Published in Sci Rep on May 13, 2016
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc (2007) 12.39
TGF-beta signaling and the fibrotic response. FASEB J (2004) 9.81
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol (1993) 8.36
Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med (2012) 6.15
Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2007) 5.92
Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell (1998) 5.88
Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest (1997) 5.77
Idiopathic pulmonary fibrosis. N Engl J Med (2001) 5.49
Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta. J Exp Med (1987) 4.35
Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell (2001) 4.25
CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol (2005) 4.02
Fibrosis--a common pathway to organ injury and failure. N Engl J Med (2015) 3.94
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell (2002) 3.80
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell (2010) 2.86
The role of CCL12 in the recruitment of fibrocytes and lung fibrosis. Am J Respir Cell Mol Biol (2006) 2.68
Bleomycins: towards better therapeutics. Nat Rev Cancer (2005) 2.52
The role of CXC chemokines in pulmonary fibrosis. J Clin Invest (2007) 2.41
Time course of bleomycin-induced lung fibrosis. Int J Exp Pathol (2002) 1.98
P-Rex1 regulates neutrophil function. Curr Biol (2005) 1.97
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene (2009) 1.76
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. Am J Physiol Lung Cell Mol Physiol (2000) 1.75
The impact of TGF-β on lung fibrosis: from targeting to biomarkers. Proc Am Thorac Soc (2012) 1.74
P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol (2005) 1.70
P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer. Oncogene (2010) 1.66
HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta. Cancer Res (2006) 1.52
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits. J Biol Chem (2004) 1.49
p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci (2006) 1.28
A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2002) 1.20
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. FASEB J (2013) 1.01
P-Rex1 - a multidomain protein that regulates neurite differentiation. J Cell Sci (2008) 1.00
Transforming growth factor-beta1 induces collagen synthesis and accumulation via p38 mitogen-activated protein kinase (MAPK) pathway in cultured L(6)E(9) myoblasts. FEBS Lett (2002) 0.97
Regulation and function of P-Rex family Rac-GEFs. Small GTPases (2015) 0.92
A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability. Circ Res (2012) 0.91
Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice. Toxicol Appl Pharmacol (1989) 0.91
P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood (2014) 0.81
Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. Cell Signal (2010) 0.80