-gamma-producing TS/A cells. J Immunol (1994) 1.14

Decreased interferon response by lymphocytes from children with chronic hepatitis. J Infect Dis (1975) 1.13

Immune and virus-induced interferons may activate cells by different derepressional mechanisms. Nature (1980) 1.12

Lymphokine-activated tumor inhibition in vivo. I. The local administration of interleukin 2 triggers nonreactive lymphocytes from tumor-bearing mice to inhibit tumor growth. J Immunol (1985) 1.11

PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis. Cell Death Differ (2011) 1.11

Isoform-specific associations of CD45 with accessory molecules in human T lymphocytes. Eur J Immunol (1992) 1.09

Interleukin 2 activated tumor inhibition in vivo depends on the systemic involvement of host immunoreactivity. J Immunol (1987) 1.07

The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells. Leukemia (2012) 1.07

Towards defining the pathogenesis of the hairless phenotype. J Invest Dermatol (1998) 1.06

CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia (2010) 1.06

CD38 functions are regulated through an internalization step. J Immunol (1998) 1.06

Secretion of IFN-gamma, IL-6, granulocyte-macrophage colony-stimulating factor and IL-10 cytokines after activation of human purified T lymphocytes upon CD38 ligation. Cell Immunol (1996) 1.05

Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia (1992) 1.05

Distinct patterns of NCAM expression are associated with defined stages of murine hair follicle morphogenesis and regression. J Histochem Cytochem (1998) 1.05

CD38 signal transduction in human B cell precursors. Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and phosphatidylinositol 3-kinase. J Immunol (1996) 1.05

On the potential role of proopiomelanocortin in skin physiology and pathology. Mol Cell Endocrinol (1993) 1.04

CD38 molecule: structural and biochemical analysis on human T lymphocytes, thymocytes, and plasma cells. J Immunol (1990) 1.04

Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes. Blood (1997) 1.04

CD38/CD31, a receptor/ligand system ruling adhesion and signaling in human leukocytes. Chem Immunol (2000) 1.04

Keratin 17 gene expression during the murine hair cycle. J Invest Dermatol (1997) 1.03

Evidence that the bulge region is a site of relative immune privilege in human hair follicles. Br J Dermatol (2008) 1.03

Murine monoclonal antibodies as probes for the phenotypical, functional, and molecular analysis of a discrete peripheral blood lymphocyte population exerting natural killer activity in vitro. Hum Immunol (1985) 1.03

Characterization of a murine monoclonal antibody specific for human early lymphohemopoietic cells. Hum Immunol (1984) 1.03